- Open Access
Clinical management, expectations, and satisfaction of patients with moderate to severe allergic rhinoconjunctivitis treated with SQ-standardized grass-allergen tablet under routine clinical practice conditions in Spain
- Tomás Chivato1Email author,
- Pedro Álvarez-Calderón2,
- Carmen Panizo3,
- Ricardo Abengozar4,
- César Alías5,
- Ali Al-Baech6,
- José Arias-Irigoyen6,
- M. José Caballero7,
- Lluis Conill8,
- Silvia de Miguel9,
- Rafael Laguna10,
- Joan Martínez-Benazet11,
- Francisco Matoses12,
- Jose Camilo Martínez-Alonso13,
- Lourdes Mendizábal14,
- Celsa Pérez-Carral15,
- Carlos Puerto16,
- Joan Serra-Batllés17,
- Adolfo Vélez18,
- Jonathan Vicente19 and
- Fernando de la Torre20
© The Author(s) 2017
- Received: 28 October 2016
- Accepted: 18 December 2016
- Published: 6 January 2017
Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX® is the most documented product in terms of safety and efficacy. The objective of this study was to identify the patients’ expectations and level of treatment satisfaction, as well as the clinical management of patients with moderate/severe allergic rhinoconjunctivitis treated with GRAZAX®.
This was a non-interventional, observational, multi-centre, open-label study involving a total of 131 adult patients aged 18–66 years with confirmed diagnosis of grass-allergy and initiated treatment with GRAZAX® between June 2010 and April 2011.
In the pollen season after starting treatment, 56.6% of patients stated that their symptoms were much less/less intense, 86% needed less symptomatic medication for control of their symptoms, and 74.4% manifested to have improved (quite/a lot) as regards their allergic disease since treatment was initiated as compared with previous grass pollen season. The patient satisfaction with GRAZAX® was measured using a visual analogue scale (VAS) between 0 (minimum satisfaction) and 100 (maximum satisfaction) comprising five different items: effectiveness, tolerability, cost, convenience and overall satisfaction. The results obtained for each item were [mean (SD)]: 74.7 (18.1), 70.3 (36.1), 39.3 (25.8), 86.2 (12.6), 78.4 (15.8) respectively. The patient’s level of satisfaction is highly influenced, especially in terms of assessment of effectiveness, tolerability and convenience, by the information provided by the specialist.
In summary, it can be concluded that improved communication leads to increased patient knowledge, greater patient compliance, and increased patient satisfaction.
- Allergic rhinitis
- Allergen immunotherapy tablet
- Clinical management
Despite not being considered a life-threatening disease, allergic rhinitis or rhinoconjunctivitis cause functional problems (physical, emotional, social, and occupational) that tend to worsen with time. Moreover, this disease represents a high cost burden for healthcare systems, often exceeding those derived from more serious conditions; allergic rhinoconjunctivitis is very common , affecting around one in four people of the total population. In a large-scale study that included over 9500 patients from Western European countries, the prevalence of allergic rhinitis was found to be around 23%. Because it is frequently considered not to be a life-threatening disease, it often remains undiagnosed, resulting in inadequate control of the symptoms .
From an economic point of view, the consequences of allergic rhinoconjunctivitis are considerable in terms of direct (treatments and visits to the GP/specialist) and indirect (i.e., sick leave from work or school, sleep disorders, and disruption of daily activities) costs.
Grasses are one of the most common causes of allergic rhinitis, having a clear impact on patients’ quality of life . There are various options for the management of this condition: symptomatic medication for the relief of the symptoms and avoidance of allergen exposure. On the other hand, the underlying cause of the allergic disease can be targeted through allergen-specific immunotherapy. Although proven effective, subcutaneous administration of the allergen can be uncomfortable and time-consuming. Sublingual allergen immunotherapy has been the subject of clinical development over the last 20 years. A Cochrane review published in 2011  concluded that the use of sublingual immunotherapy for allergic rhinitis and rhinoconjunctivitis is effective and is not associated with significant adverse events.
Regarding sublingual immunotherapy, the grass allergen tablet GRAZAX® (Phleum pratense 75,000 SQ-T/2800 BAU, ALK, Denmark) is the most documented product in terms of safety and efficacy in children and adults [4–12].
However, several aspects of this therapeutic alternative, which tend to be closely associated with therapeutic adherence, have not been thoroughly examined, as for example: patients’ expectations and their knowledge concerning a certain treatment [13, 14], the administration routes for immunotherapy , patient satisfaction with this treatment , and certain clinical management and patient education factors that may help reinforce positive patient behaviour regarding the treatment [17, 18].
The purpose of this study is to determine the expectations and level of satisfaction of patients (using the data collected from a questionnaire), as well as to collect information regarding the clinical management of patients with moderate/severe allergic rhinoconjunctivitis treated with GRAZAX®.
Design, treatment, and patients
Non-interventional, observational, multicenter, open-label study that included one hundred and thirty-one (131) adult patients aged between 18 and 66 years. All study subjects had a confirmed diagnosis of grass pollen allergy, reached through routine clinical practice (positive prick test and/or specific IgE) and had initiated treatment with GRAZAX® between June 2010 and April 2011 (i.e., had started treatment at least 2 months before the beginning of the 2011 grass pollen season). Two patients were excluded from the study because they were under 18 years of age.
Written informed consent was obtained from all patients before their inclusion in the study. The corresponding health authorities and the ethics committee approved the study.
Patients enrolled in the study were provided with a questionnaire comprising 18 questions and a visual analogue scale (VAS). The questionnaire was answered by the study subjects and aimed to assess their state of health and knowledge and expectations regarding the treatment with GRAZAX®; the VAS scoring ranged from not at all satisfied (0) to maximum satisfaction (100).
Current patient satisfaction to our knowledge, there is no standardised validated tool for this patient population. Thus, this variable was assessed through items specifically designed for this study. The ad hoc items in the study included Likert-type response options or visual analogue scorings.
Patients’ expectations at the start of treatment and at present a series of ad hoc items were drawn up. Data regarding the information patients received about their illness and treatment were also collected.
Clinical management received by patients certain characteristic aspects of patients’ perception regarding their clinical management.
Study data was collected retrospectively the year before the inclusion of the patients in the study. There was no follow-up of the participants as the study consisted of a single visit for data collection. Sociodemographic and clinical data were also collected.
Nonparametric tests (bilateral Kolmogorov–Smirnov test with 95% confidence level) were used to assess the normal distribution of the variables. Statistical inference was obtained by bivariate or multivariate analyses. The bivariate analyses were parametric (Chi squared, Student’s t distribution, ANOVA) or bilateral nonparametric (Fisher’s exact, Mann–Whitney, Kruskal–Wallis), with a 95% confidence level.
Characteristics of patients
Clinical characteristics of the rhinitis
Characteristics of allergic rhinitis
% of patients
Interference with daily activities
Interference with working activities or studies
Symptomatic medication used for rhinitis
35.7% of study patients were monosensitized to grass, from which 64.3% were sensitized to grass and other allergens (these patients were considered as polysensitized). The most frequent allergens affecting the latter group were pollens (Olea: 33.7%; Cupressus: 26.5%; Plantago: 24.1%), mites (D. pteronyssinus: 28.9%), moulds (Alternaria: 9.6%), and epithelia (cat: 24.1%; dog: 20.5%).
Patients’ expectations at the beginning of the treatment and at present
Knowledge and expectations regarding the allergen immunotherapy tablet
In your opinion, which is the aim of an allergen treatment? (n = 126)
Reduce the number of attacks
Prevent life-threatening events
Avoid the development of new allergies
What do you expect from your treatment with the allergen immunotherapy tablet? (n = 128)
Complete cure of the allergy
Some improvement of the symptoms
Avoid the development of new allergies
Prevent the onset of asthma symptoms
When do you think the allergen immunotherapy tablet will start to be effective? (n = 123)
In a few days or weeks
In a few months
In a few years
Do you think the treatment could be dangerous or cause adverse events? (n = 115)
The allergen immunotherapy tablet is safe
When the answers in different subgroups of patients based on age, sex, mono-/polysensitized, years of evolvement of the allergic disease, or type and severity of allergic rhinitis were analysed, statistically significant differences were only found for the expectations regarding treatment. Thus, whereas 41.7% of patients with mild rhinitis expected a complete cure, this percentage increased to 64.9% (p = 0.042) in patients with moderate-severe rhinitis.
Clinical management of the patients
Clinical information received by the patients
Did you receive information about your disease before starting the treatment with the allergen immunotherapy tablet? (n = 128)
Yes, in detail
Yes, a little
Did you receive information about the different treatments for your disease? (n = 129)
Yes, in detail
Yes, a little
I received no information
Did you receive information about the characteristics of the allergen immunotherapy tablet? (n = 128)
Yes, in detail
Yes, a little
I received no information
Did you receive written information about your disease or its treatment? (n = 128)
During the pollen season, 56.6% of patients stated their symptoms were much less/less intense, 86% required less symptomatic medication for the control of their allergic symptoms, and 74.4% stated the allergic disease had improved (quite/a lot) since the initiation of the treatment with GRAZAX® in comparison with the previous grass pollen season.
Level of satisfaction of patients treated with GRAZAX®
Patients´ satisfaction with GRAZAX® was measured using a visual analogue scale (VAS) with a range of scores between 0 (minimum satisfaction) and 100 (maximum satisfaction) comprising five items: effectiveness, tolerability, cost, convenience, and overall satisfaction. The following results, expressed as means (SD), were obtained for each item: 74.7 (18.1), 70.3 (36.1), 39.3 (25.8), 86.2 (12.6), 78.4 (15.8), respectively. No statistically significant differences were found between these variables regarding the age and sex of the patients.
Degree of satisfaction with the allergen immunotherapy tablet as per the severity of the allergic rhinitis (VAS scale: 0 -not at all satisfied-, 100 -maximum satisfaction-)
Relationship between patient satisfaction and disease- and treatment-related information received
Before starting the treatment, did your doctor speak to you about the disease?
Yes, at length
Yes, a little
Did your doctor speak to you about the different possible treatments for your disease?
Yes, at length
Yes, a little
Did your doctor speak to you about the characteristics of GRAZAX®?
Yes, at length
Yes, a little
Finally, overall patient satisfaction with GRAZAX® with respect to previous immunotherapy treatments showed that 56.36% of the patients considered GRAZAX® as “much better” and 30.9% as “better”.
Allergic rhinoconjunctivitis and rhinitis are independent risk factors for asthma. These two conditions increase the social and economic impact of asthma and represent an important burden for the healthcare system [2, 20]. Data on drug intake, healthcare resources, days of work missed, and loss of productivity associated to allergic rhinitis were collected by the Spanish Society of Allergy and Clinical Immunology (SEAIC).
The management of allergic rhinitis involves different strategies, including patient education, allergen avoidance, and symptomatic and etiological treatments. Within this latter option, GRAZAX® is the only product authorized for treating grass pollen allergy with a registered disease-modifying effect . According to the results obtained in the clinical trials performed with GRAZAX®, a significant clinical benefit is achieved after the first 4 months of treatment . For this reason the authors assumed that 1 year of treatment could be an acceptable time for evaluating the satisfaction and expectations of patients.
The healthcare system could benefit from an annual increase in the number of patients treated with specific immunotherapy in terms of additional cost savings and improved health status for the patients . In this study we show that 86% of patients treated with GRAZAX® take less symptomatic medication after starting the treatment, which implies lower costs for the national healthcare system. These findings are in line with a previous study by Donahue et al. . who found immunotherapy to be a less cost-intensive strategy than standard pharmacotherapy over a 10-year period. Treatment with GRAZAX® has been described in the literature to be a cost-effective intervention for the prevention of grass pollen-induced rhinoconjunctivitis [23, 24]. However, factors related to patient satisfaction and expectations have not been thoroughly studied, despite their key role in the therapeutic strategy.
The relevance of quality of life for these patients is reflected in the fact that 65.9% consider an improvement in this aspect to be the main treatment goal. On the other hand, opinions among patients regarding treatment safety are divided and complete information is crucial to ensure treatment adherence. A recent study with GRAZAX®  showed that all but one of the adverse reactions registered with the first dose occurred within the observation period specified in the SmPC for the used dose. The appropriate management of the patient´s reaction to this first dose, along with medical support, can help prevent treatment withdrawal. Physician-patient agreement, physician’s ability to deal with all the patient’s problems, and taking into consideration his/her expectations, feelings, and ideas are key for the final outcome.
It is generally accepted that better clinical benefits are achieved when treatment is started in early stages of a disease. In this study, patients who have had the disease for a shorter time, asses the effectiveness of the allergen immunotherapy tablet significantly better in comparison with patients who have suffered the condition for a longer time (<6 years: 78.2, 6–12 years: 76.4, >12 years: 69.7, p = 0.025).
In the Table 2, 33.9 and 36.5% feel that immunotherapy may be “sometimes” or “rarely” dangerous or may produce adverse events, respectively. With GRAZAX® the adverse reactions are more frequent in the beginning of the treatment and, in many patients, with the administration of the first dose and most of reaction occurred during the observation period after the administration of the first dose. When the doctor explains the type of adverse reactions that can be expected by the treatment, and considering that GRAZAX® is self-administered at patient´s home, the authors considered as relevant the perception of patients about the safety of treatment.
As for treatment adherence, most patients said to have received complete information about the disease and the treatment, although there was no written information (i.e., leaflets, etc.). Patients’ expectations are essential for adherence, and in this study a high percentage (between 25 and 40.5%) of the patients expected the treatment to have an effect “in days or weeks”. Patients should be encouraged to ask questions and be given clear verbal information by their physician, supplemented, whenever possible, by emotional support and written information packages.
Although it is clear that the intensity of the clinical management (number duration of the visits) affects various aspects of patient´s satisfaction, it is a non-linear effect, implying that other variables may influence this relationship. Determining whether physicians’ communication strategies have a direct effect on patient satisfaction ratings is not straightforward [26, 27]. Cohort studies to assess the effect of communication measures have to be designed and developed; however, strategies to promote treatment adherence should be based on the concept of user-friendly information and improved patient-health professional communication.
In summary, the level of satisfaction is closely related to the information given to the patients; satisfaction increases with the amount and type of explanations received from the physician (e.g., time explaining the disease, existing treatments, or specific information about the new tablet-based treatment). A better communication leads to increased patient knowledge, compliance, and satisfaction.
All the authors included patients and review the manuscript. Tomás Chivato wrote the manuscript. Fernando De la Torre performed the statistical analysis and contributed to the manuscript writing. All authors read and approved the final manuscript.
We thank Eva Baro (3D-Health) for her technical support.
Fernando de la Torre works for ALK-Abelló, S.A. The other authors declare no competing interests.
Written informed consent was obtained from all patients before their inclusion in the study. The corresponding health authorities and the ethics committee (Hospital Central de la Defensa “Gómez Ulla”. Madrid) approved the study (Reference Number 21-11).
Fund by ALK-Abelló, S.A.
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- Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J. 2004;24:758–64.View ArticlePubMedGoogle Scholar
- Bousquet J, van Cauwenberge P, Khaltaev N, ARIA Workshop Group, World Health Organization. Allergic rhinitis and its impact on asthma (ARIA). J Allergy Clin Immunol. 2001;108(5 Suppl):S147–334.View ArticlePubMedGoogle Scholar
- Radulovic S, Calderon MA, Wilson D, Durham S. Sublingual immunotherapy for allergic rhinitis (Review) 2011. Cochrane Database Syst Rev. 2010;12:CD002893.Google Scholar
- Malling HJ, Lund L, Ipsen H, Poulsen L. Safety and immunological changes during sublingual immunotherapy with standardized quality grass allergen tablets. JIACI. 2006;16:162–8.PubMedGoogle Scholar
- Durham S, Yang WH, Pedersen MR, Johansen N, Rak S. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. JACI. 2006;117:802–9.Google Scholar
- Calderon MA, Birk AO, Andersen JS, Durham SR. Prolonged pre-seasonal treatment phase with SLIT increases clinical efficacy. Allergy. 2007;62:958–61.View ArticlePubMedGoogle Scholar
- Bufe A, Eberle P, Franke-Beckmann E, Funck J, Kimming M, Klimek L, Knect R, Stephan V, Tholstrup B, WeiBhaar C, Kaiser F. Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy. J Allergy Clin Immunol. 2009;123:167–73.View ArticlePubMedGoogle Scholar
- Kleine-Tebbe J, Ribel M, Herold DA. Safety of a SQ-standardised grass allergen tablet for sublingual immunotherapy: a randomized, placebo-controlled trial. Allergy. 2006;61:181–4.View ArticlePubMedGoogle Scholar
- Dahl R, Kapp A, Colombo G, de Monchy JGR, Rak S, Emminger W, Fernández Rivas M, Ribel M, Durham S. Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. JACI. 2006;118:434–40.Google Scholar
- Durham S, Emminger W, Kapp A, Colombo G, de Monchy JGR, Rak S, Scadding GK, Andersen JS, Riis B. Long-term clinical efficacy in grass pollen rhinoconjunctivitis after treatment with SQ standardized grass allergy immunotherapy tablet. J Allergy Clin Immunol. 2010;125:131–8.View ArticlePubMedGoogle Scholar
- Rak S, Yang WH, Pedersen MR, Durham S. Once-daily sublingual allergen-specific immunotherapy improves quality of life in patients with grass pollen-induced allergic rhinoconjunctivitis: a double-blind, randomised study. Qual Life Res. 2007;16:191–201.View ArticlePubMedGoogle Scholar
- Frølund L, Durham SR, Calderon M, Emminger W, Andersen JS, Rask P, Dahl R. Sustained effect of SQ-standardized grass allergy immunotherapy tablet on rhinoconjunctivitis quality of life. Allergy. 2010;65:753–7.View ArticlePubMedGoogle Scholar
- Sade K, Berkun Y, Dolev Z, Shalit M, Kivity S. Knowledge and expectations of patients receiving aeroallergen immunotherapy. Ann Allergy Asthma Immunol. 2003;91:444–8.View ArticlePubMedGoogle Scholar
- Mahesh PA, Vedanthan PK, Amrutha DH, Giridhar BH, Prabhakar AK. Factors associated with non-adherence to specific allergen immunotherapy in management of respiratory allergy. Indian J Chest Dis Allied Sci. 2010;52:91–5.PubMedGoogle Scholar
- Pajno GB, Vita D, Caminiti L, Arrigo T, Lombardo F, Incorvaia C, Barberio G. Children’s compliance with allergen immunotherapy according to administration routes. J Allergy Clin Immunol. 2005;116:1380–1.View ArticlePubMedGoogle Scholar
- Ferrer M, Morais-Almeida M, Guizova M, Khanferyan R. Evaluation of treatment satisfaction in children with allergic disease treated with an antihistamine: an international, non-interventional, retrospective study. Clin Drug Investig. 2010;30:15–34.View ArticlePubMedGoogle Scholar
- Vita D, Caminiti L, Ruggeri P, Pajno GB. Sublingual immunotherapy: adherence based on timing and monitoring control visits. Allergy. 2010;65:668–9.View ArticlePubMedGoogle Scholar
- Incorvaia C, Rapetti A, Scurati S, Puccinelli P, Capecce M, Frati F. Importance of patient’s education in favouring compliance with sublingual immunotherapy. Allergy. 2010;65:1341–2.View ArticlePubMedGoogle Scholar
- GEMA (Guía española para el manejo del asma). Arch Bronconeumol. 2009;45(Supl 7):2–35.Google Scholar
- Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc. 2007;28:3–9.View ArticlePubMedGoogle Scholar
- Grazax® Summary of product characteristics.Google Scholar
- Donahue JG, Greineder DK, Connor-Lacke L, Canning CF, Platt R. Utilization and cost of immunotherapy for allergic asthma and rhinitis. Ann Allergy Asthma Immunol. 1999;82:339–47.View ArticlePubMedGoogle Scholar
- Canonica GW, Poulsen PB, Vestenbæk U. Cost-effectiveness of GRAZAX® for prevention of grass pollen induced rhinoconjunctivitis in Southern Europe. Respir Med. 2007;101:1885–94.View ArticlePubMedGoogle Scholar
- Bachert C, Vestenbaek U, Christensen J, Griffiths UK, Poulsen PB. Cost-effectiveness of grass allergen tablet (GRAZAX®) for the prevention of seasonal grass pollen induced rhinoconjunctivitis—a Northern European perspective. Clin Exp Allergy. 2007;37:772–9.View ArticlePubMedGoogle Scholar
- Armentia A, Carballada F, Carretero P, de Paz S, Lobera T, Marcos C, Martínez JC, Rodríguez I, Soto T, Venturini M, de la Torre F. Postmarketing study for assessment of tolerability of a grass allergen immunotherapy Tablet (GRAZAX®) in patients with rhinitis or rhinoconjunctivitis. J Investig Allergol Clin Immunol. 2012;22:485–90.PubMedGoogle Scholar
- Stewart MA. Effective physician-patient communication and health outcomes: a review. Can Med Assoc J. 1995;152:1423–33.Google Scholar
- Williams S, Weinman J, Dale J. Doctor-patient communication and patient satisfaction: a review. Fam Pract. 1998;15:480–92.View ArticlePubMedGoogle Scholar