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  1. Hymenoptera venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account f...

    Authors: Marcello Albanesi, Andrea Nico, Alessandro Sinisi, Lucia Giliberti, Maria Pia Rossi, Margherita Rossini, Georgios Kourtis, Anna Simona Rucco, Filomena Loconte, Loredana Muolo, Marco Zurlo, Danilo Di Bona, Maria Filomena Caiaffa and Luigi Macchia
    Citation: Clinical and Molecular Allergy 2018 16:2
    Content type: Research Published on:

  2. The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention...

    Authors: Roberto Paganelli, Claudia Petrarca and Mario Di Gioacchino
    Citation: Clinical and Molecular Allergy 2018 16:1
    Content type: Review Published on:

  4. The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescen...

    Authors: Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi and Rosalba Buquicchio
    Citation: Clinical and Molecular Allergy 2017 15:21
    Content type: Review Published on:

  6. Allergic diseases are on the rise in many parts of the world, including the Asia–Pacific (APAC) region. Second-generation antihistamines are the first-line treatment option in the management of allergic rhinit...

    Authors: Marysia Tiongco Recto, Ma. Teresita Gabriel, Kanokvalai Kulthanan, Pongsakorn Tantilipikorn, Derrick Chen-Wee Aw, Tak Hong Lee, Ch’ng Chin Chwen, Somasundran Mutusamy, Nguyen Trong Hao, Vo Thanh Quang and Giorgio Walter Canonica
    Citation: Clinical and Molecular Allergy 2017 15:19
    Content type: Research Published on:

  7. IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The...

    Authors: Jenny van Odijk, Sigrid Sjölander, Peter Brostedt, Magnus P. Borres and Hillevi Englund
    Citation: Clinical and Molecular Allergy 2017 15:18
    Content type: Research Published on:

  8. Asthma, allergic rhinitis (AR) and atopic dermatitis are very common in young people, but in the latest decades it was increasingly recognized that also individuals of higher ages, including the population ove...

    Authors: Erminia Ridolo, Anti Rogkakou, Maria Teresa Ventura, Irene Martignago, Cristoforo Incorvaia, Gabriele Di Lorenzo and Giovanni Passalacqua
    Citation: Clinical and Molecular Allergy 2017 15:17
    Content type: Review Published on:

  9. Anticonvulsant hypersensitivity syndrome represents a rare but potentially fatal kind of adverse drug reaction. This clinical picture often hampers the flexibility with which alternative anticonvulsants or eve...

    Authors: Fabrizio De Luca, Laura Michelina Losappio, Corrado Mirone, Jan Walter Schroeder, Antonella Citterio, Maria Gloria Aversano, Joseph Scibilia and Elide Anna Pastorello
    Citation: Clinical and Molecular Allergy 2017 15:16
    Content type: Review Published on:

  10. Sublingual immunotherapy (SLIT) is a feasible option to classical subcutaneous immunotherapy to treat respiratory allergy and is increasingly prescribed in Europe. However, the lack of reimbursement may limit ...

    Authors: Ilaria Massaro, Oliviero Rossi, Cristoforo Incorvaia and Carlo Lombardi
    Citation: Clinical and Molecular Allergy 2017 15:15
    Content type: Research Published on:

  11. Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity react...

    Authors: Malik Ghannam, Shaden Mansour, Aya Nabulsi and Qusay Abdoh
    Citation: Clinical and Molecular Allergy 2017 15:14
    Content type: Case Report Published on:

  13. Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characte...

    Authors: Egidio Imbalzano, Sebastiano Quartuccio, Eleonora Di Salvo, Teresa Crea, Marco Casciaro and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2017 15:12
    Content type: Review Published on:

  15. Early recognition of inflammatory markers and their relation to asthma, adverse drug reactions, allergic rhinitis, atopic dermatitis and other allergic diseases is an important goal in allergy. The vast majori...

    Authors: Gennaro Tartarisco, Alessandro Tonacci, Paola Lucia Minciullo, Lucia Billeci, Giovanni Pioggia, Cristoforo Incorvaia and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2017 15:10
    Content type: Research Published on:

  16. Even if severe asthma (SA) accounts for 5–10% of all cases of the disease, it is currently a crucial unmet need, owing its difficult clinical management and its high social costs. For this reason several netwo...

    Authors: G. Senna, M. Guerriero, P. L. Paggiaro, F. Blasi, M. Caminati, E. Heffler, M. Latorre and G. W. Canonica
    Citation: Clinical and Molecular Allergy 2017 15:9
    Content type: Commentary Published on:

  17. Hypersensitivity to para-phenylenediamine (PPD) and related compounds induced by temporary black henna tattoos has become a serious health problem worldwide. Different patterns of sensitization with various cl...

    Authors: Gianfranco Calogiuri, Elisabetta Di Leo, Lavjay Butani, Stefano Pizzimenti, Cristoforo Incorvaia, Luigi Macchia and Eustachio Nettis
    Citation: Clinical and Molecular Allergy 2017 15:8
    Content type: Review Published on:

  18. Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sub...

    Authors: I. Djuric-Filipovic, Marco Caminati, D. Filipovic, C. Salvottini and Z. Zivkovic
    Citation: Clinical and Molecular Allergy 2017 15:7
    Content type: Research Published on:

  19. Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitiu...

    Authors: Gian Galeazzo Riario Sforza and Androula Marinou
    Citation: Clinical and Molecular Allergy 2017 15:6
    Content type: Review Published on:

  20. Allergic rhinitis has a very high burden regarding both direct and indirect costs. This makes essential in the management of AR to reduce the clinical severity of the disease and thus to lessen its costs. This...

    Authors: Carlo Lombardi, Valerie Melli, Cristoforo Incorvaia and Erminia Ridolo
    Citation: Clinical and Molecular Allergy 2017 15:5
    Content type: Review Published on:

  21. Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physicia...

    Authors: Mizuho Nagao, Magnus P. Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel and Takao Fujisawa
    Citation: Clinical and Molecular Allergy 2017 15:4
    Content type: Research Published on:

  22. Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may ...

    Authors: Fabiano Di Marco, Giuseppe Francesco Sferrazza Papa, Dejan Radovanovic and Pierachille Santus
    Citation: Clinical and Molecular Allergy 2017 15:3
    Content type: Case Report Published on:

  23. Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is pa...

    Authors: Maria Teresa Ventura, Nicola Scichilone, Roberto Paganelli, Paola Lucia Minciullo, Vincenzo Patella, Matteo Bonini, Giovanni Passalacqua, Carlo Lombardi, Livio Simioni, Erminia Ridolo, Stefano R. Del Giacco, Sebastiano Gangemi and Giorgio Walter Canonica
    Citation: Clinical and Molecular Allergy 2017 15:2
    Content type: Review Published on:

  24. Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX® is the most documented product in terms of safety and efficacy. T...

    Authors: Tomás Chivato, Pedro Álvarez-Calderón, Carmen Panizo, Ricardo Abengozar, César Alías, Ali Al-Baech, José Arias-Irigoyen, M. José Caballero, Lluis Conill, Silvia de Miguel, Rafael Laguna, Joan Martínez-Benazet, Francisco Matoses, Jose Camilo Martínez-Alonso, Lourdes Mendizábal, Celsa Pérez-Carral…
    Citation: Clinical and Molecular Allergy 2017 15:1
    Content type: Research Published on:

  25. The tapeworm Taenia (T.) solium can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tis...

    Authors: Paola Lucia Minciullo, Antonio Cascio, Stefania Isola and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2016 14:18
    Content type: Review Published on:

  26. Eosinophilic diseases of the gastrointestinal tract, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), are rare chronic pathologies of the digestive system, with an immuno-mediat...

    Authors: Erminia Ridolo, Valerie Melli, Gianluigi De’ Angelis and Irene Martignago
    Citation: Clinical and Molecular Allergy 2016 14:17
    Content type: Review Published on:

  27. CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that ch...

    Authors: Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato and Lorenzo Cosmi
    Citation: Clinical and Molecular Allergy 2016 14:16
    Content type: Research Published on:

  28. The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal enviro...

    Authors: Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Antonio Lobasso, Filomena Napolitano, Francescopaolo Granata, Carmine Selleri and Amato de Paulis
    Citation: Clinical and Molecular Allergy 2016 14:15
    Content type: Research Published on:

  30. Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involveme...

    Authors: Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Donatella Sangari, Santa Cirmi, Roneka L. Ravenell, Michele Navarra, Gianfilippo Bagnato and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2016 14:13
    Content type: Case Report Published on:

  31. This meta-analysis compared the health-related quality of life (HRQL) of patients with allergic rhinitis (AR) and/or allergic asthma (AA) caused by perennial house dust mite (HDM) versus AR and/or AA caused by...

    Authors: A. Linneberg, K. Dam Petersen, J. Hahn-Pedersen, E. Hammerby, N. Serup-Hansen and N. Boxall
    Citation: Clinical and Molecular Allergy 2016 14:12
    Content type: Review Published on:

  32. Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of different effectors mechanisms of the immune system, namely antibodies and T cells. Their occurrence may be associated with...

    Authors: Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Paola Parronchi and Sergio Romagnani
    Citation: Clinical and Molecular Allergy 2016 14:11
    Content type: Review Published on:

  33. The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the...

    Authors: Paola Lucia Minciullo, Giovanni Paolino, Maddalena Vacca, Sebastiano Gangemi and Eustachio Nettis
    Citation: Clinical and Molecular Allergy 2016 14:10
    Content type: Review Published on:

  34. Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multi...

    Authors: Mona-Rita Yacoub, Alvise Berti, Corrado Campochiaro, Enrico Tombetti, Giuseppe Alvise Ramirez, Andrea Nico, Elisabetta Di Leo, Paola Fantini, Maria Grazia Sabbadini, Eustachio Nettis and Giselda Colombo
    Citation: Clinical and Molecular Allergy 2016 14:9
    Content type: Review Published on:

  35. Children with atopic dermatitis (AD) are at risk of developing allergy. Alongside clinical history, testing modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) and recently, microarra...

    Authors: Ru-Xin Foong, Graham Roberts, Adam Tobias Fox and George du Toit
    Citation: Clinical and Molecular Allergy 2016 14:8
    Content type: Research Published on:

  36. Airborne allergens can induce an immunological chronic disease characterized by airway hyper responsiveness and inflammation, mediated by exaggerated Th2 immune response. Allergen-specific immunotherapy (AIT) ...

    Authors: Claudia Petrarca, Emanuela Clemente, Valentina Amato, Alessia Gatta, Sara Cortese, Alessia Lamolinara, Cosmo Rossi, Stefania Zanotta, Gianni Mistrello, Roberto Paganelli and Mario Di Gioacchino
    Citation: Clinical and Molecular Allergy 2016 14:7
    Content type: Research Published on:

  37. Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the presence of antiphospholipid antibodies (aPL) in subjects presenting with thrombosis and/or pregnancy loss. The currently used cl...

    Authors: Savino Sciascia, Simone Baldovino, Karen Schreiber, Laura Solfietti, Massimo Radin, Maria J. Cuadrado, Elisa Menegatti, Doruk Erkan and Dario Roccatello
    Citation: Clinical and Molecular Allergy 2016 14:6
    Content type: Review Published on:

  38. In a historical period in which sustainability of the National Health Service is mandatory because of the international economical situation, the limited available resources at national level and the tendency ...

    Authors: Carlo Lombardi, Eleonora Savi, Maria Teresa Costantino, Enrico Heffler, Manlio Milanese, Giovanni Passalacqua and Giorgio Walter Canonica
    Citation: Clinical and Molecular Allergy 2016 14:5
    Content type: Commentary Published on:

  39. Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in t...

    Authors: Darío Antolín-Amérigo, Luis Manso, Marco Caminati, Belén de la Hoz Caballer, Inmaculada Cerecedo, Alfonso Muriel, Mercedes Rodríguez-Rodríguez, José Barbarroja-Escudero, María José Sánchez-González, Beatriz Huertas-Barbudo and Melchor Alvarez-Mon
    Citation: Clinical and Molecular Allergy 2016 14:4
    Content type: Review Published on:

  40. Cross-reactivity among Hymenoptera venoms is an important issue when prescribing venom immunotherapy (VIT). Using all venoms eliciting a positive response results in treatment excess and unjustified cost incre...

    Authors: Eleonora Savi, Silvia Peveri, Elena Makri, Valerio Pravettoni and Cristoforo Incorvaia
    Citation: Clinical and Molecular Allergy 2016 14:3
    Content type: Research Published on:

  41. Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria ...

    Authors: Lorenzo Drago, Roberta De Grandi, Gianfranco Altomare, Paolo Pigatto, Oliviero Rossi and Marco Toscano
    Citation: Clinical and Molecular Allergy 2016 14:2
    Content type: Research Published on:

  42. Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involv...

    Authors: Letizia Lombardelli, Federica Logiodice, Maryse Aguerre-Girr, Ornela Kullolli, Herman Haller, Ysabel Casart, Alain Berrebi, Fatima-Ezzahra L’Faqihi-Olive, Valérie Duplan, Sergio Romagnani, Enrico Maggi, Daniel Rukavina, Philippe Le Bouteiller and Marie-Pierre Piccinni
    Citation: Clinical and Molecular Allergy 2016 14:1
    Content type: Research Published on:

  43. Authors: Donatella Macchia, Giovanni Melioli, Valerio Pravettoni, Eleonora Nucera, Marta Piantanida, Marco Caminati, Corrado Campochiaro, Mona-Rita Yacoub, Domenico Schiavino, Roberto Paganelli and Mario Di Gioacchino
    Citation: Clinical and Molecular Allergy 2015 13:31
    Content type: Erratum Published on:

    The original article was published in Clinical and Molecular Allergy 2015 13:27

  44. Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE ch...

    Authors: Valerio Pravettoni, Marta Piantanida, Laura Primavesi, Stella Forti and Elide A. Pastorello
    Citation: Clinical and Molecular Allergy 2015 13:29
    Content type: Research Published on:

  45. In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlat...

    Authors: Carina Gabriela Uasuf, Danilo Villalta, Maria Elisabetta Conte, Caterina Di Sano, Maria Barrale, Vincenzo Cantisano, Elisabetta Pace, Mark Gjomarkaj, Sebastiano Gangemi and Ignazio Brusca
    Citation: Clinical and Molecular Allergy 2015 13:30
    Content type: Research Published on:

  46. One of the main problem health care systems are facis is the mis-use and over-use of medical resources (including useless exams, surgical interventions, medical treatments, screening procedures…) which may lea...

    Authors: Enrico Heffler, Massimo Landi, Silvana Quadrino, Cristoforo Incorvaia, Stefano Pizzimenti, Sandra Vernero, Nunzio Crimi, Giovanni Rolla and Giorgio Walter Canonica
    Citation: Clinical and Molecular Allergy 2015 13:28
    Content type: Research Published on:

  47. Published data suggest that asthma is significantly under/misdiagnosed. The present community-based study performed in Italy aims at investigating the level of asthma under/misdiagnosis among patients referrin...

    Authors: Maria Sandra Magnoni, Marco Caminati, Gianenrico Senna, Fabio Arpinelli, Andrea Rizzi, Anna Rita Dama, Michele Schiappoli, Germano Bettoncelli and Gaetano Caramori
    Citation: Clinical and Molecular Allergy 2015 13:26
    Content type: Research Published on:

  48. Clinically amyopathic dermatomyositis (CADM), described almost 50 years ago, is defined on the basis of still not validated criteria and characterized by skin findings almost without muscle weakness. Autoantib...

    Authors: Paola Parronchi, Anna Radice, Boaz Palterer, Francesco Liotta and Cristina Scaletti
    Citation: Clinical and Molecular Allergy 2015 13:22
    Content type: Review Published on:

  49. In the few studies available, the risk of developing systemic reactions (SR) to hymenoptera stings in patients with previous large local reactions (LLRs) to stings ranges from 0 to 7 %. We evaluated both retro...

    Authors: Stefano Pucci, Simona D’Alò, Tiziana De Pasquale, Ilenia Illuminati, Elena Makri and Cristoforo Incorvaia
    Citation: Clinical and Molecular Allergy 2015 13:21
    Content type: Research Published on:

  50. General practitioners (GPs), community pharmacists and allergic rhinitis (AR) patients in Italy were surveyed in order to gain insight from all three perspectives into the diagnosis, management and burden of A...

    Authors: G. Walter Canonica, Massimo Triggiani and GianEnrico Senna
    Citation: Clinical and Molecular Allergy 2015 13:25
    Content type: Research Published on:


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