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  1. Content type: Research

    β-lactam allergy is the most commonly reported medication allergy and it remains a key issue in antibiotic prescribing. A detailed and accurate history taking play a key role in preventing potentially serious ...

    Authors: Giovanni Satta, Victoria Hill, Marisa Lanzman and Indran Balakrishnan

    Citation: Clinical and Molecular Allergy 2013 11:2

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  2. Content type: Research

    T regulatory (Treg) cells are important in balancing immune responses and dysregulation of Treg cells has been implicated in the pathogenesis of multiple disease states including asthma. In this study, our pri...

    Authors: Anne Marie Singh, Paul Dahlberg, Kristjan Burmeister, Michael D Evans, Ronald Gangnon, Kathy A Roberg, Christopher Tisler, Douglas DaSilva, Tressa Pappas, Lisa Salazar, Robert F Lemanske Jr, James E Gern and Christine M Seroogy

    Citation: Clinical and Molecular Allergy 2013 11:1

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  3. Content type: Research

    Thymic stromal lymphopoietin (TSLP) and eosinophils are prominent components of allergic inflammation. Therefore, we sought to determine whether TSLP could activate eosinophils, focusing on measuring the regul...

    Authors: Ellen B Cook, James L Stahl, Elizabeth A Schwantes, Kristen E Fox and Sameer K Mathur

    Citation: Clinical and Molecular Allergy 2012 10:8

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  4. Content type: Research

    Grass pollen is a major cause of respiratory allergy worldwide and contain a number of allergens, some of theme (Phl p 1, Phl p 2, Phl p 5, and Phl 6 from Phleum pratense, and their homologous in other grasses) a...

    Authors: Francesco Marcucci, Laura Sensi, Cristoforo Incorvaia, Ilaria Dell’Albani, Giuseppe Di Cara and Franco Frati

    Citation: Clinical and Molecular Allergy 2012 10:7

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  5. Content type: Case Report

    Major histocompatibility complex class II deficiency, also referred to as bare lymphocyte syndrome is a rare primary Immunodeficiency disorder characterized by a profondly deficient human leukocyte antigen cla...

    Authors: Naouel Guirat-Dhouib, Yemen Baccar, Imène Ben Mustapha, Monia Ouederni, Sameh Chouaibi, Nadia El Fekih, Mohamed Ridha Barbouche, Bassima Fezaa, Ridha Kouki, Slama Hmida, Fethi Mellouli and Mohamed Bejaoui

    Citation: Clinical and Molecular Allergy 2012 10:6

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  6. Content type: Review

    While most allergic responses to food are directed against protein epitopes and occur within 30 minutes of ingesting the allergen, recent studies suggest that delayed reactions may occur, sometimes mediated by...

    Authors: Hana Saleh, Scott Embry, Andromeda Nauli, Seif Atyia and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2012 10:5

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  7. Content type: Research

    Human mast cells are capable of a wide variety of inflammatory responses and play a vital role in the pathogenesis of inflammatory diseases such as allergy, asthma, and atherosclerosis. We have reported that c...

    Authors: David S Chi, Ta-Chang Lin, Kenton Hall, Tuanzhu Ha, Chuanfu Li, Zong Doa Wu, Thomas Soike and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2012 10:3

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  8. Content type: Research

    Clara cell protein (CC16) is ascribed a protective and anti-inflammatory role in airway inflammation. Lower levels have been observed in asthmatic subjects as well as in subjects with intermittent allergic rhi...

    Authors: Kristina Irander, Jörgen P Palm, Magnus P Borres and Bijar Ghafouri

    Citation: Clinical and Molecular Allergy 2012 10:4

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  9. Content type: Research

    The phenomena manifested during inflammation require interplay between circulating effector cells, local resident cells, soluble mediators and genetic host factors to establish, develop and maintain itself. Of...

    Authors: Ena Ray Banerjee and William R Henderson Jr

    Citation: Clinical and Molecular Allergy 2012 10:2

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  10. Content type: Research

    Cow's milk allergy is one of the most common food allergies among younger children. We investigated IgE antibodies to milk, and IgE and IgG4 antibodies to casein, α-lactalbumin and β-lactoglobulin in cow's mil...

    Authors: Komei Ito, Masaki Futamura, Robert Movérare, Akira Tanaka, Tsutomu Kawabe, Tatsuo Sakamoto and Magnus P Borres

    Citation: Clinical and Molecular Allergy 2012 10:1

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  11. Content type: Review

    Type 1 hyper IgE syndrome (HIES), also known as Job's Syndrome, is an autosomal dominant disorder due to defects in STAT3 signaling and Th17 differentiation. Symptoms may present during infancy but diagnosis i...

    Authors: Wilson S Robinson, Sandra R Arnold, Christie F Michael, John D Vickery, Robert A Schoumacher, Eniko K Pivnick, Jewell C Ward, Vijaya Nagabhushanam and Dukhee B Lew

    Citation: Clinical and Molecular Allergy 2011 9:14

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  12. Content type: Review

    Chronic Granulomatous Disease (CGD), a disorder of the NADPH oxidase system, results in phagocyte functional defects and subsequent infections with bacterial and fungal pathogens (such as Aspergillus species and

    Authors: Casey E Watkins, John Litchfield, Eunkyung Song, Gayatri B Jaishankar, Niva Misra, Nikhil Holla, Michelle Duffourc and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2011 9:13

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  13. Content type: Research

    To examine whether whole genome expression profiling could reveal changes in mRNA expression of peripheral blood mononuclear cells (PBMC) from allergic patients undergoing rush immunotherapy (RIT) that might b...

    Authors: Laurie S Davis, Sumit Bhutani, Sherry Ridz Barnett and David A Khan

    Citation: Clinical and Molecular Allergy 2011 9:12

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  14. Content type: Commentary

    Omalizumab, a humanized monoclonal anti-IgE antibody has the potential to alter allergen processing. Recently, it has been postulated the assessment of PHA-stimulated adenosine triphosphate (ATP) activity as m...

    Authors: Inmaculada Sánchez-Machín, Javier Iglesias-Souto, Andrés Franco, Yvelise Barrios, Ruperto Gonzalez and Víctor Matheu

    Citation: Clinical and Molecular Allergy 2011 9:11

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  15. Content type: Review

    Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formatio...

    Authors: EunKyung Song, Gayatri Bala Jaishankar, Hana Saleh, Warit Jithpratuck, Ryan Sahni and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2011 9:10

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  16. Content type: Review

    Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthr...

    Authors: Warit Jithpratuck, Yasmin Elshenawy, Hana Saleh, George Youngberg, David S Chi and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2011 9:9

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  17. Content type: Research

    Objective markers of early airway inflammation in infants are not established but are of great interest in a scientific setting. Exhaled nitric oxide (FeNO) and urinary eosinophilic protein X (uEPX) are a two ...

    Authors: Fredrik Carlstedt, Dagmara Lazowska, Carl-Gustaf Bornehag, Anna-Carin Olin and Mikael Hasselgren

    Citation: Clinical and Molecular Allergy 2011 9:8

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  18. Content type: Research

    Anti-IgE therapy inhibits mast cell and basophil activation, blocks IgE binding to both FcεRI and CD23 and down regulates FcεRI expression by antigen (Ag) presenting cells (APCs). In addition to its classical ...

    Authors: Barbara Foster, Shabnam Foroughi, Yuzhi Yin and Calman Prussin

    Citation: Clinical and Molecular Allergy 2011 9:7

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  19. Content type: Review

    The field of primary immunodeficiencies (PIDs) is one of several in the area of clinical immunology that has not been static, but rather has shown exponential growth due to enhanced physician, scientist and pa...

    Authors: Roshini S Abraham

    Citation: Clinical and Molecular Allergy 2011 9:6

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  20. Content type: Research

    In 2006, the Norwegian Medicines Agency mandated a switch from desloratadine, ebastine, or fexofenadine to cetirizine or loratadine in patients with allergic rhinitis (AR) or chronic urticaria (CU). In an onli...

    Authors: Fredrik Thorn, Halvor Celius, Tone Ødegård, Randeep Mandla and Erik Hexeberg

    Citation: Clinical and Molecular Allergy 2011 9:5

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  21. Content type: Research

    Atopic dermatitis is a chronic, allergic inflammatory skin disease that is accompanied by markedly increased levels of inflammatory cells, including eosinophils, mast cells, and T cells. Arctium lappa L. is a tra...

    Authors: Eun-Hwa Sohn, Seon-A Jang, Haemi Joo, Sulkyoung Park, Se-Chan Kang, Chul-Hoon Lee and Sun-Young Kim

    Citation: Clinical and Molecular Allergy 2011 9:4

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  22. Content type: Research

    Patients with allergic rhinitis and allergic asthma demonstrate comparable local and systemic eosinophil inflammation, and yet they present with different clinical pictures. Less is even known about the contri...

    Authors: Mary Kämpe, Ingrid Stolt, Maria Lampinen, Christer Janson, Gunnemar Stålenheim and Marie Carlson

    Citation: Clinical and Molecular Allergy 2011 9:3

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  23. Content type: Case Report

    Chronic idiopathic urticaria is a condition that is often controllable with antihistamine therapy. However, some patients have disease burden that is difficult to manage, non-responsive to antihistamines and o...

    Authors: Michael C Saavedra and Sanjiv Sur

    Citation: Clinical and Molecular Allergy 2011 9:2

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  24. Content type: Research

    Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in ...

    Authors: Supinda Bunyavanich, Erik Melen, Jemma B Wilk, Mark Granada, Manuel E Soto-Quiros, Lydiana Avila, Jessica Lasky-Su, Gary M Hunninghake, Magnus Wickman, Göran Pershagen, George T O'Connor, Scott T Weiss and Juan C Celedόn

    Citation: Clinical and Molecular Allergy 2011 9:1

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  25. Content type: Case Report

    Skin prick testing is widely used to predict the presence of allergen-specific IgE. In eosinophilic esophagitis patients, who frequently exhibit polysensitization and broad reactivity upon skin prick testing, ...

    Authors: Toral A Kamdar, Anne M Ditto and Paul J Bryce

    Citation: Clinical and Molecular Allergy 2010 8:16

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  26. Content type: Research

    A. fumigatus has been associated with a wide spectrum of allergic disorders such as ABPA or SAFS. It is poorly understood what allergens in particular are being expressed during fungal invasion and which are resp...

    Authors: Marcin G Fraczek, Rifat Rashid, Marian Denson, David W Denning and Paul Bowyer

    Citation: Clinical and Molecular Allergy 2010 8:15

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  27. Content type: Research

    Histamine-metabolizing enzymes (N-methyltransferase and amiloride binding protein 1) are responsible for histamine degradation, a biogenic amine involved in allergic inflammation. Genetic variants of HNMT and ABP...

    Authors: Aleksandra Szczepankiewicz, Anna Bręborowicz, Paulina Sobkowiak and Anna Popiel

    Citation: Clinical and Molecular Allergy 2010 8:14

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  28. Content type: Research

    Flavonoids, a large group of polyphenolic metabolites derived from plants have received a great deal of attention over the last several decades for their properties in inflammation and allergy. Quercetin, the ...

    Authors: Salvatore Chirumbolo, Marta Marzotto, Anita Conforti, Antonio Vella, Riccardo Ortolani and Paolo Bellavite

    Citation: Clinical and Molecular Allergy 2010 8:13

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  29. Content type: Case Report

    Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN...

    Authors: Haorile Chagan-Yasutan, Beata Shiratori, Umme Ruman Siddiqi, Hiroki Saitoh, Yugo Ashino, Tomohiro Arikawa, Mitsuomi Hirashima and Toshio Hattori

    Citation: Clinical and Molecular Allergy 2010 8:12

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  30. Content type: Research

    Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However, the association of allergen-induced cord blood mononuclear cel...

    Authors: Carolyn Chang, Kevin Gauvey-Kern, Alina Johnson, Elizabeth A Kelvin, Ginger L Chew, Frederica Perera and Rachel L Miller

    Citation: Clinical and Molecular Allergy 2010 8:11

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  31. Content type: Research

    Eosinophils are involved in various inflammatory processes including allergic inflammation during which angiogenesis has been documented. Angiogenesis is most likely connected to the hypoxia which characterize...

    Authors: Alon H Nissim Ben Efraim, Ron Eliashar and Francesca Levi-Schaffer

    Citation: Clinical and Molecular Allergy 2010 8:10

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  32. Content type: Research

    The mechanism(s) responsible for the reduced risk of allergic disease in breastfed infants are not fully understood. Using an established murine model of asthma, we demonstrated previously that resistance to a...

    Authors: Adam P Matson, Roger S Thrall, Ektor Rafti, Elizabeth G Lingenheld and Lynn Puddington

    Citation: Clinical and Molecular Allergy 2010 8:9

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  33. Content type: Research

    Atopic dermatitis (AD) is often the prelude to allergic diseases. The aim of this study was 1) to evaluate if an integrated management regime could bring about a change in the evolution of the disease in compa...

    Authors: Giampaolo Ricci, Annalisa Patrizi, Arianna Giannetti, Arianna Dondi, Barbara Bendandi and Massimo Masi

    Citation: Clinical and Molecular Allergy 2010 8:8

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  34. Content type: Research

    Hymenoptera venoms are known to cause life-threatening IgE-mediated anaphylactic reactions in allergic individuals. Proper diagnosis of hymenoptera venom allergy using venom extracts is severely affected by mo...

    Authors: Henning Seismann, Simon Blank, Liliana Cifuentes, Ingke Braren, Reinhard Bredehorst, Thomas Grunwald, Markus Ollert and Edzard Spillner

    Citation: Clinical and Molecular Allergy 2010 8:7

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  35. Content type: Review

    Mannose-binding lectin (MBL) and the Mannose-binding lectin-associated serine proteases (MASPs) are an essential aspect of innate immune responses that probably play an important but understudied role in cutan...

    Authors: Christopher Miller, Sara Wilgenbusch, Mini Michael, David S Chi, George Youngberg and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2010 8:6

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  36. Content type: Research

    Asthma afflicts 6% to 8% of the United States population, and severe asthma represents approximately 10% of asthmatic patients. Several epidemiologic studies in the United States and Europe have linked Alternaria

    Authors: Alan P Knutsen, Hari M Vijay, Barbara Kariuki, Luis A Santiago, Ralph Graff, Jonathan D Wofford and Maulik R Shah

    Citation: Clinical and Molecular Allergy 2010 8:5

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  37. Content type: Research

    Some studies reported the possible induction of food allergy, caused by neo-sensitization to cross-reacting allergens, during immunotherapy with aeroallergens, while other studies ruled out such possibility.

    Authors: Renato E Rossi, Giorgio Monasterolo, Cristoforo Incorvaia, Philippe Moingeon, Franco Frati, Giovanni Passalacqua, Lucilla Rossi and Giorgio W Canonica

    Citation: Clinical and Molecular Allergy 2010 8:4

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  38. Content type: Review

    Altered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecul...

    Authors: Mariah B Pate, John Kelly Smith, David S Chi and Guha Krishnaswamy

    Citation: Clinical and Molecular Allergy 2010 8:3

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  39. Content type: Research

    Subcutaneous Immunotherapy (SCIT) modifies the allergic response and relieves allergic symptoms. SCIT is the only and a very effective treatment for insect venom allergy. We hypothesized that basophil sensitiv...

    Authors: Susan Mikkelsen, Bo Martin Bibby, Mette Konow Bøgebjerg Dolberg, Ronald Dahl and Hans Jürgen Hoffmann

    Citation: Clinical and Molecular Allergy 2010 8:2

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  40. Content type: Review

    Rhinitis is characterized by rhinorrhea, sneezing, nasal congestion, nasal itch and/or postnasal drip. Often the first step in arriving at a diagnosis is to exclude or diagnose sensitivity to inhalant allergen...

    Authors: Cyrus H Nozad, L Madison Michael, D Betty Lew and Christie F Michael

    Citation: Clinical and Molecular Allergy 2010 8:1

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  41. Content type: Case Report

    Sensitization to Thyreophagus entomophagus, a storage mite, is uncommon and might produce occupational respiratory disorders in farmers. We present the first case of a child suffering anaphylaxis produced by inge...

    Authors: Javier Iglesias-Souto, Inmaculada Sánchez-Machín, Víctor Iraola, Paloma Poza, Ruperto González and Víctor Matheu

    Citation: Clinical and Molecular Allergy 2009 7:10

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  42. Content type: Research

    The use of biotechnological techniques to introduce novel proteins into food crops (transgenic or GM crops) has motivated investigation into the properties of proteins that favor their potential to elicit alle...

    Authors: Rod A Herman, Ping Song and Arvind ThirumalaiswamySekhar

    Citation: Clinical and Molecular Allergy 2009 7:9

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  43. Content type: Research

    In the United States, asthma prevalence is particularly high among urban children. Although the underlying immune mechanism contributing to asthma has not been identified, having impaired T regulatory (Treg) c...

    Authors: Ngoc P Ly, Begona Ruiz-Perez, Rachel M McLoughlin, Cynthia M Visness, Paul K Wallace, William W Cruikshank, Arthur O Tzianabos, George T O'Connor, Diane R Gold and James E Gern

    Citation: Clinical and Molecular Allergy 2009 7:8

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  44. Content type: Review

    Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized s...

    Authors: Amrendra Kumar and Balaram Ghosh

    Citation: Clinical and Molecular Allergy 2009 7:7

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  47. Content type: Review

    Though not widely recognized, food hypersensitivity by inhalation can cause major morbidity in affected individuals. The exposure is usually more obvious and often substantial in occupational environments but ...

    Authors: Daniel A Ramirez Jr and Sami L Bahna

    Citation: Clinical and Molecular Allergy 2009 7:4

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  48. Content type: Research

    Bermuda grass (Cynodon dactylon; subfamily Chloridoideae) is an important source of seasonal aeroallergens in warm tropical and sub-tropical areas worldwide. Improved approaches to diagnosis and therapy of allerg...

    Authors: Ruby Tiwari, Prem L Bhalla and Mohan B Singh

    Citation: Clinical and Molecular Allergy 2009 7:3

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  49. Content type: Review

    Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition, recent evidence strongly suggests that viral infections may also have a causal role in the development ...

    Authors: Matthew M Huckabee and R Stokes Peebles Jr

    Citation: Clinical and Molecular Allergy 2009 7:2

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  50. Content type: Review

    Food allergies affect an estimated 3 to 4% of adults and up to 8% of children in developed western countries. Results from in vitro simulated gastric digestion studies with purified proteins are routinely used to...

    Authors: Santiago Schnell and Rod A Herman

    Citation: Clinical and Molecular Allergy 2009 7:1

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Clinical and Molecular Allergy

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