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  1. Lime (Citrus aurantiifolia) is a plant belonging to the family of Rutaceae and to the genus Citrus. The fruit is widely used in the United States, Mexico, Southeast Asia, Latin America, but is increasingly widesp...

    Authors: Clara Alessandrello, Luca Gammeri, Serena Sanfilippo, Raffaele Cordiano, Silvia Brunetto, Marco Casciaro and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2021 19:12

    Content type: Review

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  2. The concept of personalized medicine as a diagnostic and therapeutic approach tailored to the medical needs of each patient is currently revolutionizing all fields of medicine and in particular allergology. Al...

    Authors: Cristoforo Incorvaia, Erminia Ridolo, Diego Bagnasco, Silvia Scurati and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2021 19:10

    Content type: Commentary

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  3. This case is the first report describing rapid, successful treatment of severe atopic dermatitis (AD) and comorbid type-2 inflammatory diseases in the same patient, with dupilumab treatment, with no side-effects.

    Authors: Eustachio Nettis, Lucia Masciopinto, Elisabetta Di Leo, Nicola De Candia, Marcello Albanesi, Danilo Di Bona, Nicola Quaranta and Luigi Macchia

    Citation: Clinical and Molecular Allergy 2021 19:9

    Content type: Case Report

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  4. Pruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediato...

    Authors: Eleonora Di Salvo, Alessandro Allegra, Marco Casciaro and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2021 19:8

    Content type: Review

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  5. Asthma is a common chronic condition, affecting approximately 339 million people worldwide. The main goal of the current asthma treatment guidelines is to achieve clinical control, encompassing both the patien...

    Authors: Marcello Cottini, Anita Licini, Carlo Lombardi, Diego Bagnasco, Pasquale Comberiati and Alvise Berti

    Citation: Clinical and Molecular Allergy 2021 19:7

    Content type: Review

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  6. Chronic spontaneous urticaria (CSU) is defined as urticaria with an unknown etiology which persists for more than 6 weeks. CSU is an uncomfortable cutaneous condition that occurs due to an immune-mediated infl...

    Authors: Maryam Khoshkhui, Farzaneh Iravani, Farahzad Jabbari-Azad, Hadi Zare Marzouni, Jalil Tavakkol-Afshari, Hanieh Zamani, Maryam Davarpanah, Alireza Hamidian Jahromi and Mojgan Mohammadi

    Citation: Clinical and Molecular Allergy 2021 19:6

    Content type: Research

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  7. Asthma is a chronic disease characterized by airway hyperresponsiveness, inflammation and mucus production. In Type 2 asthma, two phenotypic components are often co-expressed (eosinophilic and allergic). Eleva...

    Authors: Giorgio Walter Canonica, Francesco Blasi, Nunzio Crimi, Pierluigi Paggiaro, Alberto Papi, Francesca Fanelli, Annalisa Stassaldi and Gianluca Furneri

    Citation: Clinical and Molecular Allergy 2021 19:5

    Content type: Research

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  8. Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to pro...

    Authors: Matteo Borro, Simone Negrini, Andrew Long, Sharon Chinthrajah and Giuseppe Murdaca

    Citation: Clinical and Molecular Allergy 2021 19:4

    Content type: Letters to the Editor

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  9. Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease. Few states in developing countries have an adequate management of HAE, but none of them belongs to the former USSR area. Thi...

    Authors: Irina Guryanova, Chiara Suffritti, Debora Parolin, Andrea Zanichelli, Nastassia Ishchanka, Ekaterina Polyakova, Mikhail Belevtsev, Francesca Perego, Marco Cicardi, Yulia Zharankova, Natalya Konoplya, Sonia Caccia and Antonio Gidaro

    Citation: Clinical and Molecular Allergy 2021 19:3

    Content type: Research

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  10. Mugwort and house dust mite (HDM) are two of the most common inhalant allergens in Asia, however, whether mugwort affects polysensitized HDM+ allergic rhinitis (AR) patients has not been elucidated.

    Authors: Su Duan, Limin Zhao, Yuling Zhang, Nan Zhang, Ming Zheng, Qiqi Wang, Xu Zhang, Xiangdong Wang, Sun Ying, Claus Bachert, Luo Zhang and Feng Lan

    Citation: Clinical and Molecular Allergy 2021 19:2

    Content type: Research

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  11. Community acquired pneumonia (CAP) is a prevalent low respiratory infection. Diagnosis is based on clinical symptoms, radiologic evidence and culture. Biomarkers such as IL6, CRP and procalcitonin are helpful ...

    Authors: Mahsa Nikzad, Hamid Reza Banafshe, Mansooreh Momen-Heravi, Hamed Haddad Kashani and Maryam Shiehmorteza

    Citation: Clinical and Molecular Allergy 2021 19:1

    Content type: Research

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  12. Egg allergy is the second most prevalent form of food allergy in childhood. In spite of the evidence accumulated, inoculating egg allergy children with attenuated vaccines grown on chick embryo cell cultures, ...

    Authors: Stefania Magistà, Marcello Albanesi, Nada Chaoul, Danilo Di Bona, Elisabetta Di Leo, Eustachio Nettis, Maria Filomena Caiaffa and Luigi Macchia

    Citation: Clinical and Molecular Allergy 2020 18:21

    Content type: Case Report

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  13. Different drugs used to treat asthma, such as beta 2 agonists and inhaled steroids, may promote a higher risk of caries, dental erosion, periodontal disease and oral candidiasis. This article reviews the evide...

    Authors: Federica Gani, Marco Caminati, Fabio Bellavia, Andrea Baroso, Paolo Faccioni, Paolo Pancera, Veronica Batani and Gianenrico Senna

    Citation: Clinical and Molecular Allergy 2020 18:22

    Content type: Review

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  14. Despite availability of clinical guidelines, underdiagnosis, undertreatment, and poor adherence are still significant concerns in allergic rhinitis (AR) therapeutic management. We investigated clinical practic...

    Authors: Giovanni Passalacqua, Antonino Musarra, Gianenrico Senna, Jean Bousquet, Carmen Ferrara, Caterina Lonati and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2020 18:20

    Content type: Research

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  15. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is the most Serious Cutaneous Adverse Reaction (SCAR) often with a fatal outcome. Coronavirus Disease (COVID-19) is caused by Severe Acute Respirat...

    Authors: Carlo Maria Rossi, Flavio Niccolò Beretta, Grazia Traverso, Sandro Mancarella and Davide Zenoni

    Citation: Clinical and Molecular Allergy 2020 18:19

    Content type: Case Report

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  16. The pandemic COVID-19 abruptly exploded, taking most health professionals around the world unprepared. Italy, the first European country to be hit violently, was forced to activate the lockdown in mid-February...

    Authors: Vincenzo Patella, Gabriele Delfino, Giovanni Florio, Giuseppe Spadaro, Fulvia Chieco Bianchi, Gianerico Senna and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2020 18:18

    Content type: Review

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  17. Tranexamic acid (TXA) is a synthetic lysine analogue that is well known as antifibrinolytic agent. It can reduce blood loss in clinical use, especially in conditions where fibrinolysis or hyperfibrinolysis are...

    Authors: Giuseppe Murdaca, Monica Greco, Chiara Vassallo and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2020 18:16

    Content type: Review

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  18. Asthma affects up to nearly 40% of patients with allergic rhinitis (AR). Poor control of AR symptoms is associated with poor asthma control. The goal of this study was to evaluate the effect of AR treatment wi...

    Authors: David Price, Ludger Klimek, Gabriella Gálffy, Melanie Emmeluth, Arkady Koltun, Ferdinand Kopietz, Duc Tung Nguyen, Ranny van Weissenbruch, Wolfgang Pohl, Hans-Christian Kuhl, Glenis Scadding and Joaquim Mullol

    Citation: Clinical and Molecular Allergy 2020 18:15

    Content type: Research

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  19. COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50–69 years age group, an unfavourable factor. Females are constitutionally prone t...

    Authors: Lorenzo Salvati, Benedetta Biagioni, Emanuele Vivarelli and Paola Parronchi

    Citation: Clinical and Molecular Allergy 2020 18:14

    Content type: Review

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  20. Hypersensitivity reactions (HRs) to contrast media (CM) can be distinguished in immune-mediated (including allergic reactions) and non-immune-mediated reactions, even if clinical manifestations could be simila...

    Authors: Maria Teresa Costantino, Laura Romanini, Francesco Gaeta, Fulvio Stacul, Rocco Luigi Valluzzi, Matteo Passamonti, Patrizia Bonadonna, Giovanni Cerri, Stefano Pucci, Paolo Ricci, Eleonora Savi, Michele Galluzzo, Marina Mauro, Emanuele Grassedonio, Mona Rita Yacoub, Alfonso Reginelli…

    Citation: Clinical and Molecular Allergy 2020 18:13

    Content type: Review

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  21. COVID-19, the novel coronavirus affecting the most part of worldwide countries since early 2020, is fast increasing its prevalence around the world, representing a significant emergency for the population and ...

    Authors: Sebastiano Gangemi, Lucia Billeci and Alessandro Tonacci

    Citation: Clinical and Molecular Allergy 2020 18:12

    Content type: Correspondence

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  22. Sensitization to peanuts and hazelnuts is common among young asthmatics and can be primary or a result of cross-reactivity. Sensitization as a result of cross-reactivity to birch pollen is typically associated...

    Authors: Jennifer Johnson, Andrei Malinovschi, Jonas Lidholm, Carl Johan Petersson, Lennart Nordvall, Christer Janson, Kjell Alving and Magnus P. Borres

    Citation: Clinical and Molecular Allergy 2020 18:11

    Content type: Research

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  23. House-dust mites (HDM) allergy is the prevailing condition in subjects allergic to inhalants. Clinical studies with HDM extracts—either subcutaneous (SCIT) or sublingual (SLIT) have long been characterized by ...

    Authors: Gianfranco Vitiello, Lucia Maltagliati and Oliviero Rossi

    Citation: Clinical and Molecular Allergy 2020 18:10

    Content type: Review

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  24. Urticaria is a disorder affecting skin and mucosal tissues characterized by the occurrence of wheals, angioedema or both, the latter defining the urticaria-angioedema syndrome. It is estimated that 12–22% of t...

    Authors: Eustachio Nettis, Caterina Foti, Marina Ambrifi, Ilaria Baiardini, Leonardo Bianchi, Alessandro Borghi, Marco Caminati, Giorgio Walter Canonica, Marco Casciaro, Laura Colli, Giselda Colombo, Monica Corazza, Antonio Cristaudo, Giulia De Feo, Ornella De Pita’, Mario Di Gioacchino…

    Citation: Clinical and Molecular Allergy 2020 18:8

    Content type: Review

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  25. Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma r...

    Authors: Alireza Sharif, Hamed Haddad Kashani and Mohammad Reza Sharif

    Citation: Clinical and Molecular Allergy 2020 18:7

    Content type: Research

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  26. Fingolimod, an immunomodulatory agent, is used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Fingolimod-associated macular edema (FAME) is a known complication with an incidence of 0.4%. ...

    Authors: Rachel Husmann, John B. Davies, Malik Ghannam, Brent Berry and Praful Kelkar

    Citation: Clinical and Molecular Allergy 2020 18:3

    Content type: Case Report

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  27. Cetirizine is a second-generation antihistamine, derived from the metabolism of hydroxyzine, highly specific for the H1 receptors, and with marked antiallergic properties. Although its history began more than ...

    Authors: Giuseppe Fabio Parisi, Salvatore Leonardi, Giorgio Ciprandi, Angelo Corsico, Amelia Licari, Michele Miraglia del Giudice, Diego Peroni, Carmelo Salpietro and Gian Luigi Marseglia

    Citation: Clinical and Molecular Allergy 2020 18:2

    Content type: Review

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  28. Mulberry is a plant belonging to the family Moraceae, and genus Morus. Allergic sensitization to mulberries has been reported as both food allergy or respiratory allergy, and cross-reactivity between mulberries a...

    Authors: F. Papia, C. Incorvaia, L. Genovese, S. Gangemi and P. L. Minciullo

    Citation: Clinical and Molecular Allergy 2020 18:1

    Content type: Review

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  29. Allergic diseases are among major pediatric issues as they are highly prevalent and chronic. Therefore, identification of factors contributing to allergic disease could play a significant role in prevention of...

    Authors: Iraj Mohammadzadeh, Mohsen Haghshenas, Samaneh Asefi and Reza Alizadeh-Navaei

    Citation: Clinical and Molecular Allergy 2019 17:11

    Content type: Research

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  30. The aim of this study was to determine if the inflammation of the sympathetic ganglia (SG) in thromboangiitis obliterans (TAO) is induced by an infectious pathogen inside or if it is a reactive sterile inflamm...

    Authors: Behzad Mousazadeh, Hiva Sharebiani, Hossein Taheri, Narges Valizedeh and Bahare Fazeli

    Citation: Clinical and Molecular Allergy 2019 17:10

    Content type: Research

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  31. Common variable immunodeficiency (CVID) is the most frequent symptomatic primary antibody deficiency in adulthood and is characterized by the marked reduction of IgG and IgA serum levels. Thanks to the success...

    Authors: Antonio Pecoraro, Ludovica Crescenzi, Maria Rosaria Galdiero, Giancarlo Marone, Felice Rivellese, Francesca Wanda Rossi, Amato de Paulis, Arturo Genovese and Giuseppe Spadaro

    Citation: Clinical and Molecular Allergy 2019 17:9

    Content type: Review

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  32. Component-resolved diagnosis (CRD) allows to identify single molecular allergen components, and constitutes a routine practice in many allergy units. However, skin prick test (SPT) remains the technique of cho...

    Authors: Guillermo Til-Pérez, Claudio Carnevale, Pedro Luis Sarría-Echegaray, Diego Arancibia-Tagle, Sendy Chugo-Gordillo and Manuel David Tomás-Barberán

    Citation: Clinical and Molecular Allergy 2019 17:8

    Content type: Research

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  33. Improving the safety of subcutaneous immunotherapy (SCIT) for food allergy is necessary to reduce side effects and achieve long-term tolerance. We determined the effect of dietary supplementation with 1% non-d...

    Authors: Laura Wagenaar, Manon van Roest, Laura J. W. Kruijssen, Peter J. Simons, Louis Boon, Marlotte M. Vonk, Betty C. A. M. van Esch, Leon M. J. Knippels, Johan Garssen, Raymond H. H. Pieters and Joost J. Smit

    Citation: Clinical and Molecular Allergy 2019 17:7

    Content type: Research

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  34. There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is foun...

    Authors: Therese Sterner, Ada Uldahl, Åke Svensson, Magnus P. Borres, Sigrid Sjölander, Alf Tunsäter, Jonas Björk, Cecilia Svedman, Magnus Bruze, Laura von Kobyletzki and Hampus Kiotseridis

    Citation: Clinical and Molecular Allergy 2019 17:6

    Content type: Research

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  35. Atopic dermatitis is a chronic inflammatory skin disorder, whose symptoms and severity grossly depend on individual trigger factors. The majority of patients are satisfactorily treated with emollients together...

    Authors: Susanna Bormioli, Andrea Matucci, Laura Dies, Francesca Nencini, Francesca Grosso, Enrico Maggi and Alessandra Vultaggio

    Citation: Clinical and Molecular Allergy 2019 17:5

    Content type: Case Report

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  36. GST belongs to a super family of phase II detoxification enzyme and it plays an important role in preventing the damage that may occur due to reactive water-soluble compounds generated by the association of re...

    Authors: Israa Hussein Hamzah, Farha A. Ali Shafi, Sahar A. H. Al Sharqi and Suaad Almas Brakhas

    Citation: Clinical and Molecular Allergy 2019 17:4

    Content type: Research

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  37. Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently presents with dysfunction or loss of the sense of smell, resulting in a significant impairment in quality of life. The medical treatments currently ...

    Authors: Carlo Cavaliere, Cristoforo Incorvaia, Franco Frati, Daniela Messineo, Mario Ciotti, Antonio Greco, Marco de Vincentiis and Simonetta Masieri

    Citation: Clinical and Molecular Allergy 2019 17:3

    Content type: Case Report

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  38. A growing use of complementary alternative medicine (CAM) has been found in Europe as well in Italy for chronic diseases, including the allergic rhinitis. The study aims at investigating the prevalence and the...

    Authors: G. Bonizzoni, M. Caminati, E. Ridolo, M. Landi, M. T. Ventura, C. Lombardi, G. Senna, M. Crivellaro and F. Gani

    Citation: Clinical and Molecular Allergy 2019 17:2

    Content type: Research

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  39. Proton pump inhibitors (PPIs) are drugs capable of blocking the gastric pump H,K-ATPase in order to inhibit gastric acid secretion. Omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole belong t...

    Authors: Marco Casciaro, Michele Navarra, Giuseppina Inferrera, Marta Liotta, Sebastiano Gangemi and Paola Lucia Minciullo

    Citation: Clinical and Molecular Allergy 2019 17:1

    Content type: Research

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  40. According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma.

    Authors: Federica Novelli, Elena Bacci, Manuela Latorre, Veronica Seccia, Maria Laura Bartoli, Silvana Cianchetti, Federico Lorenzo Dente, Antonella Di Franco, Alessandro Celi and Pierluigi Paggiaro

    Citation: Clinical and Molecular Allergy 2018 16:25

    Content type: Research

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  41. Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized.

    Authors: Gino A. Vena, Nicoletta Cassano, E. Di Leo, G. F. Calogiuri and Eustachio Nettis

    Citation: Clinical and Molecular Allergy 2018 16:24

    Content type: Review

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  42. Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggri...

    Authors: Zafar Rasheed, Khaled Zedan, Ghada Bin Saif, Ragaa H. Salama, Tarek Salem, Ahmed A. Ahmed, Alaa Abd El-Moniem, Maha Elkholy, Ahmad A. Al Robaee and Abdullateef A. Alzolibani

    Citation: Clinical and Molecular Allergy 2018 16:23

    Content type: Research

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