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  1. Content type: Research

    Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physicia...

    Authors: Mizuho Nagao, Magnus P. Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel and Takao Fujisawa

    Citation: Clinical and Molecular Allergy 2017 15:4

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  2. Content type: Case Report

    Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may ...

    Authors: Fabiano Di Marco, Giuseppe Francesco Sferrazza Papa, Dejan Radovanovic and Pierachille Santus

    Citation: Clinical and Molecular Allergy 2017 15:3

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  3. Content type: Review

    Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is pa...

    Authors: Maria Teresa Ventura, Nicola Scichilone, Roberto Paganelli, Paola Lucia Minciullo, Vincenzo Patella, Matteo Bonini, Giovanni Passalacqua, Carlo Lombardi, Livio Simioni, Erminia Ridolo, Stefano R. Del Giacco, Sebastiano Gangemi and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2017 15:2

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  4. Content type: Research

    Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX® is the most documented product in terms of safety and efficacy. T...

    Authors: Tomás Chivato, Pedro Álvarez-Calderón, Carmen Panizo, Ricardo Abengozar, César Alías, Ali Al-Baech, José Arias-Irigoyen, M. José Caballero, Lluis Conill, Silvia de Miguel, Rafael Laguna, Joan Martínez-Benazet, Francisco Matoses, Jose Camilo Martínez-Alonso, Lourdes Mendizábal, Celsa Pérez-Carral…

    Citation: Clinical and Molecular Allergy 2017 15:1

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  5. Content type: Review

    The tapeworm Taenia (T.) solium can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tis...

    Authors: Paola Lucia Minciullo, Antonio Cascio, Stefania Isola and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2016 14:18

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  6. Content type: Review

    Eosinophilic diseases of the gastrointestinal tract, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), are rare chronic pathologies of the digestive system, with an immuno-mediat...

    Authors: Erminia Ridolo, Valerie Melli, Gianluigi De’ Angelis and Irene Martignago

    Citation: Clinical and Molecular Allergy 2016 14:17

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  7. Content type: Research

    CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that ch...

    Authors: Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato and Lorenzo Cosmi

    Citation: Clinical and Molecular Allergy 2016 14:16

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  8. Content type: Research

    The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal enviro...

    Authors: Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Antonio Lobasso, Filomena Napolitano, Francescopaolo Granata, Carmine Selleri and Amato de Paulis

    Citation: Clinical and Molecular Allergy 2016 14:15

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  9. Content type: Case Report

    Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involveme...

    Authors: Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Donatella Sangari, Santa Cirmi, Roneka L. Ravenell, Michele Navarra, Gianfilippo Bagnato and Sebastiano Gangemi

    Citation: Clinical and Molecular Allergy 2016 14:13

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  10. Content type: Review

    This meta-analysis compared the health-related quality of life (HRQL) of patients with allergic rhinitis (AR) and/or allergic asthma (AA) caused by perennial house dust mite (HDM) versus AR and/or AA caused by...

    Authors: A. Linneberg, K. Dam Petersen, J. Hahn-Pedersen, E. Hammerby, N. Serup-Hansen and N. Boxall

    Citation: Clinical and Molecular Allergy 2016 14:12

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  11. Content type: Review

    Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of different effectors mechanisms of the immune system, namely antibodies and T cells. Their occurrence may be associated with...

    Authors: Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Paola Parronchi and Sergio Romagnani

    Citation: Clinical and Molecular Allergy 2016 14:11

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  12. Content type: Review

    The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the...

    Authors: Paola Lucia Minciullo, Giovanni Paolino, Maddalena Vacca, Sebastiano Gangemi and Eustachio Nettis

    Citation: Clinical and Molecular Allergy 2016 14:10

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  13. Content type: Review

    Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multi...

    Authors: Mona-Rita Yacoub, Alvise Berti, Corrado Campochiaro, Enrico Tombetti, Giuseppe Alvise Ramirez, Andrea Nico, Elisabetta Di Leo, Paola Fantini, Maria Grazia Sabbadini, Eustachio Nettis and Giselda Colombo

    Citation: Clinical and Molecular Allergy 2016 14:9

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  14. Content type: Research

    Children with atopic dermatitis (AD) are at risk of developing allergy. Alongside clinical history, testing modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) and recently, microarra...

    Authors: Ru-Xin Foong, Graham Roberts, Adam Tobias Fox and George du Toit

    Citation: Clinical and Molecular Allergy 2016 14:8

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  15. Content type: Research

    Airborne allergens can induce an immunological chronic disease characterized by airway hyper responsiveness and inflammation, mediated by exaggerated Th2 immune response. Allergen-specific immunotherapy (AIT) ...

    Authors: Claudia Petrarca, Emanuela Clemente, Valentina Amato, Alessia Gatta, Sara Cortese, Alessia Lamolinara, Cosmo Rossi, Stefania Zanotta, Gianni Mistrello, Roberto Paganelli and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2016 14:7

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  16. Content type: Review

    Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the presence of antiphospholipid antibodies (aPL) in subjects presenting with thrombosis and/or pregnancy loss. The currently used cl...

    Authors: Savino Sciascia, Simone Baldovino, Karen Schreiber, Laura Solfietti, Massimo Radin, Maria J. Cuadrado, Elisa Menegatti, Doruk Erkan and Dario Roccatello

    Citation: Clinical and Molecular Allergy 2016 14:6

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  17. Content type: Commentary

    In a historical period in which sustainability of the National Health Service is mandatory because of the international economical situation, the limited available resources at national level and the tendency ...

    Authors: Carlo Lombardi, Eleonora Savi, Maria Teresa Costantino, Enrico Heffler, Manlio Milanese, Giovanni Passalacqua and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2016 14:5

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  18. Content type: Review

    Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in t...

    Authors: Darío Antolín-Amérigo, Luis Manso, Marco Caminati, Belén de la Hoz Caballer, Inmaculada Cerecedo, Alfonso Muriel, Mercedes Rodríguez-Rodríguez, José Barbarroja-Escudero, María José Sánchez-González, Beatriz Huertas-Barbudo and Melchor Alvarez-Mon

    Citation: Clinical and Molecular Allergy 2016 14:4

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  19. Content type: Research

    Cross-reactivity among Hymenoptera venoms is an important issue when prescribing venom immunotherapy (VIT). Using all venoms eliciting a positive response results in treatment excess and unjustified cost incre...

    Authors: Eleonora Savi, Silvia Peveri, Elena Makri, Valerio Pravettoni and Cristoforo Incorvaia

    Citation: Clinical and Molecular Allergy 2016 14:3

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  20. Content type: Research

    Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria ...

    Authors: Lorenzo Drago, Roberta De Grandi, Gianfranco Altomare, Paolo Pigatto, Oliviero Rossi and Marco Toscano

    Citation: Clinical and Molecular Allergy 2016 14:2

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  21. Content type: Research

    Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involv...

    Authors: Letizia Lombardelli, Federica Logiodice, Maryse Aguerre-Girr, Ornela Kullolli, Herman Haller, Ysabel Casart, Alain Berrebi, Fatima-Ezzahra L’Faqihi-Olive, Valérie Duplan, Sergio Romagnani, Enrico Maggi, Daniel Rukavina, Philippe Le Bouteiller and Marie-Pierre Piccinni

    Citation: Clinical and Molecular Allergy 2016 14:1

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  22. Content type: Erratum

    Authors: Donatella Macchia, Giovanni Melioli, Valerio Pravettoni, Eleonora Nucera, Marta Piantanida, Marco Caminati, Corrado Campochiaro, Mona-Rita Yacoub, Domenico Schiavino, Roberto Paganelli and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2015 13:31

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    The original article was published in Clinical and Molecular Allergy 2015 13:27

  23. Content type: Research

    Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE ch...

    Authors: Valerio Pravettoni, Marta Piantanida, Laura Primavesi, Stella Forti and Elide A. Pastorello

    Citation: Clinical and Molecular Allergy 2015 13:29

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  24. Content type: Research

    In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlat...

    Authors: Carina Gabriela Uasuf, Danilo Villalta, Maria Elisabetta Conte, Caterina Di Sano, Maria Barrale, Vincenzo Cantisano, Elisabetta Pace, Mark Gjomarkaj, Sebastiano Gangemi and Ignazio Brusca

    Citation: Clinical and Molecular Allergy 2015 13:30

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  25. Content type: Research

    One of the main problem health care systems are facis is the mis-use and over-use of medical resources (including useless exams, surgical interventions, medical treatments, screening procedures…) which may lea...

    Authors: Enrico Heffler, Massimo Landi, Silvana Quadrino, Cristoforo Incorvaia, Stefano Pizzimenti, Sandra Vernero, Nunzio Crimi, Giovanni Rolla and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2015 13:28

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  26. Content type: Research

    Published data suggest that asthma is significantly under/misdiagnosed. The present community-based study performed in Italy aims at investigating the level of asthma under/misdiagnosis among patients referrin...

    Authors: Maria Sandra Magnoni, Marco Caminati, Gianenrico Senna, Fabio Arpinelli, Andrea Rizzi, Anna Rita Dama, Michele Schiappoli, Germano Bettoncelli and Gaetano Caramori

    Citation: Clinical and Molecular Allergy 2015 13:26

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  27. Content type: Review

    Clinically amyopathic dermatomyositis (CADM), described almost 50 years ago, is defined on the basis of still not validated criteria and characterized by skin findings almost without muscle weakness. Autoantib...

    Authors: Paola Parronchi, Anna Radice, Boaz Palterer, Francesco Liotta and Cristina Scaletti

    Citation: Clinical and Molecular Allergy 2015 13:22

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  28. Content type: Research

    In the few studies available, the risk of developing systemic reactions (SR) to hymenoptera stings in patients with previous large local reactions (LLRs) to stings ranges from 0 to 7 %. We evaluated both retro...

    Authors: Stefano Pucci, Simona D’Alò, Tiziana De Pasquale, Ilenia Illuminati, Elena Makri and Cristoforo Incorvaia

    Citation: Clinical and Molecular Allergy 2015 13:21

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  29. Content type: Research

    General practitioners (GPs), community pharmacists and allergic rhinitis (AR) patients in Italy were surveyed in order to gain insight from all three perspectives into the diagnosis, management and burden of A...

    Authors: G. Walter Canonica, Massimo Triggiani and GianEnrico Senna

    Citation: Clinical and Molecular Allergy 2015 13:25

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  30. Content type: Review

    Food allergy has an increasing prevalence in the general population and in Italy concerns 8 % of people with allergies. The spectrum of its clinical manifestations ranges from mild symptoms up to potentially f...

    Authors: Donatella Macchia, Giovanni Melioli, Valerio Pravettoni, Eleonora Nucera, Marta Piantanida, Marco Caminati, Corrado Campochiaro, Mona-Rita Yacoub, Domenico Schiavino, Roberto Paganelli and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2015 13:27

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    The Erratum to this article has been published in Clinical and Molecular Allergy 2015 13:31

  31. Content type: Review

    Severe asthma (SA) is a clinically and etiologically heterogeneous respiratory disease which affects among 5–10 % of asthmatic patients. Despite high-dose therapy, a large patients percentage is not fully cont...

    Authors: Alessandra Chiappori, Laura De Ferrari, Chiara Folli, Pierluigi Mauri, Anna Maria Riccio and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2015 13:20

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  32. Content type: Research

    The aetiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is still unknown. The role of atopy and the concept of united airways in such patients are still a matter of debate. In this pilot stu...

    Authors: Mona-Rita Yacoub, Matteo Trimarchi, George Cremona, Sara Dal Farra, Giuseppe Alvise Ramirez, Valentina Canti, Emanuel Della Torre, Mattia Baldini, Patrizia Pignatti, Mario Bussi, Maria Grazia Sabbadini, Angelo A Manfredi and Giselda Colombo

    Citation: Clinical and Molecular Allergy 2015 13:23

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  33. Content type: Case Report

    Sarcoidosis is a granulomatous disease whose outcome varies from spontaneous remission to chronic refractory disease. Provided that steroids represent the gold standard as a first line treatment, many immune s...

    Authors: Francesco Cinetto, Nicolò Compagno, Riccardo Scarpa, Giacomo Malipiero and Carlo Agostini

    Citation: Clinical and Molecular Allergy 2015 13:19

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  34. Content type: Review

    Rhinitis is often the first symptom of allergy but is frequently ignored and classified as a nuisance condition. Ironically it has the greatest socioeconomic burden worldwide caused by its impact on work and o...

    Authors: Oliviero Rossi, Ilaria Massaro, Marco Caminati, Cristina Quecchia, Filippo Fassio, Enrico Heffler and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2015 13:17

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  35. Content type: Research

    TNF-like ligand 1A (TL1A), a recently recognized member of the TNF superfamily, and its death domain receptor 3 (DR3), firstly identified for their relevant role in T lymphocyte homeostasis, are now well-known...

    Authors: M. Facco, A. Cabrelle, F. Calabrese, A. Teramo, F. Cinetto, S. Carraro, V. Martini, F. Calzetti, N. Tamassia, M. A. Cassatella, G. Semenzato and C. Agostini

    Citation: Clinical and Molecular Allergy 2015 13:16

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  36. Content type: Research

    Allergic respiratory diseases are constantly increasing in prevalence. Allergen Immunotherapy (AIT) represent a valuable therapeutic tool as symptomatic and preventative approach, expecially in children. In It...

    Authors: Massimo Landi, Paolo Meglio, Ermanno Praitano, Carlo Lombardi, Giovanni Passalacqua and Giorgio Walter Canonica

    Citation: Clinical and Molecular Allergy 2015 13:15

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  37. Content type: Research

    Crohn’s disease (CD) and Hidradenitis suppurativa (HS) are both chronic inflammatory diseases. The pathogenesis of these diseases is multifactorial, due to the interaction of genetic and environmental factors ...

    Authors: Francesco Giudici, Laura Maggi, Raffaella Santi, Lorenzo Cosmi, Cristina Scaletti, Francesco Annunziato, Gabriella Nesi, Giusi Barra, Gabrio Bassotti, Raffaele De Palma and Francesco Tonelli

    Citation: Clinical and Molecular Allergy 2015 13:12

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  38. Content type: Review

    Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used in a large number of applications including medical (for diagnostic and therapeutic purposes). Once inside the ...

    Authors: Claudia Petrarca, Emanuela Clemente, Valentina Amato, Paola Pedata, Enrico Sabbioni, Giovanni Bernardini, Ivo Iavicoli, Sara Cortese, Qiao Niu, Takemi Otsuki, Roberto Paganelli and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2015 13:13

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  39. Content type: Research

    We designed the PROXIMA study (Patient-Reported Outcomes and Xolair® In the Management of Asthma) to determine the proportion of patients with severe asthma sensitive to perennial allergens, and to evaluate asthm...

    Authors: Giorgio Walter Canonica, Marta Bartezaghi, Raffaele Marino and Laura Rigoni

    Citation: Clinical and Molecular Allergy 2015 13:10

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  40. Content type: Research

    Hypersensitivity reactions to anaesthetic agents are rare but often severe, with a mortality ranging from 4 to 9% in IgE-mediated events. Identification of the risk factors may contribute to limit the incidenc...

    Authors: Corrado Mirone, Donatella Preziosi, Ambra Mascheri, Gianluigi Micarelli, Laura Farioli, Luca G Balossi, Joseph Scibilia, Jan Schroeder, Laura M Losappio, Maria G Aversano, Chrysi Stafylaraki, Michele Nichelatti and Elide A Pastorello

    Citation: Clinical and Molecular Allergy 2015 13:11

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  41. Content type: Review

    The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a com...

    Authors: Nicola Scichilone, Maria T Ventura, Matteo Bonini, Fulvio Braido, Caterina Bucca, Marco Caminati, Stefano Del Giacco, Enrico Heffler, Carlo Lombardi, Andrea Matucci, Manlio Milanese, Roberto Paganelli, Giovanni Passalacqua, Vincenzo Patella, Erminia Ridolo, Giovanni Rolla…

    Citation: Clinical and Molecular Allergy 2015 13:7

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  42. Content type: Review

    Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release vario...

    Authors: Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Sergio Romagnani and Philippe Le Bouteiller

    Citation: Clinical and Molecular Allergy 2015 13:9

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  43. Content type: Research

    One of the greatest challenges in cardiovascular medicine is to define the best tools for performing an accurate risk stratification for the recurrence of ischemic events in acute coronary syndrome (ACS) patie...

    Authors: Elide Anna Pastorello, Laura Farioli, Laura Michelina Losappio, Nuccia Morici, Matteo Di Biase, Michele Nichelatti, Jan Walter Schroeder, Luca Balossi and Silvio Klugmann

    Citation: Clinical and Molecular Allergy 2015 13:14

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  44. Content type: Review

    Despite the use of antibiotics and vaccines, the frequency of respiratory tract infections is still high and these infections interest a wide range of patients, from children to aged people, including in parti...

    Authors: Beatrice E Ferrario, Silvia Garuti, Fulvio Braido and Giorgio W Canonica

    Citation: Clinical and Molecular Allergy 2015 13:8

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  45. Content type: Research

    In the latest decades, epidemiological studies on allergic disorders in children, including atopic dermatitis, rhinitis and asthma, demonstrated a continuous increase in prevalence. However, such studies are u...

    Authors: Nicola Fuiano, Giuliana Diddi, Maurizio Delvecchio and Cristoforo Incorvaia C

    Citation: Clinical and Molecular Allergy 2015 13:2

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    The Erratum to this article has been published in Clinical and Molecular Allergy 2015 13:18

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