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  1. Ifosfamide is an alkylating agent used in the treatment of a wide range of tumours. Because of known side effects it is usually administered in combination with mesna, a thiol agent with uroprotective activity...

    Authors: Ana Delgado-Prada, Julián Borrás, Roxana Farzanegan, María Cruz Torres Gorriz, Adrián Germán-Sánchez, Raquel Cervera Aznar, Isabela Raducan, Jose Vicente Castelló, Alfredo Sanchez-Hernandez and Ernesto Enrique
    Citation: Clinical and Molecular Allergy 2022 20:7
  2. Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects...

    Authors: Eustachio Nettis, Luisa Brussino, Vincenzo Patella, Laura Bonzano, Aikaterini Detoraki, Elisabetta Di Leo, Maria Maddalena Sirufo, Cristiano Caruso, Fabio Lodi Rizzini, Mariaelisabetta Conte, Mona-Rita Yacoub, Massimo Triggiani, Erminia Ridolo, Luigi Macchia, Giovanni Rolla, Raffaele Brancaccio…
    Citation: Clinical and Molecular Allergy 2022 20:6
  3. Type I hypersensitivity (allergic reaction) is an unsuitable or overreactive immune response to an allergen due to cross-link immunoglobulin E (IgE) antibodies bound to its high-affinity IgE receptors (FcεRIs)...

    Authors: Amin Moradi Hasan-Abad, Mohsen Mohammadi, Hamed Mirzaei, Mohsen Mehrabi, Hossein Motedayyen and Reza Arefnezhad
    Citation: Clinical and Molecular Allergy 2022 20:5
  4. Anaphylaxis occurs in up to 3.5% of hymenoptera stings and can be a life-threatening emergency. Venom immunotherapy (VIT) provides excellent protection from further episodes of anaphylaxis and is well tolerate...

    Authors: Antonia Glaeser, Christoph Müller and Sebastian Bode
    Citation: Clinical and Molecular Allergy 2022 20:4
  5. Allergic rhinitis is a widespread disorder across the globe. The Shirazi thyme (Zataria multiflora) has been shown to have considerable antioxidant and anti-inflammatory properties. This study assessed the effect...

    Authors: Nazila Ariaee, Yaser Yadegari, Mohamad Shabestari, Javad Asili, Maryam Panahi, Jalal Ghorbani and Farahzad Jabbari
    Citation: Clinical and Molecular Allergy 2022 20:3
  6. Microbiome science deals with the development of diseases that are derived from the interaction between the host immune system and microbes. Microbiome disturbance or dysbiosis has been increasingly recognized...

    Authors: Aisha Alamri and Suzan A. AlKhater
    Citation: Clinical and Molecular Allergy 2022 20:2
  7. Recently, a continuous growth for both neurodevelopmental and atopic diseases’ incidence was seen throughout the world. Notably, autism spectrum disorders (ASD) and atopic dermatitis (AD) attracted the attenti...

    Authors: Alessandro Tonacci, Giovanni Pioggia and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:27
  8. Allergic and immunologic skin diseases negatively impact the quality of life (QoL) of affected patients with detrimental consequences. Nonetheless, in everyday clinical practice the evaluation of QoL is often ...

    Authors: Ester Di Agosta, Lorenzo Salvati, Monica Corazza, Ilaria Baiardini, Francesca Ambrogio, Luisa Angileri, Elettra Antonelli, Federica Belluzzo, Domenico Bonamonte, Laura Bonzano, Raffaele Brancaccio, Paolo Custurone, Aurora De Marco, Aikaterini Detoraki, Adriana Di Guida, Elisabetta Di Leo…
    Citation: Clinical and Molecular Allergy 2021 19:26
  9. Dipeptidyl peptidase-IV (DPP-IV) inhibitors, also known as gliptins, are a class of oral antidiabetic agents. Postmarketing reports have documented the occurrence of angioedema in patients treated with gliptin...

    Authors: Nicoletta Cassano, Eustachio Nettis, Elisabetta Di Leo, Francesca Ambrogio, Gino A. Vena and Caterina Foti
    Citation: Clinical and Molecular Allergy 2021 19:24
  10. Asthma, and severe asthma in particular, is often managed within a specialized field with allergists and clinical immunologists playing a leading role. In this respect, the National Scientific Society SIAAIC (Soc...

    Authors: G. Carli, A. Farsi, S. Bormioli, E. Ridolo, F. Fassio, S. Pucci, M. Montevecchi, M. Riparbelli, L. Cosmi, P. Parronchi and O. Rossi
    Citation: Clinical and Molecular Allergy 2021 19:22
  11. Human plasmacytoid dendritic cells (pDC) have a dual role as interferon-producing and antigen-presenting cells. Their relevance for allergic diseases is controversial. and the impact of pDC on allergic immune ...

    Authors: Noelle Zurmühl, Anna Schmitt, Ulrike Formentini, Johannes Weiss, Heike Appel, Klaus-Michael Debatin and Dorit Fabricius
    Citation: Clinical and Molecular Allergy 2021 19:23
  12. The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory s...

    Authors: Mohsen Nabi-Afjadi, Hadis Karami, Kaveh Goudarzi, Iraj Alipourfard and Elham Bahreini
    Citation: Clinical and Molecular Allergy 2021 19:21
  13. The observation of patients hospitalized for coronavirus disease (COVID-19) led us to note a lower prevalence of patients affected by chronic respiratory disease, in particular asthmatic patients, compared to ...

    Authors: Fabiana Furci, Marco Caminati, Gianenrico Senna and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:19
  14. There has been little investigation on how guidelines for allergic rhinitis (AR) treatment are applied in current clinical practice. We aimed to analyze prescription trends and patterns for AR treatment accord...

    Authors: Jaemin Son, Eun-San Kim, Hee-seung Choi, In-Hyuk Ha, Donghyo Lee and Yoon Jae Lee
    Citation: Clinical and Molecular Allergy 2021 19:20
  15. Egg allergy is one of the most frequent food allergies in childhood while adult onset of egg allergy is a rare condition.

    Authors: Elisa Maria Cremonte, Eugenia Galdi, Chiara Roncallo, Elisa Boni and Luigi Giovanni Cremonte
    Citation: Clinical and Molecular Allergy 2021 19:17
  16. Interleukin-33 (IL-33) is a 30KDa protein, which belongs to the Interleukin-1 cytokine family. It is a crucial regulator of innate and adaptive immune responses. This interleukin is additionally involved in th...

    Authors: Eleonora Di Salvo, Marco Casciaro and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:18
  17. COVID-19 has represented an unprecedented challenge to be faced also concerning the spread of information, with scientific literature being often the sole source of trustworthy knowledge for the global communi...

    Authors: Alessandro Tonacci, Sara Genovese, Giovanni Pioggia and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:16
  18. Processionary caterpillar (PC), also named Thaumatopea pityocampa, has been reported to cause hypersensitivity reactions after contact with a toxin contained in hair-like bristles which cover this insect. Occupat...

    Authors: Luisa Ricciardi, Concetto Giorgianni, Giusi Briguglio, Sebastiano Gangemi and Giovanna Spatari
    Citation: Clinical and Molecular Allergy 2021 19:15
  19. Specific IgE (sIgE) against the peanut component Arachis hypogaea (Ara h) 2 has been shown to be the most important allergen to discriminate between peanut allergy and peanut tolerance. Several studies determi...

    Authors: H. K. Brand, M. W. J. Schreurs, J. A. M. Emons, R. Gerth van Wijk, H. de Groot and N. J. T. Arends
    Citation: Clinical and Molecular Allergy 2021 19:14
  20. Measurements of allergen-specific IgE antibodies with different manufacturers’ assays show modest or poor agreement. This study compares analytical performance of specific IgE tests for whole allergen extracts...

    Authors: Komei Ito and Kazunori Tagami
    Citation: Clinical and Molecular Allergy 2021 19:13
  21. Lime (Citrus aurantiifolia) is a plant belonging to the family of Rutaceae and to the genus Citrus. The fruit is widely used in the United States, Mexico, Southeast Asia, Latin America, but is increasingly widesp...

    Authors: Clara Alessandrello, Luca Gammeri, Serena Sanfilippo, Raffaele Cordiano, Silvia Brunetto, Marco Casciaro and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:12
  22. The concept of personalized medicine as a diagnostic and therapeutic approach tailored to the medical needs of each patient is currently revolutionizing all fields of medicine and in particular allergology. Al...

    Authors: Cristoforo Incorvaia, Erminia Ridolo, Diego Bagnasco, Silvia Scurati and Giorgio Walter Canonica
    Citation: Clinical and Molecular Allergy 2021 19:10
  23. This case is the first report describing rapid, successful treatment of severe atopic dermatitis (AD) and comorbid type-2 inflammatory diseases in the same patient, with dupilumab treatment, with no side-effects.

    Authors: Eustachio Nettis, Lucia Masciopinto, Elisabetta Di Leo, Nicola De Candia, Marcello Albanesi, Danilo Di Bona, Nicola Quaranta and Luigi Macchia
    Citation: Clinical and Molecular Allergy 2021 19:9
  24. Pruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediato...

    Authors: Eleonora Di Salvo, Alessandro Allegra, Marco Casciaro and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:8
  25. Asthma is a common chronic condition, affecting approximately 339 million people worldwide. The main goal of the current asthma treatment guidelines is to achieve clinical control, encompassing both the patien...

    Authors: Marcello Cottini, Anita Licini, Carlo Lombardi, Diego Bagnasco, Pasquale Comberiati and Alvise Berti
    Citation: Clinical and Molecular Allergy 2021 19:7
  26. Chronic spontaneous urticaria (CSU) is defined as urticaria with an unknown etiology which persists for more than 6 weeks. CSU is an uncomfortable cutaneous condition that occurs due to an immune-mediated infl...

    Authors: Maryam Khoshkhui, Farzaneh Iravani, Farahzad Jabbari-Azad, Hadi Zare Marzouni, Jalil Tavakkol-Afshari, Hanieh Zamani, Maryam Davarpanah, Alireza Hamidian Jahromi and Mojgan Mohammadi
    Citation: Clinical and Molecular Allergy 2021 19:6
  27. Asthma is a chronic disease characterized by airway hyperresponsiveness, inflammation and mucus production. In Type 2 asthma, two phenotypic components are often co-expressed (eosinophilic and allergic). Eleva...

    Authors: Giorgio Walter Canonica, Francesco Blasi, Nunzio Crimi, Pierluigi Paggiaro, Alberto Papi, Francesca Fanelli, Annalisa Stassaldi and Gianluca Furneri
    Citation: Clinical and Molecular Allergy 2021 19:5
  28. Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to pro...

    Authors: Matteo Borro, Simone Negrini, Andrew Long, Sharon Chinthrajah and Giuseppe Murdaca
    Citation: Clinical and Molecular Allergy 2021 19:4
  29. Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease. Few states in developing countries have an adequate management of HAE, but none of them belongs to the former USSR area. Thi...

    Authors: Irina Guryanova, Chiara Suffritti, Debora Parolin, Andrea Zanichelli, Nastassia Ishchanka, Ekaterina Polyakova, Mikhail Belevtsev, Francesca Perego, Marco Cicardi, Yulia Zharankova, Natalya Konoplya, Sonia Caccia and Antonio Gidaro
    Citation: Clinical and Molecular Allergy 2021 19:3
  30. Mugwort and house dust mite (HDM) are two of the most common inhalant allergens in Asia, however, whether mugwort affects polysensitized HDM+ allergic rhinitis (AR) patients has not been elucidated.

    Authors: Su Duan, Limin Zhao, Yuling Zhang, Nan Zhang, Ming Zheng, Qiqi Wang, Xu Zhang, Xiangdong Wang, Sun Ying, Claus Bachert, Luo Zhang and Feng Lan
    Citation: Clinical and Molecular Allergy 2021 19:2
  31. Community acquired pneumonia (CAP) is a prevalent low respiratory infection. Diagnosis is based on clinical symptoms, radiologic evidence and culture. Biomarkers such as IL6, CRP and procalcitonin are helpful ...

    Authors: Mahsa Nikzad, Hamid Reza Banafshe, Mansooreh Momen-Heravi, Hamed Haddad Kashani and Maryam Shiehmorteza
    Citation: Clinical and Molecular Allergy 2021 19:1
  32. Egg allergy is the second most prevalent form of food allergy in childhood. In spite of the evidence accumulated, inoculating egg allergy children with attenuated vaccines grown on chick embryo cell cultures, ...

    Authors: Stefania Magistà, Marcello Albanesi, Nada Chaoul, Danilo Di Bona, Elisabetta Di Leo, Eustachio Nettis, Maria Filomena Caiaffa and Luigi Macchia
    Citation: Clinical and Molecular Allergy 2020 18:21
  33. Different drugs used to treat asthma, such as beta 2 agonists and inhaled steroids, may promote a higher risk of caries, dental erosion, periodontal disease and oral candidiasis. This article reviews the evide...

    Authors: Federica Gani, Marco Caminati, Fabio Bellavia, Andrea Baroso, Paolo Faccioni, Paolo Pancera, Veronica Batani and Gianenrico Senna
    Citation: Clinical and Molecular Allergy 2020 18:22
  34. Despite availability of clinical guidelines, underdiagnosis, undertreatment, and poor adherence are still significant concerns in allergic rhinitis (AR) therapeutic management. We investigated clinical practic...

    Authors: Giovanni Passalacqua, Antonino Musarra, Gianenrico Senna, Jean Bousquet, Carmen Ferrara, Caterina Lonati and Giorgio Walter Canonica
    Citation: Clinical and Molecular Allergy 2020 18:20
  35. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is the most Serious Cutaneous Adverse Reaction (SCAR) often with a fatal outcome. Coronavirus Disease (COVID-19) is caused by Severe Acute Respirat...

    Authors: Carlo Maria Rossi, Flavio Niccolò Beretta, Grazia Traverso, Sandro Mancarella and Davide Zenoni
    Citation: Clinical and Molecular Allergy 2020 18:19
  36. The pandemic COVID-19 abruptly exploded, taking most health professionals around the world unprepared. Italy, the first European country to be hit violently, was forced to activate the lockdown in mid-February...

    Authors: Vincenzo Patella, Gabriele Delfino, Giovanni Florio, Giuseppe Spadaro, Fulvia Chieco Bianchi, Gianerico Senna and Mario Di Gioacchino
    Citation: Clinical and Molecular Allergy 2020 18:18
  37. Tranexamic acid (TXA) is a synthetic lysine analogue that is well known as antifibrinolytic agent. It can reduce blood loss in clinical use, especially in conditions where fibrinolysis or hyperfibrinolysis are...

    Authors: Giuseppe Murdaca, Monica Greco, Chiara Vassallo and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2020 18:16
  38. Asthma affects up to nearly 40% of patients with allergic rhinitis (AR). Poor control of AR symptoms is associated with poor asthma control. The goal of this study was to evaluate the effect of AR treatment wi...

    Authors: David Price, Ludger Klimek, Gabriella Gálffy, Melanie Emmeluth, Arkady Koltun, Ferdinand Kopietz, Duc Tung Nguyen, Ranny van Weissenbruch, Wolfgang Pohl, Hans-Christian Kuhl, Glenis Scadding and Joaquim Mullol
    Citation: Clinical and Molecular Allergy 2020 18:15
  39. COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50–69 years age group, an unfavourable factor. Females are constitutionally prone t...

    Authors: Lorenzo Salvati, Benedetta Biagioni, Emanuele Vivarelli and Paola Parronchi
    Citation: Clinical and Molecular Allergy 2020 18:14
  40. Hypersensitivity reactions (HRs) to contrast media (CM) can be distinguished in immune-mediated (including allergic reactions) and non-immune-mediated reactions, even if clinical manifestations could be simila...

    Authors: Maria Teresa Costantino, Laura Romanini, Francesco Gaeta, Fulvio Stacul, Rocco Luigi Valluzzi, Matteo Passamonti, Patrizia Bonadonna, Giovanni Cerri, Stefano Pucci, Paolo Ricci, Eleonora Savi, Michele Galluzzo, Marina Mauro, Emanuele Grassedonio, Mona Rita Yacoub, Alfonso Reginelli…
    Citation: Clinical and Molecular Allergy 2020 18:13
  41. COVID-19, the novel coronavirus affecting the most part of worldwide countries since early 2020, is fast increasing its prevalence around the world, representing a significant emergency for the population and ...

    Authors: Sebastiano Gangemi, Lucia Billeci and Alessandro Tonacci
    Citation: Clinical and Molecular Allergy 2020 18:12
  42. Sensitization to peanuts and hazelnuts is common among young asthmatics and can be primary or a result of cross-reactivity. Sensitization as a result of cross-reactivity to birch pollen is typically associated...

    Authors: Jennifer Johnson, Andrei Malinovschi, Jonas Lidholm, Carl Johan Petersson, Lennart Nordvall, Christer Janson, Kjell Alving and Magnus P. Borres
    Citation: Clinical and Molecular Allergy 2020 18:11
  43. House-dust mites (HDM) allergy is the prevailing condition in subjects allergic to inhalants. Clinical studies with HDM extracts—either subcutaneous (SCIT) or sublingual (SLIT) have long been characterized by ...

    Authors: Gianfranco Vitiello, Lucia Maltagliati and Oliviero Rossi
    Citation: Clinical and Molecular Allergy 2020 18:10


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