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  1. Content type: Case Report

    Kounis syndrome (KS) has been described as the coincidental occurrence of acute coronary syndromes during an allergic reaction with cardiac anaphylaxis. It is caused by inflammatory mediators released after ex...

    Authors: Luisa Ricciardi, Fabiana Furci, Marco Casciaro, Eleonora Di Salvo, Mariateresa Cristani, Valeria Tigano, Paola Lucia Minciullo and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:21

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  2. Content type: Review

    According to the World Health Organization, air pollution is closely associated with climate change and, in particular, with global warming. In addition to melting of ice and snow, rising sea level, and floodi...

    Authors: Vincenzo Patella, Giovanni Florio, Diomira Magliacane, Ada Giuliano, Maria Angiola Crivellaro, Daniela Di Bartolomeo, Arturo Genovese, Mario Palmieri, Amedeo Postiglione, Erminia Ridolo, Cristina Scaletti, Maria Teresa Ventura and Anna Zollo

    Citation: Clinical and Molecular Allergy 2018 16:20

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  3. Content type: Case Report

    New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our stud...

    Authors: Stefania Isola, Fabiana Furci and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:19

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  4. Content type: Case Report

    Severe aortic valve stenosis is one of the most common cause of mortality in adult patients affected with metabolic syndrome, a condition associated with an active inflammatory process involving also mast cell...

    Authors: Laura M. Losappio, Corrado Mirone, Michel Chevallard, Laura Farioli, Fabrizio De Luca and Elide A. Pastorello

    Citation: Clinical and Molecular Allergy 2018 16:17

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  5. Content type: Research

    Sublingual immunotherapy (SLIT) is effective, tolerable, and convenient for many allergic patients. Still, real-world evidence is scarce and the aim of this study is to assess the patient reported outcome of t...

    Authors: Christer Janson, Fredrik Sundbom, Peter Arvidsson and Mary Kämpe

    Citation: Clinical and Molecular Allergy 2018 16:14

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  6. Content type: Correspondence

    Allergic asthma is an inflammatory disorder of the airways that results from inappropriate production of IgE against harmless, environmental antigens. Sequestration of free IgE using humanized IgG anti-IgE is ...

    Authors: Sonali J. Bracken, Alexander J. Adami, Ektor Rafti, Craig M. Schramm and Adam P. Matson

    Citation: Clinical and Molecular Allergy 2018 16:13

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  7. Content type: Research

    Based on meta-analyses results, it is currently acknowledged that there is an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) undergoing inhaled corticosteroids (ICS) ...

    Authors: Erminia Ridolo, Cristoforo Incorvaia, Irene Martignago, Laura Pessina, Fulvio Lauretani, Luciano Loperfido, Gian Galeazzo Riario-Sforza, Annalisa Broglia, Bruna L. Gritti and Lorenzo Panella

    Citation: Clinical and Molecular Allergy 2018 16:12

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  8. Content type: Review

    Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes,...

    Authors: Marco Casciaro, Eleonora Di Salvo, Teresa Brizzi, Carmelo Rodolico and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:11

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  9. Content type: Research

    Hymenoptera sting reactions are among life-threatening causes of allergy. Several epidemiology studies have assessed the risk of these kind of reactions, among the general population, around 3% of adults. This...

    Authors: Luisa Ricciardi, Francesco Papia, Giuseppe Cataldo, Mario Giorgianni, Giovanna Spatari and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:8

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  10. Content type: Case report

    Parasite infections stimulate total and specific IgE production that, in the case of Toxocara canis infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar sympt...

    Authors: Rosanna Qualizza, Laura M Losappio and Fabiana Furci

    Citation: Clinical and Molecular Allergy 2018 16:10

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  11. Content type: Research

    The use of drugs in the elderly is very extensive because of the frequent occurrence of chronic diseases. Adverse drug reactions (ADRs) commonly occur in geriatric patients receiving multiple therapeutic regim...

    Authors: Maria Teresa Ventura, Elisa Boni, Rosa Cecere, Rosalba Buquicchio, Gian Franco Calogiuri, Irene Martignago, Cristoforo Incorvaia and Erminia Ridolo

    Citation: Clinical and Molecular Allergy 2018 16:7

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  12. Content type: Review

    Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been includ...

    Authors: Boaz Palterer, Gianfranco Vitiello, Alessia Carraresi, Maria Grazia Giudizi, Daniele Cammelli and Paola Parronchi

    Citation: Clinical and Molecular Allergy 2018 16:5

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  13. Content type: Review

    Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the prog...

    Authors: Matteo Ferrando, Francesca Racca, Lorena Nascimento Girardi Madeira, Enrico Heffler, Giovanni Passalacqua, Francesca Puggioni, Niccolò Stomeo and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2018 16:6

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  14. Content type: Research

    Allergic Rhinitis (AR) is a high-prevalence disease. In Europe about 25% of the general population is affected, and in Italy the prevalence is estimated to be 19.8%. The Allergic Rhinitis and its Impact on Ast...

    Authors: Federica Gani, Carlo Lombardi, Laura Barrocu, Massimo Landi, Erminia Ridolo, Massimo Bugiani, Giovanni Rolla, Gianenrico Senna and Giovanni Passalacqua

    Citation: Clinical and Molecular Allergy 2018 16:4

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  15. Content type: Research

    The query “are there animals at home?” is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studi...

    Authors: G. Liccardi, L. Calzetta, G. Baldi, A. Berra, L. Billeri, M. Caminati, P. Capano, E. Carpentieri, A. Ciccarelli, M. A. Crivellaro, M. Cutajar, M. D’Amato, I. Folletti, F. Gani, D. Gargano, D. Giannattasio…

    Citation: Clinical and Molecular Allergy 2018 16:3

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  16. Content type: Research

    Hymenoptera venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account f...

    Authors: Marcello Albanesi, Andrea Nico, Alessandro Sinisi, Lucia Giliberti, Maria Pia Rossi, Margherita Rossini, Georgios Kourtis, Anna Simona Rucco, Filomena Loconte, Loredana Muolo, Marco Zurlo, Danilo Di Bona, Maria Filomena Caiaffa and Luigi Macchia

    Citation: Clinical and Molecular Allergy 2018 16:2

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  17. Content type: Review

    The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention...

    Authors: Roberto Paganelli, Claudia Petrarca and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2018 16:1

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  18. Content type: Review

    The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescen...

    Authors: Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi and Rosalba Buquicchio

    Citation: Clinical and Molecular Allergy 2017 15:21

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  19. Content type: Research

    Allergic diseases are on the rise in many parts of the world, including the Asia–Pacific (APAC) region. Second-generation antihistamines are the first-line treatment option in the management of allergic rhinit...

    Authors: Marysia Tiongco Recto, Ma. Teresita Gabriel, Kanokvalai Kulthanan, Pongsakorn Tantilipikorn, Derrick Chen-Wee Aw, Tak Hong Lee, Ch’ng Chin Chwen, Somasundran Mutusamy, Nguyen Trong Hao, Vo Thanh Quang and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2017 15:19

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  20. Content type: Research

    IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The...

    Authors: Jenny van Odijk, Sigrid Sjölander, Peter Brostedt, Magnus P. Borres and Hillevi Englund

    Citation: Clinical and Molecular Allergy 2017 15:18

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  21. Content type: Review

    Asthma, allergic rhinitis (AR) and atopic dermatitis are very common in young people, but in the latest decades it was increasingly recognized that also individuals of higher ages, including the population ove...

    Authors: Erminia Ridolo, Anti Rogkakou, Maria Teresa Ventura, Irene Martignago, Cristoforo Incorvaia, Gabriele Di Lorenzo and Giovanni Passalacqua

    Citation: Clinical and Molecular Allergy 2017 15:17

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  22. Content type: Review

    Anticonvulsant hypersensitivity syndrome represents a rare but potentially fatal kind of adverse drug reaction. This clinical picture often hampers the flexibility with which alternative anticonvulsants or eve...

    Authors: Fabrizio De Luca, Laura Michelina Losappio, Corrado Mirone, Jan Walter Schroeder, Antonella Citterio, Maria Gloria Aversano, Joseph Scibilia and Elide Anna Pastorello

    Citation: Clinical and Molecular Allergy 2017 15:16

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  23. Content type: Research

    Sublingual immunotherapy (SLIT) is a feasible option to classical subcutaneous immunotherapy to treat respiratory allergy and is increasingly prescribed in Europe. However, the lack of reimbursement may limit ...

    Authors: Ilaria Massaro, Oliviero Rossi, Cristoforo Incorvaia and Carlo Lombardi

    Citation: Clinical and Molecular Allergy 2017 15:15

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  24. Content type: Case Report

    Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity react...

    Authors: Malik Ghannam, Shaden Mansour, Aya Nabulsi and Qusay Abdoh

    Citation: Clinical and Molecular Allergy 2017 15:14

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  25. Content type: Review

    Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characte...

    Authors: Egidio Imbalzano, Sebastiano Quartuccio, Eleonora Di Salvo, Teresa Crea, Marco Casciaro and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2017 15:12

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  26. Content type: Research

    Early recognition of inflammatory markers and their relation to asthma, adverse drug reactions, allergic rhinitis, atopic dermatitis and other allergic diseases is an important goal in allergy. The vast majori...

    Authors: Gennaro Tartarisco, Alessandro Tonacci, Paola Lucia Minciullo, Lucia Billeci, Giovanni Pioggia, Cristoforo Incorvaia and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2017 15:10

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  27. Content type: Review

    Hypersensitivity to para-phenylenediamine (PPD) and related compounds induced by temporary black henna tattoos has become a serious health problem worldwide. Different patterns of sensitization with various cl...

    Authors: Gianfranco Calogiuri, Elisabetta Di Leo, Lavjay Butani, Stefano Pizzimenti, Cristoforo Incorvaia, Luigi Macchia and Eustachio Nettis

    Citation: Clinical and Molecular Allergy 2017 15:8

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  28. Content type: Commentary

    Even if severe asthma (SA) accounts for 5–10% of all cases of the disease, it is currently a crucial unmet need, owing its difficult clinical management and its high social costs. For this reason several netwo...

    Authors: G. Senna, M. Guerriero, P. L. Paggiaro, F. Blasi, M. Caminati, E. Heffler, M. Latorre and G. W. Canonica

    Citation: Clinical and Molecular Allergy 2017 15:9

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  29. Content type: Research

    Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sub...

    Authors: I. Djuric-Filipovic, Marco Caminati, D. Filipovic, C. Salvottini and Z. Zivkovic

    Citation: Clinical and Molecular Allergy 2017 15:7

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  30. Content type: Review

    Allergic rhinitis has a very high burden regarding both direct and indirect costs. This makes essential in the management of AR to reduce the clinical severity of the disease and thus to lessen its costs. This...

    Authors: Carlo Lombardi, Valerie Melli, Cristoforo Incorvaia and Erminia Ridolo

    Citation: Clinical and Molecular Allergy 2017 15:5

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  31. Content type: Review

    Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitiu...

    Authors: Gian Galeazzo Riario Sforza and Androula Marinou

    Citation: Clinical and Molecular Allergy 2017 15:6

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  32. Content type: Research

    Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physicia...

    Authors: Mizuho Nagao, Magnus P. Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel and Takao Fujisawa

    Citation: Clinical and Molecular Allergy 2017 15:4

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  33. Content type: Case Report

    Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may ...

    Authors: Fabiano Di Marco, Giuseppe Francesco Sferrazza Papa, Dejan Radovanovic and Pierachille Santus

    Citation: Clinical and Molecular Allergy 2017 15:3

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  34. Content type: Review

    Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is pa...

    Authors: Maria Teresa Ventura, Nicola Scichilone, Roberto Paganelli, Paola Lucia Minciullo, Vincenzo Patella, Matteo Bonini, Giovanni Passalacqua, Carlo Lombardi, Livio Simioni, Erminia Ridolo, Stefano R. Del Giacco, Sebastiano Gangemi and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2017 15:2

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  35. Content type: Research

    Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX® is the most documented product in terms of safety and efficacy. T...

    Authors: Tomás Chivato, Pedro Álvarez-Calderón, Carmen Panizo, Ricardo Abengozar, César Alías, Ali Al-Baech, José Arias-Irigoyen, M. José Caballero, Lluis Conill, Silvia de Miguel, Rafael Laguna, Joan Martínez-Benazet, Francisco Matoses, Jose Camilo Martínez-Alonso, Lourdes Mendizábal, Celsa Pérez-Carral…

    Citation: Clinical and Molecular Allergy 2017 15:1

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  36. Content type: Review

    The tapeworm Taenia (T.) solium can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tis...

    Authors: Paola Lucia Minciullo, Antonio Cascio, Stefania Isola and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2016 14:18

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  37. Content type: Review

    Eosinophilic diseases of the gastrointestinal tract, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), are rare chronic pathologies of the digestive system, with an immuno-mediat...

    Authors: Erminia Ridolo, Valerie Melli, Gianluigi De’ Angelis and Irene Martignago

    Citation: Clinical and Molecular Allergy 2016 14:17

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  38. Content type: Research

    CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that ch...

    Authors: Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato and Lorenzo Cosmi

    Citation: Clinical and Molecular Allergy 2016 14:16

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  39. Content type: Research

    The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal enviro...

    Authors: Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Antonio Lobasso, Filomena Napolitano, Francescopaolo Granata, Carmine Selleri and Amato de Paulis

    Citation: Clinical and Molecular Allergy 2016 14:15

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  40. Content type: Case Report

    Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involveme...

    Authors: Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Donatella Sangari, Santa Cirmi, Roneka L. Ravenell, Michele Navarra, Gianfilippo Bagnato and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2016 14:13

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  41. Content type: Review

    This meta-analysis compared the health-related quality of life (HRQL) of patients with allergic rhinitis (AR) and/or allergic asthma (AA) caused by perennial house dust mite (HDM) versus AR and/or AA caused by...

    Authors: A. Linneberg, K. Dam Petersen, J. Hahn-Pedersen, E. Hammerby, N. Serup-Hansen and N. Boxall

    Citation: Clinical and Molecular Allergy 2016 14:12

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