- Open Access
Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life
Clinical and Molecular Allergy volume 20, Article number: 6 (2022)
Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies. Aim of the study was to evaluate the efficacy and safety of dupilumab in adult patients with CRSwNP stratified by common overlapping comorbid conditions.
We performed a multicenter, observational, prospective study enrolling adult patients with severe CRSwNP who had started dupilumab treatment in the context of standard care from January 2021 to October 2021. Data were collected from twentynine Italian secondary care centers for allergy and clinical immunology, all of which were part of the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). A number of efficacy parameters were used. Patient data were compared using the Wilcoxon test for paired data. All statistical analyses were performed with SPSS version 20 (IBM, Armonk, NY, USA).
In total, 82 patients with nasal polyposis were identified. A significant improvement was detected for all the applied efficacy parameters, i.e. 22-item Sino-Nasal Outcome Test (SNOT-22) and bilateral endoscopic nasal polyp score (NPS) scores for CRSwNP, Rhinitis Control Scoring System (RCSS) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores for allergic perennial rhinitis, Forced Expiratory Volume in the 1st second (FEV1) and Asthma Quality of Life Questionnaire (AQLQ) scores for asthma, Eczema Area and Severity Index (EASI) and Dermatology Life Quality Index (DLQI) scores for AD. A non-significant improvement was also obtained in the Urticaria Activity Score over 7 days (UAS7) for chronic spontaneous urticaria. Treatment with dupilumab was well tolerated.
These data suggest that dupilumab treatment in patients suffering from CRSwNP and associated comorbidities may be suitable. Such outcome, although confirmation by trials is warranted, suggests the possibility to treat different disorders with a single therapy, with favorable effects especially under the cost-effectiveness aspect.
Although the term biological also encompasses therapies that have been in use for decades, such as vaccines, blood and its component, cells, allergens, genes, a modern classification defines biologics as the product obtained from living organisms or containing components of living organisms. Another key feature is the protein content of biologics that control the action of other proteins and cellular processes, genes encoding for vital proteins, or cells that produce substances suppressing or activating components of the immune system . The number of products derived from human, animal, or microorganisms by using biotechnology is continuously expanding. As far as upper airways diseases are concerned, chronic rhinosinusitis with nasal polyps (CRSwNP) has long been considered to be closely related to aspirin sensitization , but today the crucial role of cytokines in the pathogenesis of this disease is also acknowledged, notably Th2 cytokines due to their role in eosinophils recruitment and maintenance of inflammatory response .
In the latest years, a number of monoclonal antibodies (including mepolizumab, reslizumab, and benralizumab) were approved to treat, in addition to severe asthma, other disorders linked to type 2 immune responses including CRSwNP . Dupilumab is a IgG4 monoclonal antibody which targets the IL-4 receptor alpha chain (IL-4Rα), thus inhibiting the biological effects of the cytokines IL-4 and IL-13, that are crucial for the Th2 response . Dupilumab was demonstrated by meta-analyses to be effective and safe also for the treatment of adult patients with moderate-to-severe atopic dermatitis (AD) not adequately controlled with standard treatment  as well as for severe CRSwNP  and uncontrolled asthma .
The objective of this study is intended to describe effectiveness of dupilumab in the real-world setting and in the management of patients with CRSwNP stratified by common overlapping comorbid conditions.
Materials and methods
Study design and patients
We performed a multicenter, observational, prospective study enrolling adult patients with severe CRSwNP who had started dupilumab treatment in the context of standard care from January 2021 to October 2021. Data were collected from twenty-nine Italian secondary care centers for allergy and clinical immunology, all of which were part of the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). To participate in the study, each center was asked to provide data from patients ≥ 18 years of age with CRSwNP who had undergone previous treatment with systemic corticosteroids (SCS), had a contraindication or intolerance to SCS in the previous 2 years, or had a history of sinonasal surgery.
At screening, patients must have NPS of at least 1 (maximum 8), and exhibit at least two of the following symptoms: nasal congestion or obstruction and either loss of smell or nasal discharge (anterior or posterior). Patients were required to have not undergone previous nasal polyp removal surgery within 6 months before screening. Use of monoclonal antibodies, immunosuppressants, or anti-IgE therapy was not allowed from 2 months before treatment until the end of the study. Patients who met the inclusion criteria underwent complete ear, nose, and throat examination.
All procedures complied with the Helsinki Declaration of 1964, revised in 2013. The study protocol was approved by the ethical committee of Naples University Hospital, Italy. Informed consent was obtained from all patients who agreed to participate to this study.
At baseline, all patients received a loading dose of dupilumab 300 mg subcutaneously administered by a clinician, followed by dupilumab 300 mg every other week for 16 weeks. A wash-out period was not required. Patients were asked to discontinue systemic immune-suppressants before starting dupilumab treatment. Rescue treatment could be provided to patients at the investigator’s discretion. Throughout the study period, patients were required to maintain their pre-treatment therapy for the management of CRSwNP (i.e., saline nasal lavage, systemic antibiotics) and other comorbidities.
Patients were assessed for medical history, demographics, comorbid diseases (ie, allergic rhino-conjunctivitis, asthma, atopic dermatitis, chronic spontaneous urticaria), concomitant medications or procedures, adverse events, and efficacy outcomes at baseline; and efficacy every 4 weeks (weeks 4–16).
Drug safety was evaluated by recording and monitoring the frequency and severity of treatment-emergent and serious adverse events.
Procedures, outcomes and statistical analysis
In CRSwNP patients, outcome measures at baseline and after 4 months included endoscopic NPS as assessed by endoscopy for each nostril separately and graded by polyp size (range: 0 to 4); 22-item Sino-Nasal Outcome Test (SNOT-22) (range: 0–110) which assesses the quality of life and the symptoms of sinusitis; patient reported total symptom score (TSS) (range 0–9), in which patients recorded severity of symptoms (nasal congestion [NC], loss of smell [LoS], and anterior/posterior rhinorrhea) in a daily symptom e-diary using a 4-point scale (0 = no symptoms; 1 = mild symptoms; 2 = moderate symptoms; and 3 = severe symptoms) and calculated as a composite severity score consisting of the sum of the NC (range 0–3), LoS (range 0–3), and rhinorrhea (average of anterior/posterior scores for nasal discharge) (range 0–3) symptom scores. Rhinosinusitis disease and smell capacity were also documented according to “the visual analog method”. The intensity of every symptom was assessed on the Visual Analogue Scale (VAS) from 0 to 10.
The comorbidities were evaluated using: Rhinitis Control Scoring System (RCSS) (range: 10–50), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) (range: 0–6), Spirometry, Asthma Control Test (ACT) (range: 0–25), Asthma Quality of Life Questionnaire (standardized version) (AQLQ[S]) (range: 0–7), Eczema Area and Severity Index (EASI) score (range: 0–72); peak score on the Numerical Rating Scale (NRS) for pruritus (range: 0–10), peak score on the NRS for sleep (range: 0–10), Dermatology Life Quality Index (DLQI) (range: 0–28), Urticaria Activity Score over 7 days (UAS7) (range 0–42).
Within-patient improvement in SNOT-22, RQLQ, ACT and AQLQ(S) scores of at least 8.9, 0.5, 3 or 0.5 respectively, was considered clinically meaningful, as defined by the questionnaire developers [9,10,11,12]. Controlled asthma was defined as asthma with a composite ACT score of more than 19, and the absence of exacerbations during the 16-week treatment period .
Skin prick tests using commonly available foods and inhalants were performed according to the established guidelines on all patients. Clinical evaluation also included total serum IgE levels and the blood eosinophil count. Total serum IgE levels were measured using immunofluorometric assay and expressed in KUA/L, according to the manufacturer’s instructions. Total IgE normal values were considered to be < 100 KU/L. An eosinophil count < 500/mm3 was considered normal.
Patient data were compared using the Wilcoxon test for paired data. All statistical analyses were performed with SPSS version 20 (IBM, Armonk, NY, USA). The threshold for statistical significance was set at P < 0.01.
In total, 82 patients with nasal polyposis were identified. Eight patients were excluded in the analysis due to the following reasons: three patients stopped treatment before 16 weeks, but none was due to treatment failure (2 stopped due to gastrointestinal symptoms unrelated to dupilumab administration, 1 due to personal reasons), and the remaining 5 had missing baseline data. Seventy-four patients with CRSwNP who received at least one dose of dupilumab at the study centres were included in the study. Baseline demographics and characteristics are shown in Table 1.
In our cohort, 32 patients (43.2%) were female and the median ± interquartile range (IQR) for patient age was 46.5 ± 19.8 years. The median ± IQR body-mass index was 25.5 ± 6.1 kg/m2. The median ± IQR endoscopic NPS score was 5.0 ± 2.0 while SNOT-22 score was 54.5 ± 28.8. Before enrolment, 50 patients (67.6%) had received systemic glucocorticoids. Fifty patients (67.6%) had positive prick test results. Comorbid type 2/Th2 immune diseases were common.
Chronic rhinosinusitis with nasal polyps
The endoscopic NPS and total SNOT-22 score significantly diminished from baseline to week 16 (median ± IQR percentage change = − 50.0 ± 33.3 and median ± IQR percentage change = -54.5 ± 41.6, respectively, p < 0.001) (Table 2), 69 patients (93.2%) achieving at least a 1-point improvement in NPS at week 16. Sixty-eight patients (91.9%) had a clinically meaningful improvement in SNOT-22 score (at least 8.9 points). Improvements in NPS and SNOT-22 occurred as early as the first assessment timepoint after the start of dupilumab treatment (within the first 4 to 8 weeks), with continuous improvement evident up to the end of treatment in the study.
The median percentage change ± IQR in patients reporting the TSS (− 62.5 ± 30), the median percentage change ± IQR in NC score (− 66.7 ± 16.7), the median ± IQR percentage change in LoS score (− 66.7 ± 66.7) and the median ± IQR percentage change in anterior/posterior rhinorrhea score (− 66.7 ± 58.3) each showed a significant decrease from baseline to week 16 (p < 0.001). Patient scores on the rhinosinusitis disease severity and smell capacity assessed with VAS were 9 and 9, before treatment was commenced. After 16 weeks of treatment, the scores were 2 and 2, respectively (p < 0.001).
The percentage of patients who were receiving daily oral corticosteroids (OCS) significantly decreased from 67.6% to 16.2% (p < 0.001). The median ± IQR prednisone equivalent dose was 6.9 ± 9.3 mg at baseline (in 50 patients) and 4.0 ± 3.7 mg at week 16 (in 12 patients).
The median ± IQR total IgE plasma level, measured in 59 patients, decreased at week 16 with a median ± IQR of 210.0 ± 372.0 compared to 451.5 ± 286.8 before dupilumab initiation (p < 0.001).
Concerning the median ± IQR total blood eosinophil count, measured in 63 patients, no significant differences from baseline were found by week 16 (550.0 cell/mm3 ± 500.0 vs 481.0 cell/mm3 ± 500.0; p > 0.05) (Table 2).
In our patients, clinical history, ENT and skin prick tests were used for the diagnosis of allergic rhinitis. Thirty-one (41.9%) patients were identified as having perennial allergic rhinitis due to allergens that are present year-round (14 women; 17 men) (Table 2). The median ± IQR percentage change of RCSS global total score and RQLQ score from baseline to week 16 was − 40.0 ± 30.7 and − 41.5 ± 31.5, respectively (p < 0.001). The minimal clinically meaningful difference of 0.5 points or more in RQLQ score was observed in 28 of 31 patients (90.3%).
The diagnosis and assessment of severity of asthma was made in 46 patients (20 women; 26 men) according to the Global Initiative for Asthma (GINA)  (Table2). All patients in this subgroup had received asthma medications, primarily inhaled corticosteroids and long-acting β-agonists in the preceding year.
With regard to lung function, prebronchodilator Forced Expiratory Volume in the 1st second (FEV1) had improved from a baseline median of 2.7 ± 0.8 L to 2.8 ± 0.9 L after 16 weeks of treatment with dupilumab (p < 0.001), while the median ± IQR FEV1 (per cent of predicted value before bronchodilation) was 90.5 ± 15.3 at baseline and 96.5 ± 11.5 at week 16 (p < 0.001). At the end of the treatment period, 24 patients improved to 0.1 L or more and 9 patients to more than 0.2 L. Disease control was evaluated using ACT. When compared to the baseline measurement of 18.0 ± 6.8, ACT scores had significantly increased to 24.0 ± 5.0 after 16 weeks (p < 0.001).
Thirty-one out of 46 patients (67.4%) achieved the minimally clinically meaningful difference (at least three points) at the 16-week stage. At baseline, 19 out of 46 patients (41.3%) had conditions that were considered as being under control; 40 out of 46 patients (87%) had controlled asthma at week 16. After 16 weeks of therapy with dupilumab, AQLQ scores had significantly increased from a baseline value of 4.3 ± 2.8 to 6.0 ± 1.3 (p < 0.001). Twenty-nine out of 46 patients (63%) achieved the minimally clinically meaningful difference (at least 0.5 points) in the AQLQ. At baseline, a total of 18 patients (39.1%) had developed at least one severe exacerbation requiring the initiation of SCS during the 4-months period preceding the dupilumab treatment. None of the 46 patients developed at least one severe exacerbation during the treatment period (p < 0.001).
As to AD, dupilumab significantly improved measures of clinical efficacy and quality of life (QoL) at week 16. The median ± IQR EASI score significantly improved from 34.2 ± 20.0 at baseline to 4.3 ± 1.4 at 16 weeks (p < 0.01). The median ± IQR peak score on NRS for pruritus and for sleep significantly decreased from 8.5 ± 1.0 at baseline to 3.0 ± 1.0 at 16 weeks (p < 0.01) and from 8.0 ± 0.8 at baseline to 1.5 ± 2.5 at 16 weeks (p < 0.01), respectively. Finally, the median ± IQR DLQI score significantly decreased from 24.0 ± 12.5 at baseline to 4.0 ± 1.8 at 16 weeks (p < 0.01) (see Table 3).
At 16 weeks, 8 out of 10 patients (80%) had achieved ≥ 75% improvement from baseline as measured by EASI score (EASI-75).
Chronic spontaneous urticaria (CSU) is defined as the spontaneous occurrence of wheals and/or angioedema for six or more weeks [16, 17]. Three patients with CSU who were being treated with dupilumab had a baseline median ± IQR UAS-7 score of 12.0 ± 4.0 points, which.
became lower after 16 weeks (0 ± 5.0; p > 0.05). At the end of the 16-week study, 2 out of 3 patients (66.7%) reported a complete response to dupilumab treatment (UAS7 score = 0).
Overall, instances of adverse events (AEs) were low and did not lead to treatment discontinuation. In our cohort, 33.8% of patients overall reported AEs during treatment. Asthenia, arthralgia and de novo conjunctivitis were the most common AEs (Table 4). No treatment-emergent AEs were reported during the study.
This is the first observational study that demonstrates the effectiveness of dupilumab in real-life conditions in patients with perennial allergic rhinitis (PAR) and/or asthma and/or AD and/or CSU associated with CRSwNP.
Since the first randomized, double blind-placebo controlled trial in adults with moderate-to-severe atopic dermatitis in 2014, dupilumab has demonstrated its efficacy and safety also in other diseases such as severe uncontrolled asthma  and CRSwNP . Globally, the evidence for efficacy is strong, as proved by a number of meta-analyses [20,21,22]. Acknowledging that the strict rules of controlled trials do not allow inclusion of the majority of patients seen by doctors in current practice, the performance of real-life studies is spreading. A systematic review and meta-analysis including 22 studies in real life encompassing 3303 atopic dermatitis patients confirmed the efficacy of dupilumab also in common practice . Meta-analyses are also available concerning the safety of treatment. Ou et al. in a meta-analysis including 5 randomized controlled trials found that dupilumab slightly increased the risk of headache, and moderately increased the risk of injection-site reaction and conjunctivitis, but had little effect on other infections in adults with moderate-to-severe atopic dermatitis . In a meta-analysis including 8 randomized controlled trials no side effect was reported, while a significantly decrease in the risk for skin infections and eczema herpeticum was observed . In the metanalysis by Han and co-workers cited above also safety was evaluated, with a reassuring overall picture . A pooled analysis showed that the incidence of side effects was 55.5% in patients receiving dupilumab and 45% in patients receiving placebo, this difference being not significant . The other disorder with clear evidence of efficacy of dupilumab is CRSwNP, which was evaluated in a Cochrane Database Systematic Review including 8 randomized controlled trials encompassing 986 adult patients . The results showed that dupilumab improves disease-specific quality of life compared to placebo and reduces the extent of the disease as measured on a computerised tomography scan. The risk of serious adverse events was not increased in actively treated patients. The same authors performed a new Cochrane Systematic Review one year later, adding two trials and assessing also others biologics. The outcome confirmed the previous observations and suggested that treatment with dupilumab probably also results in a reduction in disease severity and in the number of serious adverse events .
The peculiarity of our multicenter, observational, prospective study consists in having also evaluated the effects of dupilumab on other common disorders such as PAR and CSU, whose evidence of effectiveness in a real-world setting is far less studied compared to CRSwNP , atopic dermatitis  and severe asthma .
In a prospective observational study , Yakamoto et al. and colleagues reported a favorable response to dupilumab treatment in 21 patients with severe comorbid PAR. In this group, significant improvements were observed in subjective symptoms, QoL scores, face scale and findings of nasal cavity after 12 months of treatment.
Another prospective study  reported that dupilumab treatment in 31 patients with comorbid PAR was associated with significant improvements in several patient-reported outcomes, including PAR disease control as measured by an RCSS global score and PAR QoL as assessed by validated, disease-specific tools (RQLQ).
As for CSU, three patients with a history of primary/secondary failure to several agents used for their CSU, including standard and high dose of second-generation H1-antihistamines, omalizumab, methotrexate (only in 2 patients), cyclosporine (only in 2 patients), prednisone (only in 1 patient) and ketotifen (only in 1 patient) were treated with dupilumab (600 mg, followed by 300 mg every other week). Within a few months, these patients were free of clinical manifestations [32, 33].
To the best of our knowledge, no studies are available on the effect of dupilumab in patients with concomitant CRSwNP, PAR, asthma, AD and CSU. We performed a study on 82 patients, using a number of efficacy parameters. Significant improvement both in terms of symptoms and QoL was detected for all parameters, i.e. SNOT-22 and NPS scores for CRSwNP, RCSS and RQLQ scores for PAR, FEV1 and AQLQ scores for asthma, EASI, and DLQI scores for AD. These results validate the key role that IL-4 and IL-13 play in the induction and perpetuation of type 2 immune responses implicated in CRSwNP and atopic comorbidities . Treatment with dupilumab was well tolerated in the present study. The most common AEs were asthenia and arthralgia, which were not related to dupilumab treatment. Limitations of this study include the short follow‐up and lack of control patients. These data suggest that dupilumab treatment in patients suffering from CRSwNP and associated comorbidities may be suitable, especially under the pharmaco-economic aspect.
A recent study  evaluated the long-term treatment costs and benefits of dupilumab for the treatment of moderate-to-severe adult AD patients over the course of their lifetime. The results suggested that, based on the increase in quality-adjusted life years (QALYs) achieved with dupilumab relative to supportive care (SC), dupilumab is cost-effective compared with SC across a range of annual maintenance prices in this US adult patient population. Up to now no studies have been carried out on the economic value of dupilumab in the treatment of adult patients with CRSwNP , but considering the cost-effectiveness demonstrated for AD treatment, it is reasonable to hypothesize that a single treatment in patients with different diseases could be further profitable. In any case, biologics effectiveness on multiple diseases will modify the restriction of use due to the high costs that had been raised for single diseases, even in the presence of risk of death, as in severe uncontrolled asthma .
However, the results we observed must be confirmed by studies on larger patient populations and, in particular, for cost-effectiveness aspect, by specific analyses.
Availability of data and materials
All data generated or analysed during this study are included in this published article.
Asthma control test
Asthma Quality of Life Questionnaire
Chronic rhinosinusitis with nasal polyps
Chronic spontaneous urticaria
Dermatology Life Quality Index
Eczema Area and Severity Index
Forced Expiratory Volume in the 1st second
Global Initiative for Asthma
IL-4 receptor alpha chain
Loss of smell
Numerical Rating Scale
Perennial allergic rhinitis
Quality-adjusted life years
Rhinitis Control Scoring System
Rhinoconjunctivitis Quality of Life Questionnaire
Italian Society of Allergy, Asthma and Clinical Immunology
22-Item Sino-Nasal Outcome Test
Patient reported total symptom score
Urticaria Activity Score over 7 days
Visual Analogue Scale
Andrews L, Ralston S, Blomme E, Barnhart K. A snapshot of biologic drug development: challenges and opportunities. Hum Exp Toxicol. 2015;34(12):1279.
Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl. 2012;23:1–299.
Carsuzaa F, Béquignon E, Dufour X, De Bonnecaze G, Lecron JC, Favot L. Cytokine signature and involvement in chronic rhinosinusitis with nasal polyps. Int J Mol Sci. 2021;23(1):417.
Chong LY, Piromchai P, Sharp S, Snidvongs K, Webster KE, Philpottet C, et al. Biologics for chronic rhinosinusitis. Cochrane Database Syst Rev. 2021;3(3):CD013513.
Harb H, Chatila TA. Mechanisms of dupilumab. Clin Exp Allergy. 2020;50(1):5–14.
Wang FP, Tang XJ, Wei CQ, Xu LR, Mao H, Luo FM. Dupilumab treatment in moderate-to-severe atopic dermatitis: a systematic review and meta-analysis. J Dermatol Sci. 2018;90(2):190–8.
Zayed Y, Kheiri B, Banifadel M, Hicks M, Aburahma A, Hamid K, et al. Dupilumab safety and efficacy in uncontrolled asthma: a systematic review and meta-analysis of randomized clinical trials. J Asthma. 2019;56(10):1110–9.
Hopkins C, Gillett S, Slack R, Lund VJ, Browne JP. Psychometric validity of the 22-item sinonasal outcome test. Clin Otolaryngol. 2009;34:447–54.
Schatz M, Kosinski M, Yarlas A, Hanlon J, Watson ME, Jhingran P. The minimally important difference of the asthma control test. J Allergy Clin Immunol. 2009;124:719–23.
Juniper EF, O’Byrne PM, Guyatt GH, Ferrie PJ, King DR. Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999;14:902–7.
Juniper EF, Svensson K, Mork AC, Stahl E. Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. Respir Med. 2005;99:553–8.
Juniper EF, Guyatt GH, Willan A, Griffith LE. Determining a minimal important change in a disease-specific quality of life questionnaire. J Clin Epidemiol. 1994;47:81–7.
Initiative for Asthma G. Global Strategy for Asthma Management and Prevention; 2016. www. ginasthma.org.
Hanifin JM, Cooper KD, Ho VC, Kang S, Krafchik BR, Margolis DJ, et al. Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association ‘“Administrative Regulations for Evidence-Based Clinical Practice Guidelines.”’ J Am Acad Dermatol. 2004;50:391–404.
Nettis E, Ortoncelli M, Pellacani G, Foti C, Di Leo E, Patruno C, et al. A Multicenter study on the prevalence of clinical patterns and clinical phenotypes in adult atopic dermatitis. J Investig Allergol Clin Immunol. 2020;30(6):448–50.
Marzano AV, Genovese G, Casazza G, Fierro MT, Dapavo P, Crimi N, et al. Predictors of response to omalizumab and relapse in chronic spontaneous urticaria: a study of 470 patients. J Eur Acad Dermatol Venereol. 2019;33(5):918–24.
Nettis E, Dambra P, Loria MP, Cenci L, Vena GA, Ferrannini A, et al. Mast-cell phenotype in urticaria. Allergy. 2001;56(9):915.
Xiong XF, Zhu M, Wu HX, Fan LL, Cheng DY. Efficacy and safety of dupilumab for the treatment of uncontrolled asthma: a meta-analysis of randomized clinical trials. Respir Res. 2019;20(1):108.
Klimek L, Chaker A, Deitmer T, Plontke SK, Wollenberg B, Bousquet J, et al. Dupilumab has an additional benefit in treatment of chronic rhinosinusitis with nasal polyps. HNO. 2021;69(11):868–77.
Han Y, Chen Y, Liu X, Zhang J, Su H, Wen H, et al. Efficacy and safety of dupilumab for the treatment of adult atopic dermatitis: a meta-analysis of randomized clinical trials. J Allergy Clin Immunol. 2017;140(3):888–91.
Snast I, Reiter O, Hodak E, Friedland R, Mimouni D, Leshem YA. Are biologics efficacious in atopic dermatitis? A systematic review and meta-analysis. Am J Clin Dermatol. 2018;19(2):145–65.
Silverberg JI, Thyssen JP, Fahrbach K, Mickle K, Cappelleri JC, Romero W, et al. Comparative efficacy and safety of systemic therapies used in moderate-to-severe atopic dermatitis: a systematic literature review and network meta-analysis. J Eur Acad Dermatol Venereol. 2021;35(9):1797–810.
Halling AS, Loft N, Silverberg JI, Guttman-Yassky E, Thyssen JP. Real-world evidence of dupilumab efficacy and risk of adverse events: a systematic review and meta-analysis. J Am Acad Dermatol. 2021;84(1):139–47.
Ou Z, Chen C, Chen A, Yang Y, Zou W. Adverse events of dupilumab in adults with moderate-to-severe atopic dermatitis: a meta-analysis. Int Immunopharmacol. 2018;54:303–10.
Fleming P, Drucker AM. Risk of infection in patients with atopic dermatitis treated with dupilumab: a meta-analysis of randomized controlled trials. J Am Acad Dermatol. 2018;19:62–9.
Chen X, Liu M, Wu S, Huang Z, Li X, Lai X, et al. Treatment-emergent adverse events in dupilumab-treated patients with allergic diseases: a meta-analysis. Allergy. 2021;76(2):593.
Nettis E, Patella V, Brancaccio R, Detoraki C, Di Leo E, Incorvaia C, et al. Efficacy of dupilumab in concomitant atopic dermatitis and chronic rhinosinusitis with nasal polyps: a preliminary study. Allergy Asthma Immunol Res. 2021;13(2):347–9.
Patruno C, Napolitano M, Argenziano G, Peris K, Ortoncelli M, Girolomoni G, Dupilumab for Atopic Dermatitis of the Elderly study group, et al. Dupilumab therapy of atopic dermatitis of the elderly: a multicentre, real-life study. J Eur Acad Dermatol Venereol. 2021;35(4):958–64.
Dupin C, Belhadi D, Guilleminault L, Gamez AS, Berger P, De Blay F, et al. Effectiveness and safety of dupilumab for the treatment of severe asthma in a real-life French multi-centre adult cohort. Clin Exp Allergy. 2020;50(7):789–98.
Yamamoto M, Okuno M, Sasaki T, Fujimoto R, Kataoka Y, Kawashima K. Effects of dupilumab on perennial allergic rhinitis in atopic dermatitis patients. Arerugi. 2020;69(10):979–88.
Nettis E, Patella V, Lombardo C, Detoraki A, Macchia L, Di Leo E, et al. Efficacy of dupilumab in atopic comorbidities associated with moderate-to-severe adult atopic dermatitis. Allergy. 2020;75(10):2653–61.
Errichetti E, Stinco G. Recalcitrant chronic urticaria treated with dupilumab: Report of two instances refractory to H1-antihistamines, omalizumab and cyclosporine and brief literature review. Dermatol Ther. 2021;34(2): e14821.
Lee JK, Simpson RS. Dupilumab as a novel therapy for difficult to treat chronic spontaneous urticaria. J Allergy Clin Immunol Pract. 2019;7(5):1659–2166.
Gandhi NA, Pirozzi G, Graham NMH. Commonality of the IL-4/IL-13 pathway in atopic diseases. Expert Rev Clin Immunol. 2017;13(5):1–13.
Kuznik A, Bégo-Le-Bagousse G, Eckert L, Gadkari A, Simpson E, Graham CN, et al. Economic evaluation of dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults. Dermatol Ther (Heidelb). 2017;7(4):493–505.
Codispoti CD, Mahdavinia M. A call for cost-effectiveness analysis for biologic therapies in chronic rhinosinusitis with nasal polyps. Ann Allergy Asthma Immunol. 2019;123(3):232–9.
Quirce S, Phillips-Angles E, Domínguez-Ortega J, Barranco P. Biologics in the treatment of severe asthma. Allergol Immunopathol (Madr). 2017;45(Suppl 1):45–9.
Ethics approval and consent to participate
The study protocol (#75/21) was approved by the ethical committee of Naples University Hospital, Italy. Informed consent was obtained from all patients who agreed to participate to this study.
Consent for publication
PP: GSK, Novartis (fees for lectures), LeoPharma (expert board); DB: GSK, Novartis, Astra, Sanofi (speaker); MC: GSK, Sanofi (speaker); EH: Sanofi, Regeneron, Novqrtis, GSK, Astrazeneca, Circassia, Stallergenes-Greer, Nestlè Purina (speaker and advisory board), AD: Sanofi, Glaxo-Smith Kline (advisory board), SDG: AstraZeneca, GSK, Novartis, Sanofi (advisory board and speaker). EN, LB, VP, LB, EDL, MMS, MT, ER, LM, GR, RB, GS, DDB, ADP, FCB, AMD, CC, CL, LG, MDG, KJ, EN, LD, DC, GG, FG, GS, DV, FLR, GP, FP, GC, LC, MTC, MAC, SD, PDB, LDP, EF, SG, MSLB, FL, AM, MRY, PLM, SP, OR, LS, MS, AV, AV, YB, CI, GWC have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Nettis, E., Brussino, L., Patella, V. et al. Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life. Clin Mol Allergy 20, 6 (2022). https://doi.org/10.1186/s12948-022-00171-2