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  1. Content type: Research

    Allergic diseases are among major pediatric issues as they are highly prevalent and chronic. Therefore, identification of factors contributing to allergic disease could play a significant role in prevention of...

    Authors: Iraj Mohammadzadeh, Mohsen Haghshenas, Samaneh Asefi and Reza Alizadeh-Navaei

    Citation: Clinical and Molecular Allergy 2019 17:11

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  2. Content type: Research

    The aim of this study was to determine if the inflammation of the sympathetic ganglia (SG) in thromboangiitis obliterans (TAO) is induced by an infectious pathogen inside or if it is a reactive sterile inflamm...

    Authors: Behzad Mousazadeh, Hiva Sharebiani, Hossein Taheri, Narges Valizedeh and Bahare Fazeli

    Citation: Clinical and Molecular Allergy 2019 17:10

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  3. Content type: Review

    Common variable immunodeficiency (CVID) is the most frequent symptomatic primary antibody deficiency in adulthood and is characterized by the marked reduction of IgG and IgA serum levels. Thanks to the success...

    Authors: Antonio Pecoraro, Ludovica Crescenzi, Maria Rosaria Galdiero, Giancarlo Marone, Felice Rivellese, Francesca Wanda Rossi, Amato de Paulis, Arturo Genovese and Giuseppe Spadaro

    Citation: Clinical and Molecular Allergy 2019 17:9

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  4. Content type: Research

    Component-resolved diagnosis (CRD) allows to identify single molecular allergen components, and constitutes a routine practice in many allergy units. However, skin prick test (SPT) remains the technique of cho...

    Authors: Guillermo Til-Pérez, Claudio Carnevale, Pedro Luis Sarría-Echegaray, Diego Arancibia-Tagle, Sendy Chugo-Gordillo and Manuel David Tomás-Barberán

    Citation: Clinical and Molecular Allergy 2019 17:8

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  5. Content type: Research

    Improving the safety of subcutaneous immunotherapy (SCIT) for food allergy is necessary to reduce side effects and achieve long-term tolerance. We determined the effect of dietary supplementation with 1% non-d...

    Authors: Laura Wagenaar, Manon van Roest, Laura J. W. Kruijssen, Peter J. Simons, Louis Boon, Marlotte M. Vonk, Betty C. A. M. van Esch, Leon M. J. Knippels, Johan Garssen, Raymond H. H. Pieters and Joost J. Smit

    Citation: Clinical and Molecular Allergy 2019 17:7

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  6. Content type: Research

    There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is foun...

    Authors: Therese Sterner, Ada Uldahl, Åke Svensson, Magnus P. Borres, Sigrid Sjölander, Alf Tunsäter, Jonas Björk, Cecilia Svedman, Magnus Bruze, Laura von Kobyletzki and Hampus Kiotseridis

    Citation: Clinical and Molecular Allergy 2019 17:6

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  7. Content type: Case Report

    Atopic dermatitis is a chronic inflammatory skin disorder, whose symptoms and severity grossly depend on individual trigger factors. The majority of patients are satisfactorily treated with emollients together...

    Authors: Susanna Bormioli, Andrea Matucci, Laura Dies, Francesca Nencini, Francesca Grosso, Enrico Maggi and Alessandra Vultaggio

    Citation: Clinical and Molecular Allergy 2019 17:5

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  8. Content type: Research

    GST belongs to a super family of phase II detoxification enzyme and it plays an important role in preventing the damage that may occur due to reactive water-soluble compounds generated by the association of re...

    Authors: Israa Hussein Hamzah, Farha A. Ali Shafi, Sahar A. H. Al Sharqi and Suaad Almas Brakhas

    Citation: Clinical and Molecular Allergy 2019 17:4

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  9. Content type: Case Report

    Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently presents with dysfunction or loss of the sense of smell, resulting in a significant impairment in quality of life. The medical treatments currently ...

    Authors: Carlo Cavaliere, Cristoforo Incorvaia, Franco Frati, Daniela Messineo, Mario Ciotti, Antonio Greco, Marco de Vincentiis and Simonetta Masieri

    Citation: Clinical and Molecular Allergy 2019 17:3

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  10. Content type: Research

    A growing use of complementary alternative medicine (CAM) has been found in Europe as well in Italy for chronic diseases, including the allergic rhinitis. The study aims at investigating the prevalence and the...

    Authors: G. Bonizzoni, M. Caminati, E. Ridolo, M. Landi, M. T. Ventura, C. Lombardi, G. Senna, M. Crivellaro and F. Gani

    Citation: Clinical and Molecular Allergy 2019 17:2

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  11. Content type: Research

    Proton pump inhibitors (PPIs) are drugs capable of blocking the gastric pump H,K-ATPase in order to inhibit gastric acid secretion. Omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole belong t...

    Authors: Marco Casciaro, Michele Navarra, Giuseppina Inferrera, Marta Liotta, Sebastiano Gangemi and Paola Lucia Minciullo

    Citation: Clinical and Molecular Allergy 2019 17:1

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  12. Content type: Research

    According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma.

    Authors: Federica Novelli, Elena Bacci, Manuela Latorre, Veronica Seccia, Maria Laura Bartoli, Silvana Cianchetti, Federico Lorenzo Dente, Antonella Di Franco, Alessandro Celi and Pierluigi Paggiaro

    Citation: Clinical and Molecular Allergy 2018 16:25

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  13. Content type: Review

    Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized.

    Authors: Gino A. Vena, Nicoletta Cassano, E. Di Leo, G. F. Calogiuri and Eustachio Nettis

    Citation: Clinical and Molecular Allergy 2018 16:24

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  14. Content type: Research

    Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggri...

    Authors: Zafar Rasheed, Khaled Zedan, Ghada Bin Saif, Ragaa H. Salama, Tarek Salem, Ahmed A. Ahmed, Alaa Abd El-Moniem, Maha Elkholy, Ahmad A. Al Robaee and Abdullateef A. Alzolibani

    Citation: Clinical and Molecular Allergy 2018 16:23

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  15. Content type: Case Report

    Brentuximab vedotin (BV) is an antibody–drug conjugate formed by an anti-CD30 chimeric IgG1 conjugated with monomethyl-auristatin-E. BV targets the CD30+ cells, which characterize Hodgkin lymphoma as well as anap...

    Authors: Attilio Di Girolamo, Marcello Albanesi, Alessandro Sinisi, Eustachio Nettis, Danilo Di Bona, Maria Filomena Caiaffa and Luigi Macchia

    Citation: Clinical and Molecular Allergy 2018 16:22

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  16. Content type: Case Report

    Kounis syndrome (KS) has been described as the coincidental occurrence of acute coronary syndromes during an allergic reaction with cardiac anaphylaxis. It is caused by inflammatory mediators released after ex...

    Authors: Luisa Ricciardi, Fabiana Furci, Marco Casciaro, Eleonora Di Salvo, Mariateresa Cristani, Valeria Tigano, Paola Lucia Minciullo and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:21

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  17. Content type: Review

    According to the World Health Organization, air pollution is closely associated with climate change and, in particular, with global warming. In addition to melting of ice and snow, rising sea level, and floodi...

    Authors: Vincenzo Patella, Giovanni Florio, Diomira Magliacane, Ada Giuliano, Maria Angiola Crivellaro, Daniela Di Bartolomeo, Arturo Genovese, Mario Palmieri, Amedeo Postiglione, Erminia Ridolo, Cristina Scaletti, Maria Teresa Ventura and Anna Zollo

    Citation: Clinical and Molecular Allergy 2018 16:20

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  18. Content type: Case Report

    New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our stud...

    Authors: Stefania Isola, Fabiana Furci and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:19

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  19. Content type: Case Report

    Severe aortic valve stenosis is one of the most common cause of mortality in adult patients affected with metabolic syndrome, a condition associated with an active inflammatory process involving also mast cell...

    Authors: Laura M. Losappio, Corrado Mirone, Michel Chevallard, Laura Farioli, Fabrizio De Luca and Elide A. Pastorello

    Citation: Clinical and Molecular Allergy 2018 16:17

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  20. Content type: Research

    Sublingual immunotherapy (SLIT) is effective, tolerable, and convenient for many allergic patients. Still, real-world evidence is scarce and the aim of this study is to assess the patient reported outcome of t...

    Authors: Christer Janson, Fredrik Sundbom, Peter Arvidsson and Mary Kämpe

    Citation: Clinical and Molecular Allergy 2018 16:14

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  21. Content type: Correspondence

    Allergic asthma is an inflammatory disorder of the airways that results from inappropriate production of IgE against harmless, environmental antigens. Sequestration of free IgE using humanized IgG anti-IgE is ...

    Authors: Sonali J. Bracken, Alexander J. Adami, Ektor Rafti, Craig M. Schramm and Adam P. Matson

    Citation: Clinical and Molecular Allergy 2018 16:13

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  22. Content type: Research

    Based on meta-analyses results, it is currently acknowledged that there is an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) undergoing inhaled corticosteroids (ICS) ...

    Authors: Erminia Ridolo, Cristoforo Incorvaia, Irene Martignago, Laura Pessina, Fulvio Lauretani, Luciano Loperfido, Gian Galeazzo Riario-Sforza, Annalisa Broglia, Bruna L. Gritti and Lorenzo Panella

    Citation: Clinical and Molecular Allergy 2018 16:12

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  23. Content type: Review

    Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes,...

    Authors: Marco Casciaro, Eleonora Di Salvo, Teresa Brizzi, Carmelo Rodolico and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:11

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  24. Content type: Research

    Hymenoptera sting reactions are among life-threatening causes of allergy. Several epidemiology studies have assessed the risk of these kind of reactions, among the general population, around 3% of adults. This...

    Authors: Luisa Ricciardi, Francesco Papia, Giuseppe Cataldo, Mario Giorgianni, Giovanna Spatari and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2018 16:8

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  25. Content type: Case report

    Parasite infections stimulate total and specific IgE production that, in the case of Toxocara canis infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar sympt...

    Authors: Rosanna Qualizza, Laura M Losappio and Fabiana Furci

    Citation: Clinical and Molecular Allergy 2018 16:10

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  26. Content type: Research

    The use of drugs in the elderly is very extensive because of the frequent occurrence of chronic diseases. Adverse drug reactions (ADRs) commonly occur in geriatric patients receiving multiple therapeutic regim...

    Authors: Maria Teresa Ventura, Elisa Boni, Rosa Cecere, Rosalba Buquicchio, Gian Franco Calogiuri, Irene Martignago, Cristoforo Incorvaia and Erminia Ridolo

    Citation: Clinical and Molecular Allergy 2018 16:7

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  27. Content type: Review

    Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been includ...

    Authors: Boaz Palterer, Gianfranco Vitiello, Alessia Carraresi, Maria Grazia Giudizi, Daniele Cammelli and Paola Parronchi

    Citation: Clinical and Molecular Allergy 2018 16:5

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  28. Content type: Review

    Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the prog...

    Authors: Matteo Ferrando, Francesca Racca, Lorena Nascimento Girardi Madeira, Enrico Heffler, Giovanni Passalacqua, Francesca Puggioni, Niccolò Stomeo and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2018 16:6

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  29. Content type: Research

    Allergic Rhinitis (AR) is a high-prevalence disease. In Europe about 25% of the general population is affected, and in Italy the prevalence is estimated to be 19.8%. The Allergic Rhinitis and its Impact on Ast...

    Authors: Federica Gani, Carlo Lombardi, Laura Barrocu, Massimo Landi, Erminia Ridolo, Massimo Bugiani, Giovanni Rolla, Gianenrico Senna and Giovanni Passalacqua

    Citation: Clinical and Molecular Allergy 2018 16:4

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  30. Content type: Research

    The query “are there animals at home?” is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studi...

    Authors: G. Liccardi, L. Calzetta, G. Baldi, A. Berra, L. Billeri, M. Caminati, P. Capano, E. Carpentieri, A. Ciccarelli, M. A. Crivellaro, M. Cutajar, M. D’Amato, I. Folletti, F. Gani, D. Gargano, D. Giannattasio…

    Citation: Clinical and Molecular Allergy 2018 16:3

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  31. Content type: Research

    Hymenoptera venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account f...

    Authors: Marcello Albanesi, Andrea Nico, Alessandro Sinisi, Lucia Giliberti, Maria Pia Rossi, Margherita Rossini, Georgios Kourtis, Anna Simona Rucco, Filomena Loconte, Loredana Muolo, Marco Zurlo, Danilo Di Bona, Maria Filomena Caiaffa and Luigi Macchia

    Citation: Clinical and Molecular Allergy 2018 16:2

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  32. Content type: Review

    The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention...

    Authors: Roberto Paganelli, Claudia Petrarca and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2018 16:1

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  33. Content type: Review

    The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescen...

    Authors: Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi and Rosalba Buquicchio

    Citation: Clinical and Molecular Allergy 2017 15:21

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  34. Content type: Research

    Allergic diseases are on the rise in many parts of the world, including the Asia–Pacific (APAC) region. Second-generation antihistamines are the first-line treatment option in the management of allergic rhinit...

    Authors: Marysia Tiongco Recto, Ma. Teresita Gabriel, Kanokvalai Kulthanan, Pongsakorn Tantilipikorn, Derrick Chen-Wee Aw, Tak Hong Lee, Ch’ng Chin Chwen, Somasundran Mutusamy, Nguyen Trong Hao, Vo Thanh Quang and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2017 15:19

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  35. Content type: Research

    IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The...

    Authors: Jenny van Odijk, Sigrid Sjölander, Peter Brostedt, Magnus P. Borres and Hillevi Englund

    Citation: Clinical and Molecular Allergy 2017 15:18

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  36. Content type: Review

    Asthma, allergic rhinitis (AR) and atopic dermatitis are very common in young people, but in the latest decades it was increasingly recognized that also individuals of higher ages, including the population ove...

    Authors: Erminia Ridolo, Anti Rogkakou, Maria Teresa Ventura, Irene Martignago, Cristoforo Incorvaia, Gabriele Di Lorenzo and Giovanni Passalacqua

    Citation: Clinical and Molecular Allergy 2017 15:17

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  37. Content type: Review

    Anticonvulsant hypersensitivity syndrome represents a rare but potentially fatal kind of adverse drug reaction. This clinical picture often hampers the flexibility with which alternative anticonvulsants or eve...

    Authors: Fabrizio De Luca, Laura Michelina Losappio, Corrado Mirone, Jan Walter Schroeder, Antonella Citterio, Maria Gloria Aversano, Joseph Scibilia and Elide Anna Pastorello

    Citation: Clinical and Molecular Allergy 2017 15:16

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  38. Content type: Research

    Sublingual immunotherapy (SLIT) is a feasible option to classical subcutaneous immunotherapy to treat respiratory allergy and is increasingly prescribed in Europe. However, the lack of reimbursement may limit ...

    Authors: Ilaria Massaro, Oliviero Rossi, Cristoforo Incorvaia and Carlo Lombardi

    Citation: Clinical and Molecular Allergy 2017 15:15

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  39. Content type: Case Report

    Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity react...

    Authors: Malik Ghannam, Shaden Mansour, Aya Nabulsi and Qusay Abdoh

    Citation: Clinical and Molecular Allergy 2017 15:14

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  40. Content type: Review

    Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characte...

    Authors: Egidio Imbalzano, Sebastiano Quartuccio, Eleonora Di Salvo, Teresa Crea, Marco Casciaro and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2017 15:12

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  41. Content type: Research

    Early recognition of inflammatory markers and their relation to asthma, adverse drug reactions, allergic rhinitis, atopic dermatitis and other allergic diseases is an important goal in allergy. The vast majori...

    Authors: Gennaro Tartarisco, Alessandro Tonacci, Paola Lucia Minciullo, Lucia Billeci, Giovanni Pioggia, Cristoforo Incorvaia and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2017 15:10

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  42. Content type: Commentary

    Even if severe asthma (SA) accounts for 5–10% of all cases of the disease, it is currently a crucial unmet need, owing its difficult clinical management and its high social costs. For this reason several netwo...

    Authors: G. Senna, M. Guerriero, P. L. Paggiaro, F. Blasi, M. Caminati, E. Heffler, M. Latorre and G. W. Canonica

    Citation: Clinical and Molecular Allergy 2017 15:9

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The official journal of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC)

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