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  1. Content type: Case Report

    Hypersensitivity to human seminal fluid is rare but can be life threatening. We report a case of IgE-mediated anaphylaxis to seminal plasma that was diagnosed by skin prick tests and successfully treated by lo...

    Authors: Jaechun Lee, Sohyung Kim, Miok Kim, Young-Bae Chung, Jung-Sik Huh, Chul Min Park, Keun Hwa Lee and Jeong Hong Kim

    Citation: Clinical and Molecular Allergy 2008 6:13

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  2. Content type: Research

    Basophils are circulating cells involved in hypersensitivity reactions and allergy but many aspects of their activation, including the sensitivity to external triggering factors and the molecular aspects of ce...

    Authors: Salvatore Chirumbolo, Antonio Vella, Riccardo Ortolani, Marzia De Gironcoli, Pietro Solero, Giuseppe Tridente and Paolo Bellavite

    Citation: Clinical and Molecular Allergy 2008 6:12

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  3. Content type: Research

    A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results.

    Authors: Erick Forno, Andrew B Onderdonk, John McCracken, Augusto A Litonjua, Daniel Laskey, Mary L Delaney, Andrea M DuBois, Diane R Gold, Louise M Ryan, Scott T Weiss and Juan C Celedón

    Citation: Clinical and Molecular Allergy 2008 6:11

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  4. Content type: Research

    Mucosal-based immunotherapy has been already used as an alternative form of allergen delivery. In asthma, the poor success rate of immune modulation could be a consequence of inadequate immune modulation in th...

    Authors: Tahereh Mousavi, Nader Tajik, Maziar Moradi and Masoomeh Fallah Radjabzadeh

    Citation: Clinical and Molecular Allergy 2008 6:10

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  6. Content type: Review

    In the 1920's, Hoover described a sign that could be considered a marker of severe airway obstruction. While readily recognizable at the bedside, it may easily be missed on a cursory physical examination. Hoov...

    Authors: Chambless R Johnston III, Narayanaswamy Krishnaswamy and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2008 6:8

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  7. Content type: Research

    During production of sugar beet (Beta vulgaris) seeds in greenhouses, workers frequently develop allergic symptoms. The aim of this study was to identify and characterize possible allergens in sugar beet pollen.

    Authors: Susanne Luoto, Wietske Lambert, Anna Blomqvist and Cecilia Emanuelsson

    Citation: Clinical and Molecular Allergy 2008 6:7

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  8. Content type: Research

    IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases.

    Authors: Michael Pistiner, Gary M Hunninghake, Manuel E Soto-Quiros, Lydiana Avila, Amy Murphy, Jessica Lasky-Su, Brooke Schuemann, Barbara J Klanderman, Benjamin A Raby and Juan C Celedón

    Citation: Clinical and Molecular Allergy 2008 6:6

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  10. Content type: Review

    Atopic diseases and asthma are increasing at a remarkable rate on a global scale. It is now well recognized that asthma is a chronic inflammatory disease of the airways. The inflammatory process in many patien...

    Authors: Christopher WT Miller, Narayanaswamy Krishnaswamy, Chambless Johnston and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2008 6:4

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  13. Content type: Research

    Commercial available skin prick test with fruits can be negative in sensitized or allergic patients due to a reduction in biological activity during the manufacturing process. Prick-prick tests with fresh food...

    Authors: Ángel Ferrer, Ángel J Huertas, Carlos H Larramendi, Jose L García-Abujeta, Joan Bartra, Jose R Lavín, Carmen Andreu, Juan A Pagán, María A López-Matas, Enrique Fernández-Caldas and Jerónimo Carnés

    Citation: Clinical and Molecular Allergy 2008 6:1

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  14. Content type: Research

    Human mast cells are multifunctional cells capable of a wide variety of inflammatory responses. Baicalein (BAI), isolated from the traditional Chinese herbal medicine Huangqin (Scutellaria baicalensis Georgi), ha...

    Authors: Chia-Jung Hsieh, Kenton Hall, Tuanzhu Ha, Chuanfu Li, Guha Krishnaswamy and David S Chi

    Citation: Clinical and Molecular Allergy 2007 5:5

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  17. Content type: Commentary

    The prediction of allergen cross-reactivity is currently largely based on linear sequence data, but will soon include 3D information on homology among surface exposed residues. To evaluate procedures for these...

    Authors: Rob C Aalberse

    Citation: Clinical and Molecular Allergy 2007 5:2

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  18. Content type: Research

    There has been a worldwide increase in allergy and asthma over the last few decades, particularly in industrially developed nations. This resulted in a renewed interest to understand the pathogenesis of allerg...

    Authors: Viswanath P Kurup, Christy S Barrios, Raghavan Raju, Bryon D Johnson, Michael B Levy and Jordan N Fink

    Citation: Clinical and Molecular Allergy 2007 5:1

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  19. Content type: Research

    The mechanisms for the association between birth by cesarean section and atopy and asthma are largely unknown.

    Authors: Ngoc P Ly, Begoña Ruiz-Pérez, Andrew B Onderdonk, Arthur O Tzianabos, Augusto A Litonjua, Catherine Liang, Daniel Laskey, Mary L Delaney, Andrea M DuBois, Hara Levy, Diane R Gold, Louise M Ryan, Scott T Weiss and Juan C Celedón

    Citation: Clinical and Molecular Allergy 2006 4:13

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  20. Content type: Research

    Entomopathogenic fungi such as Beauveria bassiana are considered promising biological control agents for a variety of arthropod pests. Beauveria species, however, have the potential to elicit allergenic reactions...

    Authors: Greg S Westwood, Shih-Wen Huang and Nemat O Keyhani

    Citation: Clinical and Molecular Allergy 2006 4:12

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  21. Content type: Research

    Aspergillus fumigatus, a widely distributed fungus, has been implicated in causing life threatening infections as well as severe asthma and allergic diseases in man. Allergic affliction like allergic bronchopulmo...

    Authors: Viswanath P Kurup, Alan P Knutsen, Richard B Moss and Naveen K Bansal

    Citation: Clinical and Molecular Allergy 2006 4:11

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  22. Content type: Research

    The potato is one of the most common types of genetically modified (GM) food. However, there are no published data evaluating the impact of genetic manipulations on the allergenicity of GM potatoes. To compare...

    Authors: Soo-Keol Lee, Young-Min Ye, Sung-Ho Yoon, Bou-Oung Lee, Seung-Hyun Kim and Hae-Sim Park

    Citation: Clinical and Molecular Allergy 2006 4:10

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  23. Content type: Research

    Atopy and allergic phenotypes are biologically characterized by an imbalanced T helper cell response skewed towards a type 2 (TH2) immune response associated with elevated serum immunoglobulin E (IgE) levels. ...

    Authors: M Imboden, A Nieters, AJ Bircher, M Brutsche, N Becker, M Wjst, U Ackermann-Liebrich, W Berger and NM Probst-Hensch

    Citation: Clinical and Molecular Allergy 2006 4:9

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  24. Content type: Review

    In spite of recent advances with experiments on animal models, strongyloidiasis, an infection caused by the nematode parasite Strongyloides stercoralis, has still been an elusive disease. Though endemic in some d...

    Authors: Raja S Vadlamudi, David S Chi and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2006 4:8

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  26. Content type: Research

    Chemokine receptors have been suggested to be preferentially expressed on CD4+ T cells with CCR3 and CCR8 linked to the T helper (Th) 2 subset and CCR5 and CXCR3 to the Th1 subset, however this remains controv...

    Authors: Mille Holse, Kristian Assing and Lars K Poulsen

    Citation: Clinical and Molecular Allergy 2006 4:6

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  27. Content type: Research

    House dust mite allergens (HDM) cause bronchoconstriction in asthma patients and induce an inflammatory response in the lungs due to the release of cytokines, chemokines and additional mediators. The mechanism...

    Authors: Henk F Kauffman, Michael Tamm, J André B Timmerman and Peter Borger

    Citation: Clinical and Molecular Allergy 2006 4:5

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  28. Content type: Research

    Vaccination with naked DNA encoding antigen induces cellular and humoral immunity characterized by the activation of specific Th1 cells.

    Authors: Nacksung Kim, Soon Seog Kwon, Jaechun Lee, Sohyung Kim and Tai June Yoo

    Citation: Clinical and Molecular Allergy 2006 4:4

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  29. Content type: Research

    Interleukin 8 (IL8) belongs to the family of chemokines. It mediates the activation and migration of neutrophils from peripheral blood into tissue and hereby plays a pivotal role in the initiation of inflammat...

    Authors: Beena Puthothu, Marcus Krueger, Jessica Heinze, Johannes Forster and Andrea Heinzmann

    Citation: Clinical and Molecular Allergy 2006 4:2

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  30. Content type: Research

    Allergic bronchopulmonary aspergillosis occurs in 7–10% of cystic fibrosis (CF) and 1–2% of asthmatic patients. HLA-DR restriction and increased sensitivity to IL-4 stimulation have been proposed as risk facto...

    Authors: Alan P Knutsen, Barbara Kariuki, Judy D Consolino and Manoj R Warrier

    Citation: Clinical and Molecular Allergy 2006 4:3

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  31. Content type: Research

    Avoidance of allergens is still recommended as the first and best way to prevent allergic illnesses and their comorbid diseases. Despite a variety of attempts there has been very limited success in the area of...

    Authors: C Steven Smith, Scott A Smith, Thomas J Grier and David E Justus

    Citation: Clinical and Molecular Allergy 2006 4:1

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  32. Content type: Case Report

    A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick a...

    Authors: Victor Matheu, Eva Perez, Marta Hernández, Elisa Díaz, Ricardo Darias, Abel González, Jose C García, Inmaculada Sánchez, Laura Feliciano, Agueda Caballero and Fernando de la Torre

    Citation: Clinical and Molecular Allergy 2005 3:16

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  33. Content type: Research

    IL4/IL4RA pathway plays an important role in atopy and asthma. Different polymorphisms in IL4 and IL4RA genes have been described. Particularly, -33C>TIL4 and 576Q>RIL4RA SNPs have been independently associated t...

    Authors: María Isidoro-García, Ignacio Dávila, Elena Laffond, Esther Moreno, Félix Lorente and Rogelio González-Sarmiento

    Citation: Clinical and Molecular Allergy 2005 3:15

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  34. Content type: Case Report

    Allergic sensitization and reactions to guinea pig (Cavia porcellus) have been well documented in laboratory animal handlers, primarily manifesting as rhinitis, conjunctivitis, and asthma. Severe allergic reactio...

    Authors: Michael C Zacharisen, Michael B Levy, Jeffrey L Shaw and Viswanath P Kurup

    Citation: Clinical and Molecular Allergy 2005 3:14

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  35. Content type: Research

    Profilins are highly cross-reactive allergens which bind IgE antibodies of almost 20% of plant-allergic patients. This study is aimed at investigating cross-reactivity of melon profilin with other plant profil...

    Authors: Mojtaba Sankian, Abdolreza Varasteh, Nazanin Pazouki and Mahmoud Mahmoudi

    Citation: Clinical and Molecular Allergy 2005 3:13

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  36. Content type: Research

    Previously we treated patients with insect sting allergy with venom immunotherapy (IT) using whole body insect extracts. From 1980 we changed to insect venoms. The purpose of this study was to analyse data fro...

    Authors: Rolf Haye and Liv Kari Døsen

    Citation: Clinical and Molecular Allergy 2005 3:12

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  37. Content type: Research

    In recent years, allergy to natural rubber latex has emerged as a major allergy among certain occupational groups and patients with underlying diseases. The sensitization and development of latex allergy has b...

    Authors: Viswanath P Kurup, Gordon L Sussman, Hoong Y Yeang, Nancy Elms, Heimo Breiteneder, Siti AM Arif, Kevin J Kelly, Naveen K Bansal and Jordan N Fink

    Citation: Clinical and Molecular Allergy 2005 3:11

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  38. Content type: Research

    The basophil activation test (BAT), in which translocation of markers to the surface of blood basophils is measured in response to allergen by flow cytometry, is a rapid assay that is gaining popularity. Two m...

    Authors: Hans Jürgen Hoffmann, Mette Bøgebjerg, Lars Peter Nielsen and Ronald Dahl

    Citation: Clinical and Molecular Allergy 2005 3:10

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  39. Content type: Review

    The diagnosis of immediate allergy is mainly based upon an evocative clinical history, positive skin tests (gold standard) and, if available, detection of specific IgE. In some complicated cases, functional in vi...

    Authors: Radhia Boumiza, Anne-Lise Debard and Guillaume Monneret

    Citation: Clinical and Molecular Allergy 2005 3:9

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  40. Content type: Case Report

    Animal-derived allergens include lipocalins which play an increasing role in occupational respiratory sensitizations. The prevention of sensitization in stock farming is often difficult due to intense exposure...

    Authors: Gintautas Korinth, Horst Christoph Broding, Wolfgang Uter and Hans Drexler

    Citation: Clinical and Molecular Allergy 2005 3:8

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  42. Content type: Research

    Airway smooth muscle cells play a key role in remodeling that contributes to airway hyperreactivity. Airway smooth muscle remodeling includes hypertrophy and hyperplasia. It has been previously shown that the ...

    Authors: Joseph T Belleau, Radha K Gandhi, Holly M McPherson and D Betty Lew

    Citation: Clinical and Molecular Allergy 2005 3:6

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  45. Content type: Research

    A circadian rhythm of symptoms has been reported in allergic rhinitis and some studies have shown the dosing time of antihistamines to be of importance for optimizing symptom relief in this disease. The object...

    Authors: Rolf Haye, Kjetil Høye, Olof Berg, Sissel Frønes and Tone Ødegård

    Citation: Clinical and Molecular Allergy 2005 3:3

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  46. Content type: Research

    Asthma and sickle cell disease are common conditions that both may result in pulmonary complications. We hypothesized that children with sickle cell disease with concomitant asthma have an increased incidence ...

    Authors: Mark E Nordness, John Lynn, Michael C Zacharisen, Paul J Scott and Kevin J Kelly

    Citation: Clinical and Molecular Allergy 2005 3:2

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  47. Content type: Research

    Beauveria bassiana is an important entomopathogenic fungus currently under development as a bio-control agent for a variety of insect pests. Although reported to be non-toxic to vertebrates, the potential allerge...

    Authors: Greg S Westwood, Shih-Wen Huang and Nemat O Keyhani

    Citation: Clinical and Molecular Allergy 2005 3:1

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  50. Content type: Review

    Osteoporosis or osteopenia occurs in about 44 million Americans, resulting in 1.5 million fragility fractures per year. The consequences of these fractures include pain, disability, depression, loss of indepen...

    Authors: E Michael Lewiecki

    Citation: Clinical and Molecular Allergy 2004 2:9

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Clinical and Molecular Allergy

ISSN: 1476-7961

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