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  1. Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in ...

    Authors: Supinda Bunyavanich, Erik Melen, Jemma B Wilk, Mark Granada, Manuel E Soto-Quiros, Lydiana Avila, Jessica Lasky-Su, Gary M Hunninghake, Magnus Wickman, Göran Pershagen, George T O'Connor, Scott T Weiss and Juan C Celedόn
    Citation: Clinical and Molecular Allergy 2011 9:1
    Content type: Research Published on:

  2. Skin prick testing is widely used to predict the presence of allergen-specific IgE. In eosinophilic esophagitis patients, who frequently exhibit polysensitization and broad reactivity upon skin prick testing, ...

    Authors: Toral A Kamdar, Anne M Ditto and Paul J Bryce
    Citation: Clinical and Molecular Allergy 2010 8:16
    Content type: Case Report Published on:

  3. A. fumigatus has been associated with a wide spectrum of allergic disorders such as ABPA or SAFS. It is poorly understood what allergens in particular are being expressed during fungal invasion and which are resp...

    Authors: Marcin G Fraczek, Rifat Rashid, Marian Denson, David W Denning and Paul Bowyer
    Citation: Clinical and Molecular Allergy 2010 8:15
    Content type: Research Published on:

  4. Histamine-metabolizing enzymes (N-methyltransferase and amiloride binding protein 1) are responsible for histamine degradation, a biogenic amine involved in allergic inflammation. Genetic variants of HNMT and ABP...

    Authors: Aleksandra Szczepankiewicz, Anna Bręborowicz, Paulina Sobkowiak and Anna Popiel
    Citation: Clinical and Molecular Allergy 2010 8:14
    Content type: Research Published on:

  5. Flavonoids, a large group of polyphenolic metabolites derived from plants have received a great deal of attention over the last several decades for their properties in inflammation and allergy. Quercetin, the ...

    Authors: Salvatore Chirumbolo, Marta Marzotto, Anita Conforti, Antonio Vella, Riccardo Ortolani and Paolo Bellavite
    Citation: Clinical and Molecular Allergy 2010 8:13
    Content type: Research Published on:

  6. Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN...

    Authors: Haorile Chagan-Yasutan, Beata Shiratori, Umme Ruman Siddiqi, Hiroki Saitoh, Yugo Ashino, Tomohiro Arikawa, Mitsuomi Hirashima and Toshio Hattori
    Citation: Clinical and Molecular Allergy 2010 8:12
    Content type: Case Report Published on:

  7. Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However, the association of allergen-induced cord blood mononuclear cel...

    Authors: Carolyn Chang, Kevin Gauvey-Kern, Alina Johnson, Elizabeth A Kelvin, Ginger L Chew, Frederica Perera and Rachel L Miller
    Citation: Clinical and Molecular Allergy 2010 8:11
    Content type: Research Published on:

  8. Eosinophils are involved in various inflammatory processes including allergic inflammation during which angiogenesis has been documented. Angiogenesis is most likely connected to the hypoxia which characterize...

    Authors: Alon H Nissim Ben Efraim, Ron Eliashar and Francesca Levi-Schaffer
    Citation: Clinical and Molecular Allergy 2010 8:10
    Content type: Research Published on:

  9. The mechanism(s) responsible for the reduced risk of allergic disease in breastfed infants are not fully understood. Using an established murine model of asthma, we demonstrated previously that resistance to a...

    Authors: Adam P Matson, Roger S Thrall, Ektor Rafti, Elizabeth G Lingenheld and Lynn Puddington
    Citation: Clinical and Molecular Allergy 2010 8:9
    Content type: Research Published on:

  10. Atopic dermatitis (AD) is often the prelude to allergic diseases. The aim of this study was 1) to evaluate if an integrated management regime could bring about a change in the evolution of the disease in compa...

    Authors: Giampaolo Ricci, Annalisa Patrizi, Arianna Giannetti, Arianna Dondi, Barbara Bendandi and Massimo Masi
    Citation: Clinical and Molecular Allergy 2010 8:8
    Content type: Research Published on:

  11. Hymenoptera venoms are known to cause life-threatening IgE-mediated anaphylactic reactions in allergic individuals. Proper diagnosis of hymenoptera venom allergy using venom extracts is severely affected by mo...

    Authors: Henning Seismann, Simon Blank, Liliana Cifuentes, Ingke Braren, Reinhard Bredehorst, Thomas Grunwald, Markus Ollert and Edzard Spillner
    Citation: Clinical and Molecular Allergy 2010 8:7
    Content type: Research Published on:

  12. Mannose-binding lectin (MBL) and the Mannose-binding lectin-associated serine proteases (MASPs) are an essential aspect of innate immune responses that probably play an important but understudied role in cutan...

    Authors: Christopher Miller, Sara Wilgenbusch, Mini Michael, David S Chi, George Youngberg and Guha Krishnaswamy
    Citation: Clinical and Molecular Allergy 2010 8:6
    Content type: Review Published on:

  13. Asthma afflicts 6% to 8% of the United States population, and severe asthma represents approximately 10% of asthmatic patients. Several epidemiologic studies in the United States and Europe have linked Alternaria

    Authors: Alan P Knutsen, Hari M Vijay, Barbara Kariuki, Luis A Santiago, Ralph Graff, Jonathan D Wofford and Maulik R Shah
    Citation: Clinical and Molecular Allergy 2010 8:5
    Content type: Research Published on:

  14. Some studies reported the possible induction of food allergy, caused by neo-sensitization to cross-reacting allergens, during immunotherapy with aeroallergens, while other studies ruled out such possibility.

    Authors: Renato E Rossi, Giorgio Monasterolo, Cristoforo Incorvaia, Philippe Moingeon, Franco Frati, Giovanni Passalacqua, Lucilla Rossi and Giorgio W Canonica
    Citation: Clinical and Molecular Allergy 2010 8:4
    Content type: Research Published on:

  15. Altered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecul...

    Authors: Mariah B Pate, John Kelly Smith, David S Chi and Guha Krishnaswamy
    Citation: Clinical and Molecular Allergy 2010 8:3
    Content type: Review Published on:

  16. Subcutaneous Immunotherapy (SCIT) modifies the allergic response and relieves allergic symptoms. SCIT is the only and a very effective treatment for insect venom allergy. We hypothesized that basophil sensitiv...

    Authors: Susan Mikkelsen, Bo Martin Bibby, Mette Konow Bøgebjerg Dolberg, Ronald Dahl and Hans Jürgen Hoffmann
    Citation: Clinical and Molecular Allergy 2010 8:2
    Content type: Research Published on:

  17. Rhinitis is characterized by rhinorrhea, sneezing, nasal congestion, nasal itch and/or postnasal drip. Often the first step in arriving at a diagnosis is to exclude or diagnose sensitivity to inhalant allergen...

    Authors: Cyrus H Nozad, L Madison Michael, D Betty Lew and Christie F Michael
    Citation: Clinical and Molecular Allergy 2010 8:1
    Content type: Review Published on:

  18. Sensitization to Thyreophagus entomophagus, a storage mite, is uncommon and might produce occupational respiratory disorders in farmers. We present the first case of a child suffering anaphylaxis produced by inge...

    Authors: Javier Iglesias-Souto, Inmaculada Sánchez-Machín, Víctor Iraola, Paloma Poza, Ruperto González and Víctor Matheu
    Citation: Clinical and Molecular Allergy 2009 7:10
    Content type: Case Report Published on:

  19. The use of biotechnological techniques to introduce novel proteins into food crops (transgenic or GM crops) has motivated investigation into the properties of proteins that favor their potential to elicit alle...

    Authors: Rod A Herman, Ping Song and Arvind ThirumalaiswamySekhar
    Citation: Clinical and Molecular Allergy 2009 7:9
    Content type: Research Published on:

  20. In the United States, asthma prevalence is particularly high among urban children. Although the underlying immune mechanism contributing to asthma has not been identified, having impaired T regulatory (Treg) c...

    Authors: Ngoc P Ly, Begona Ruiz-Perez, Rachel M McLoughlin, Cynthia M Visness, Paul K Wallace, William W Cruikshank, Arthur O Tzianabos, George T O'Connor, Diane R Gold and James E Gern
    Citation: Clinical and Molecular Allergy 2009 7:8
    Content type: Research Published on:

  21. Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized s...

    Authors: Amrendra Kumar and Balaram Ghosh
    Citation: Clinical and Molecular Allergy 2009 7:7
    Content type: Review Published on:

  24. Though not widely recognized, food hypersensitivity by inhalation can cause major morbidity in affected individuals. The exposure is usually more obvious and often substantial in occupational environments but ...

    Authors: Daniel A Ramirez Jr and Sami L Bahna
    Citation: Clinical and Molecular Allergy 2009 7:4
    Content type: Review Published on:

  25. Bermuda grass (Cynodon dactylon; subfamily Chloridoideae) is an important source of seasonal aeroallergens in warm tropical and sub-tropical areas worldwide. Improved approaches to diagnosis and therapy of allerg...

    Authors: Ruby Tiwari, Prem L Bhalla and Mohan B Singh
    Citation: Clinical and Molecular Allergy 2009 7:3
    Content type: Research Published on:

  26. Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition, recent evidence strongly suggests that viral infections may also have a causal role in the development ...

    Authors: Matthew M Huckabee and R Stokes Peebles Jr
    Citation: Clinical and Molecular Allergy 2009 7:2
    Content type: Review Published on:

  27. Food allergies affect an estimated 3 to 4% of adults and up to 8% of children in developed western countries. Results from in vitro simulated gastric digestion studies with purified proteins are routinely used to...

    Authors: Santiago Schnell and Rod A Herman
    Citation: Clinical and Molecular Allergy 2009 7:1
    Content type: Review Published on:

  28. Hypersensitivity to human seminal fluid is rare but can be life threatening. We report a case of IgE-mediated anaphylaxis to seminal plasma that was diagnosed by skin prick tests and successfully treated by lo...

    Authors: Jaechun Lee, Sohyung Kim, Miok Kim, Young-Bae Chung, Jung-Sik Huh, Chul Min Park, Keun Hwa Lee and Jeong Hong Kim
    Citation: Clinical and Molecular Allergy 2008 6:13
    Content type: Case Report Published on:

  29. Basophils are circulating cells involved in hypersensitivity reactions and allergy but many aspects of their activation, including the sensitivity to external triggering factors and the molecular aspects of ce...

    Authors: Salvatore Chirumbolo, Antonio Vella, Riccardo Ortolani, Marzia De Gironcoli, Pietro Solero, Giuseppe Tridente and Paolo Bellavite
    Citation: Clinical and Molecular Allergy 2008 6:12
    Content type: Research Published on:

  30. A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results.

    Authors: Erick Forno, Andrew B Onderdonk, John McCracken, Augusto A Litonjua, Daniel Laskey, Mary L Delaney, Andrea M DuBois, Diane R Gold, Louise M Ryan, Scott T Weiss and Juan C Celedón
    Citation: Clinical and Molecular Allergy 2008 6:11
    Content type: Research Published on:

  31. Mucosal-based immunotherapy has been already used as an alternative form of allergen delivery. In asthma, the poor success rate of immune modulation could be a consequence of inadequate immune modulation in th...

    Authors: Tahereh Mousavi, Nader Tajik, Maziar Moradi and Masoomeh Fallah Radjabzadeh
    Citation: Clinical and Molecular Allergy 2008 6:10
    Content type: Research Published on:

  33. In the 1920's, Hoover described a sign that could be considered a marker of severe airway obstruction. While readily recognizable at the bedside, it may easily be missed on a cursory physical examination. Hoov...

    Authors: Chambless R Johnston III, Narayanaswamy Krishnaswamy and Guha Krishnaswamy
    Citation: Clinical and Molecular Allergy 2008 6:8
    Content type: Review Published on:

  34. During production of sugar beet (Beta vulgaris) seeds in greenhouses, workers frequently develop allergic symptoms. The aim of this study was to identify and characterize possible allergens in sugar beet pollen.

    Authors: Susanne Luoto, Wietske Lambert, Anna Blomqvist and Cecilia Emanuelsson
    Citation: Clinical and Molecular Allergy 2008 6:7
    Content type: Research Published on:

  35. IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases.

    Authors: Michael Pistiner, Gary M Hunninghake, Manuel E Soto-Quiros, Lydiana Avila, Amy Murphy, Jessica Lasky-Su, Brooke Schuemann, Barbara J Klanderman, Benjamin A Raby and Juan C Celedón
    Citation: Clinical and Molecular Allergy 2008 6:6
    Content type: Research Published on:

  37. Atopic diseases and asthma are increasing at a remarkable rate on a global scale. It is now well recognized that asthma is a chronic inflammatory disease of the airways. The inflammatory process in many patien...

    Authors: Christopher WT Miller, Narayanaswamy Krishnaswamy, Chambless Johnston and Guha Krishnaswamy
    Citation: Clinical and Molecular Allergy 2008 6:4
    Content type: Review Published on:

  40. Commercial available skin prick test with fruits can be negative in sensitized or allergic patients due to a reduction in biological activity during the manufacturing process. Prick-prick tests with fresh food...

    Authors: Ángel Ferrer, Ángel J Huertas, Carlos H Larramendi, Jose L García-Abujeta, Joan Bartra, Jose R Lavín, Carmen Andreu, Juan A Pagán, María A López-Matas, Enrique Fernández-Caldas and Jerónimo Carnés
    Citation: Clinical and Molecular Allergy 2008 6:1
    Content type: Research Published on:

  41. Human mast cells are multifunctional cells capable of a wide variety of inflammatory responses. Baicalein (BAI), isolated from the traditional Chinese herbal medicine Huangqin (Scutellaria baicalensis Georgi), ha...

    Authors: Chia-Jung Hsieh, Kenton Hall, Tuanzhu Ha, Chuanfu Li, Guha Krishnaswamy and David S Chi
    Citation: Clinical and Molecular Allergy 2007 5:5
    Content type: Research Published on:

  44. The prediction of allergen cross-reactivity is currently largely based on linear sequence data, but will soon include 3D information on homology among surface exposed residues. To evaluate procedures for these...

    Authors: Rob C Aalberse
    Citation: Clinical and Molecular Allergy 2007 5:2
    Content type: Commentary Published on:

  45. There has been a worldwide increase in allergy and asthma over the last few decades, particularly in industrially developed nations. This resulted in a renewed interest to understand the pathogenesis of allerg...

    Authors: Viswanath P Kurup, Christy S Barrios, Raghavan Raju, Bryon D Johnson, Michael B Levy and Jordan N Fink
    Citation: Clinical and Molecular Allergy 2007 5:1
    Content type: Research Published on:

  46. The mechanisms for the association between birth by cesarean section and atopy and asthma are largely unknown.

    Authors: Ngoc P Ly, Begoña Ruiz-Pérez, Andrew B Onderdonk, Arthur O Tzianabos, Augusto A Litonjua, Catherine Liang, Daniel Laskey, Mary L Delaney, Andrea M DuBois, Hara Levy, Diane R Gold, Louise M Ryan, Scott T Weiss and Juan C Celedón
    Citation: Clinical and Molecular Allergy 2006 4:13
    Content type: Research Published on:

  47. Entomopathogenic fungi such as Beauveria bassiana are considered promising biological control agents for a variety of arthropod pests. Beauveria species, however, have the potential to elicit allergenic reactions...

    Authors: Greg S Westwood, Shih-Wen Huang and Nemat O Keyhani
    Citation: Clinical and Molecular Allergy 2006 4:12
    Content type: Research Published on:

  48. Aspergillus fumigatus, a widely distributed fungus, has been implicated in causing life threatening infections as well as severe asthma and allergic diseases in man. Allergic affliction like allergic bronchopulmo...

    Authors: Viswanath P Kurup, Alan P Knutsen, Richard B Moss and Naveen K Bansal
    Citation: Clinical and Molecular Allergy 2006 4:11
    Content type: Research Published on:

  49. The potato is one of the most common types of genetically modified (GM) food. However, there are no published data evaluating the impact of genetic manipulations on the allergenicity of GM potatoes. To compare...

    Authors: Soo-Keol Lee, Young-Min Ye, Sung-Ho Yoon, Bou-Oung Lee, Seung-Hyun Kim and Hae-Sim Park
    Citation: Clinical and Molecular Allergy 2006 4:10
    Content type: Research Published on:

  50. Atopy and allergic phenotypes are biologically characterized by an imbalanced T helper cell response skewed towards a type 2 (TH2) immune response associated with elevated serum immunoglobulin E (IgE) levels. ...

    Authors: M Imboden, A Nieters, AJ Bircher, M Brutsche, N Becker, M Wjst, U Ackermann-Liebrich, W Berger and NM Probst-Hensch
    Citation: Clinical and Molecular Allergy 2006 4:9
    Content type: Research Published on:


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