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  1. Chronic Granulomatous Disease (CGD), a disorder of the NADPH oxidase system, results in phagocyte functional defects and subsequent infections with bacterial and fungal pathogens (such as Aspergillus species and

    Authors: Casey E Watkins, John Litchfield, Eunkyung Song, Gayatri B Jaishankar, Niva Misra, Nikhil Holla, Michelle Duffourc and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2011 9:13

    Content type: Review

    Published on:

  2. To examine whether whole genome expression profiling could reveal changes in mRNA expression of peripheral blood mononuclear cells (PBMC) from allergic patients undergoing rush immunotherapy (RIT) that might b...

    Authors: Laurie S Davis, Sumit Bhutani, Sherry Ridz Barnett and David A Khan

    Citation: Clinical and Molecular Allergy 2011 9:12

    Content type: Research

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  3. Omalizumab, a humanized monoclonal anti-IgE antibody has the potential to alter allergen processing. Recently, it has been postulated the assessment of PHA-stimulated adenosine triphosphate (ATP) activity as m...

    Authors: Inmaculada Sánchez-Machín, Javier Iglesias-Souto, Andrés Franco, Yvelise Barrios, Ruperto Gonzalez and Víctor Matheu

    Citation: Clinical and Molecular Allergy 2011 9:11

    Content type: Commentary

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  4. Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formatio...

    Authors: EunKyung Song, Gayatri Bala Jaishankar, Hana Saleh, Warit Jithpratuck, Ryan Sahni and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2011 9:10

    Content type: Review

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  5. Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthr...

    Authors: Warit Jithpratuck, Yasmin Elshenawy, Hana Saleh, George Youngberg, David S Chi and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2011 9:9

    Content type: Review

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  6. Objective markers of early airway inflammation in infants are not established but are of great interest in a scientific setting. Exhaled nitric oxide (FeNO) and urinary eosinophilic protein X (uEPX) are a two ...

    Authors: Fredrik Carlstedt, Dagmara Lazowska, Carl-Gustaf Bornehag, Anna-Carin Olin and Mikael Hasselgren

    Citation: Clinical and Molecular Allergy 2011 9:8

    Content type: Research

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  7. Anti-IgE therapy inhibits mast cell and basophil activation, blocks IgE binding to both FcεRI and CD23 and down regulates FcεRI expression by antigen (Ag) presenting cells (APCs). In addition to its classical ...

    Authors: Barbara Foster, Shabnam Foroughi, Yuzhi Yin and Calman Prussin

    Citation: Clinical and Molecular Allergy 2011 9:7

    Content type: Research

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  8. The field of primary immunodeficiencies (PIDs) is one of several in the area of clinical immunology that has not been static, but rather has shown exponential growth due to enhanced physician, scientist and pa...

    Authors: Roshini S Abraham

    Citation: Clinical and Molecular Allergy 2011 9:6

    Content type: Review

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  9. In 2006, the Norwegian Medicines Agency mandated a switch from desloratadine, ebastine, or fexofenadine to cetirizine or loratadine in patients with allergic rhinitis (AR) or chronic urticaria (CU). In an onli...

    Authors: Fredrik Thorn, Halvor Celius, Tone Ødegård, Randeep Mandla and Erik Hexeberg

    Citation: Clinical and Molecular Allergy 2011 9:5

    Content type: Research

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  10. Atopic dermatitis is a chronic, allergic inflammatory skin disease that is accompanied by markedly increased levels of inflammatory cells, including eosinophils, mast cells, and T cells. Arctium lappa L. is a tra...

    Authors: Eun-Hwa Sohn, Seon-A Jang, Haemi Joo, Sulkyoung Park, Se-Chan Kang, Chul-Hoon Lee and Sun-Young Kim

    Citation: Clinical and Molecular Allergy 2011 9:4

    Content type: Research

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  11. Patients with allergic rhinitis and allergic asthma demonstrate comparable local and systemic eosinophil inflammation, and yet they present with different clinical pictures. Less is even known about the contri...

    Authors: Mary Kämpe, Ingrid Stolt, Maria Lampinen, Christer Janson, Gunnemar Stålenheim and Marie Carlson

    Citation: Clinical and Molecular Allergy 2011 9:3

    Content type: Research

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  12. Chronic idiopathic urticaria is a condition that is often controllable with antihistamine therapy. However, some patients have disease burden that is difficult to manage, non-responsive to antihistamines and o...

    Authors: Michael C Saavedra and Sanjiv Sur

    Citation: Clinical and Molecular Allergy 2011 9:2

    Content type: Case Report

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  13. Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in ...

    Authors: Supinda Bunyavanich, Erik Melen, Jemma B Wilk, Mark Granada, Manuel E Soto-Quiros, Lydiana Avila, Jessica Lasky-Su, Gary M Hunninghake, Magnus Wickman, Göran Pershagen, George T O'Connor, Scott T Weiss and Juan C Celedόn

    Citation: Clinical and Molecular Allergy 2011 9:1

    Content type: Research

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  14. Skin prick testing is widely used to predict the presence of allergen-specific IgE. In eosinophilic esophagitis patients, who frequently exhibit polysensitization and broad reactivity upon skin prick testing, ...

    Authors: Toral A Kamdar, Anne M Ditto and Paul J Bryce

    Citation: Clinical and Molecular Allergy 2010 8:16

    Content type: Case Report

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  15. A. fumigatus has been associated with a wide spectrum of allergic disorders such as ABPA or SAFS. It is poorly understood what allergens in particular are being expressed during fungal invasion and which are resp...

    Authors: Marcin G Fraczek, Rifat Rashid, Marian Denson, David W Denning and Paul Bowyer

    Citation: Clinical and Molecular Allergy 2010 8:15

    Content type: Research

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  16. Histamine-metabolizing enzymes (N-methyltransferase and amiloride binding protein 1) are responsible for histamine degradation, a biogenic amine involved in allergic inflammation. Genetic variants of HNMT and ABP...

    Authors: Aleksandra Szczepankiewicz, Anna Bręborowicz, Paulina Sobkowiak and Anna Popiel

    Citation: Clinical and Molecular Allergy 2010 8:14

    Content type: Research

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  17. Flavonoids, a large group of polyphenolic metabolites derived from plants have received a great deal of attention over the last several decades for their properties in inflammation and allergy. Quercetin, the ...

    Authors: Salvatore Chirumbolo, Marta Marzotto, Anita Conforti, Antonio Vella, Riccardo Ortolani and Paolo Bellavite

    Citation: Clinical and Molecular Allergy 2010 8:13

    Content type: Research

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  18. Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN...

    Authors: Haorile Chagan-Yasutan, Beata Shiratori, Umme Ruman Siddiqi, Hiroki Saitoh, Yugo Ashino, Tomohiro Arikawa, Mitsuomi Hirashima and Toshio Hattori

    Citation: Clinical and Molecular Allergy 2010 8:12

    Content type: Case Report

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  19. Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However, the association of allergen-induced cord blood mononuclear cel...

    Authors: Carolyn Chang, Kevin Gauvey-Kern, Alina Johnson, Elizabeth A Kelvin, Ginger L Chew, Frederica Perera and Rachel L Miller

    Citation: Clinical and Molecular Allergy 2010 8:11

    Content type: Research

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  20. Eosinophils are involved in various inflammatory processes including allergic inflammation during which angiogenesis has been documented. Angiogenesis is most likely connected to the hypoxia which characterize...

    Authors: Alon H Nissim Ben Efraim, Ron Eliashar and Francesca Levi-Schaffer

    Citation: Clinical and Molecular Allergy 2010 8:10

    Content type: Research

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  21. The mechanism(s) responsible for the reduced risk of allergic disease in breastfed infants are not fully understood. Using an established murine model of asthma, we demonstrated previously that resistance to a...

    Authors: Adam P Matson, Roger S Thrall, Ektor Rafti, Elizabeth G Lingenheld and Lynn Puddington

    Citation: Clinical and Molecular Allergy 2010 8:9

    Content type: Research

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  22. Atopic dermatitis (AD) is often the prelude to allergic diseases. The aim of this study was 1) to evaluate if an integrated management regime could bring about a change in the evolution of the disease in compa...

    Authors: Giampaolo Ricci, Annalisa Patrizi, Arianna Giannetti, Arianna Dondi, Barbara Bendandi and Massimo Masi

    Citation: Clinical and Molecular Allergy 2010 8:8

    Content type: Research

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  23. Hymenoptera venoms are known to cause life-threatening IgE-mediated anaphylactic reactions in allergic individuals. Proper diagnosis of hymenoptera venom allergy using venom extracts is severely affected by mo...

    Authors: Henning Seismann, Simon Blank, Liliana Cifuentes, Ingke Braren, Reinhard Bredehorst, Thomas Grunwald, Markus Ollert and Edzard Spillner

    Citation: Clinical and Molecular Allergy 2010 8:7

    Content type: Research

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  24. Mannose-binding lectin (MBL) and the Mannose-binding lectin-associated serine proteases (MASPs) are an essential aspect of innate immune responses that probably play an important but understudied role in cutan...

    Authors: Christopher Miller, Sara Wilgenbusch, Mini Michael, David S Chi, George Youngberg and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2010 8:6

    Content type: Review

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  25. Asthma afflicts 6% to 8% of the United States population, and severe asthma represents approximately 10% of asthmatic patients. Several epidemiologic studies in the United States and Europe have linked Alternaria

    Authors: Alan P Knutsen, Hari M Vijay, Barbara Kariuki, Luis A Santiago, Ralph Graff, Jonathan D Wofford and Maulik R Shah

    Citation: Clinical and Molecular Allergy 2010 8:5

    Content type: Research

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  26. Some studies reported the possible induction of food allergy, caused by neo-sensitization to cross-reacting allergens, during immunotherapy with aeroallergens, while other studies ruled out such possibility.

    Authors: Renato E Rossi, Giorgio Monasterolo, Cristoforo Incorvaia, Philippe Moingeon, Franco Frati, Giovanni Passalacqua, Lucilla Rossi and Giorgio W Canonica

    Citation: Clinical and Molecular Allergy 2010 8:4

    Content type: Research

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  27. Altered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecul...

    Authors: Mariah B Pate, John Kelly Smith, David S Chi and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2010 8:3

    Content type: Review

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  28. Subcutaneous Immunotherapy (SCIT) modifies the allergic response and relieves allergic symptoms. SCIT is the only and a very effective treatment for insect venom allergy. We hypothesized that basophil sensitiv...

    Authors: Susan Mikkelsen, Bo Martin Bibby, Mette Konow Bøgebjerg Dolberg, Ronald Dahl and Hans Jürgen Hoffmann

    Citation: Clinical and Molecular Allergy 2010 8:2

    Content type: Research

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  29. Rhinitis is characterized by rhinorrhea, sneezing, nasal congestion, nasal itch and/or postnasal drip. Often the first step in arriving at a diagnosis is to exclude or diagnose sensitivity to inhalant allergen...

    Authors: Cyrus H Nozad, L Madison Michael, D Betty Lew and Christie F Michael

    Citation: Clinical and Molecular Allergy 2010 8:1

    Content type: Review

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  30. Sensitization to Thyreophagus entomophagus, a storage mite, is uncommon and might produce occupational respiratory disorders in farmers. We present the first case of a child suffering anaphylaxis produced by inge...

    Authors: Javier Iglesias-Souto, Inmaculada Sánchez-Machín, Víctor Iraola, Paloma Poza, Ruperto González and Víctor Matheu

    Citation: Clinical and Molecular Allergy 2009 7:10

    Content type: Case Report

    Published on:

  31. The use of biotechnological techniques to introduce novel proteins into food crops (transgenic or GM crops) has motivated investigation into the properties of proteins that favor their potential to elicit alle...

    Authors: Rod A Herman, Ping Song and Arvind ThirumalaiswamySekhar

    Citation: Clinical and Molecular Allergy 2009 7:9

    Content type: Research

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  32. In the United States, asthma prevalence is particularly high among urban children. Although the underlying immune mechanism contributing to asthma has not been identified, having impaired T regulatory (Treg) c...

    Authors: Ngoc P Ly, Begona Ruiz-Perez, Rachel M McLoughlin, Cynthia M Visness, Paul K Wallace, William W Cruikshank, Arthur O Tzianabos, George T O'Connor, Diane R Gold and James E Gern

    Citation: Clinical and Molecular Allergy 2009 7:8

    Content type: Research

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  33. Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized s...

    Authors: Amrendra Kumar and Balaram Ghosh

    Citation: Clinical and Molecular Allergy 2009 7:7

    Content type: Review

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  36. Though not widely recognized, food hypersensitivity by inhalation can cause major morbidity in affected individuals. The exposure is usually more obvious and often substantial in occupational environments but ...

    Authors: Daniel A Ramirez Jr and Sami L Bahna

    Citation: Clinical and Molecular Allergy 2009 7:4

    Content type: Review

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  37. Bermuda grass (Cynodon dactylon; subfamily Chloridoideae) is an important source of seasonal aeroallergens in warm tropical and sub-tropical areas worldwide. Improved approaches to diagnosis and therapy of allerg...

    Authors: Ruby Tiwari, Prem L Bhalla and Mohan B Singh

    Citation: Clinical and Molecular Allergy 2009 7:3

    Content type: Research

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  38. Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition, recent evidence strongly suggests that viral infections may also have a causal role in the development ...

    Authors: Matthew M Huckabee and R Stokes Peebles Jr

    Citation: Clinical and Molecular Allergy 2009 7:2

    Content type: Review

    Published on:

  39. Food allergies affect an estimated 3 to 4% of adults and up to 8% of children in developed western countries. Results from in vitro simulated gastric digestion studies with purified proteins are routinely used to...

    Authors: Santiago Schnell and Rod A Herman

    Citation: Clinical and Molecular Allergy 2009 7:1

    Content type: Review

    Published on:

  40. Hypersensitivity to human seminal fluid is rare but can be life threatening. We report a case of IgE-mediated anaphylaxis to seminal plasma that was diagnosed by skin prick tests and successfully treated by lo...

    Authors: Jaechun Lee, Sohyung Kim, Miok Kim, Young-Bae Chung, Jung-Sik Huh, Chul Min Park, Keun Hwa Lee and Jeong Hong Kim

    Citation: Clinical and Molecular Allergy 2008 6:13

    Content type: Case Report

    Published on:

  41. Basophils are circulating cells involved in hypersensitivity reactions and allergy but many aspects of their activation, including the sensitivity to external triggering factors and the molecular aspects of ce...

    Authors: Salvatore Chirumbolo, Antonio Vella, Riccardo Ortolani, Marzia De Gironcoli, Pietro Solero, Giuseppe Tridente and Paolo Bellavite

    Citation: Clinical and Molecular Allergy 2008 6:12

    Content type: Research

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  42. A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results.

    Authors: Erick Forno, Andrew B Onderdonk, John McCracken, Augusto A Litonjua, Daniel Laskey, Mary L Delaney, Andrea M DuBois, Diane R Gold, Louise M Ryan, Scott T Weiss and Juan C Celedón

    Citation: Clinical and Molecular Allergy 2008 6:11

    Content type: Research

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  43. Mucosal-based immunotherapy has been already used as an alternative form of allergen delivery. In asthma, the poor success rate of immune modulation could be a consequence of inadequate immune modulation in th...

    Authors: Tahereh Mousavi, Nader Tajik, Maziar Moradi and Masoomeh Fallah Radjabzadeh

    Citation: Clinical and Molecular Allergy 2008 6:10

    Content type: Research

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  45. In the 1920's, Hoover described a sign that could be considered a marker of severe airway obstruction. While readily recognizable at the bedside, it may easily be missed on a cursory physical examination. Hoov...

    Authors: Chambless R Johnston III, Narayanaswamy Krishnaswamy and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2008 6:8

    Content type: Review

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  46. During production of sugar beet (Beta vulgaris) seeds in greenhouses, workers frequently develop allergic symptoms. The aim of this study was to identify and characterize possible allergens in sugar beet pollen.

    Authors: Susanne Luoto, Wietske Lambert, Anna Blomqvist and Cecilia Emanuelsson

    Citation: Clinical and Molecular Allergy 2008 6:7

    Content type: Research

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  47. IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases.

    Authors: Michael Pistiner, Gary M Hunninghake, Manuel E Soto-Quiros, Lydiana Avila, Amy Murphy, Jessica Lasky-Su, Brooke Schuemann, Barbara J Klanderman, Benjamin A Raby and Juan C Celedón

    Citation: Clinical and Molecular Allergy 2008 6:6

    Content type: Research

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  49. Atopic diseases and asthma are increasing at a remarkable rate on a global scale. It is now well recognized that asthma is a chronic inflammatory disease of the airways. The inflammatory process in many patien...

    Authors: Christopher WT Miller, Narayanaswamy Krishnaswamy, Chambless Johnston and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2008 6:4

    Content type: Review

    Published on:


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