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Table 1 Characteristics of patients included in the study (N = 74)

From: Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life

Variable

Value*

Age (y)

46.5 ± 19.8

Sex, female

32 (43.2)

BMI

25.5 ± 6.1

Nasal polyp duration (y)

8.8 ± 2.0

Nasal polyp surgery

 ≥ 1 previous surgery

61 (82.4)

 ≥ 3 previous surgeries

11 (14.9)

Time since most recent polyp surgery (y)

2.5 ± 4.9

Bilateral endoscopic NPS

5.0 ± 2.0

SNOT-22 total score

54.5 ± 28.8

Nasal congestion or obstruction score

3.0 ± 1.0

 Missing, n (%)

5 (6.8)

Loss-of-smell score

3.0 ± 1.0

 Missing, n (%)

5 (6.8)

Anterior/posterior rhinorrhea score

2.0 ± 1.0

 Missing, n (%)

5 (6.8)

Patient reported total symptom score

8.0 ± 2.0

 Missing, n (%)

5 (6.8)

Rhinosinusitis disease severity VAS

9.0 ± 2.8

 Missing, n (%)

16 (21.6)

Smell VAS

9.0 ± 2.0

 Missing, n (%)

15 (20.3)

NSAIDs intolerance n (%)

24 (32.4)

Positive skin prick test results

50 (67.6)

Allergic rhinitis

46 (62.2)

 RCSS score

24.0 ± 12.5

Missing, n (%)

3 (6.5)

 RQLQ score

3.7 ± 1.1

Missing, n (%)

3 (6.5)

Allergic conjunctivitis

24 (32.4)

Atopic keratoconjunctivitis

3 (4.0)

Asthma

46 (62.2)

 FEV1 (L)

2.7 ± 0.8

Missing, n (%)

2 (4.3)

 FEV1 (% predicted)

90.5 ± 15.3

Missing, n (%)

2 (4.3)

 ACT score

18.0 ± 6.8

 AQLQ (S) score

4.3 ± 2.80

Atopic dermatitis

10 (13.5)

 EASI score

34.2 ± 20.0

 Peak score on NRS for pruritus

8.5 ± 1.0

 Peak score on NRS for sleep

8.0 ± 0.8

 DLQI score

24.0 ± 12.5

Food allergy

6 (8.1)

 Oral allergy syndrome

1 (1.4)

 Urticaria

4 (5.4)

 Anaphylactic shock

1 (1.4)

 Eosinophilic esophagitis

0 (0)

Chronic spontaneous urticaria

3 (4.1)

 UAS7

12.0 ± 4.0

Use of systemic corticosteroids in the preceding 16 weeks

 

 Maintenance use

50 (67.6)

 Median daily dose mg

6.9 ± 9.3

IgE (KUA/L)

451.5 ± 286.8

 Missing, n (%)

17 (23)

Eosinophils (cells/mm3)

550.0 ± 500.0

 Missing, n (%)

13 (17.6)

  1. *Data are median ± IQR or n (%)
  2. ACT Asthma Control Test, AD Atopic Dermatitis, AQLQ (S) Asthma Quality of Life Questionnaire (standardized version), BMI Body Mass Index, DLQI Dermatology Life Quality Index, EASI Eczema Area and Severity Index, FEV1 Forced Expiratory Volume in 1 s, IQR Interquartile Range, NPS Nasal Polyp Score, NRS Numerical Rating Scale, NSAIDs Non-steroidal anti-inflammatory drugs, RCSS Rhinitis Control Scoring System, RQLQ Rhinitis Quality of Life Questionnaire, SNOT-22 22-item Sino-Nasal Outcome Test, UAS7 Urticaria Activity Score, VAS Visual Analog Scale