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  1. Tranexamic acid (TXA) is a synthetic lysine analogue that is well known as antifibrinolytic agent. It can reduce blood loss in clinical use, especially in conditions where fibrinolysis or hyperfibrinolysis are...

    Authors: Giuseppe Murdaca, Monica Greco, Chiara Vassallo and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2020 18:16
    Content type: Review Published on:

  2. Asthma affects up to nearly 40% of patients with allergic rhinitis (AR). Poor control of AR symptoms is associated with poor asthma control. The goal of this study was to evaluate the effect of AR treatment wi...

    Authors: David Price, Ludger Klimek, Gabriella Gálffy, Melanie Emmeluth, Arkady Koltun, Ferdinand Kopietz, Duc Tung Nguyen, Ranny van Weissenbruch, Wolfgang Pohl, Hans-Christian Kuhl, Glenis Scadding and Joaquim Mullol
    Citation: Clinical and Molecular Allergy 2020 18:15
    Content type: Research Published on:

  3. COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50–69 years age group, an unfavourable factor. Females are constitutionally prone t...

    Authors: Lorenzo Salvati, Benedetta Biagioni, Emanuele Vivarelli and Paola Parronchi
    Citation: Clinical and Molecular Allergy 2020 18:14
    Content type: Review Published on:

  4. Hypersensitivity reactions (HRs) to contrast media (CM) can be distinguished in immune-mediated (including allergic reactions) and non-immune-mediated reactions, even if clinical manifestations could be simila...

    Authors: Maria Teresa Costantino, Laura Romanini, Francesco Gaeta, Fulvio Stacul, Rocco Luigi Valluzzi, Matteo Passamonti, Patrizia Bonadonna, Giovanni Cerri, Stefano Pucci, Paolo Ricci, Eleonora Savi, Michele Galluzzo, Marina Mauro, Emanuele Grassedonio, Mona Rita Yacoub, Alfonso Reginelli…
    Citation: Clinical and Molecular Allergy 2020 18:13
    Content type: Review Published on:

  5. COVID-19, the novel coronavirus affecting the most part of worldwide countries since early 2020, is fast increasing its prevalence around the world, representing a significant emergency for the population and ...

    Authors: Sebastiano Gangemi, Lucia Billeci and Alessandro Tonacci
    Citation: Clinical and Molecular Allergy 2020 18:12
    Content type: Correspondence Published on:

  6. Sensitization to peanuts and hazelnuts is common among young asthmatics and can be primary or a result of cross-reactivity. Sensitization as a result of cross-reactivity to birch pollen is typically associated...

    Authors: Jennifer Johnson, Andrei Malinovschi, Jonas Lidholm, Carl Johan Petersson, Lennart Nordvall, Christer Janson, Kjell Alving and Magnus P. Borres
    Citation: Clinical and Molecular Allergy 2020 18:11
    Content type: Research Published on:

  7. House-dust mites (HDM) allergy is the prevailing condition in subjects allergic to inhalants. Clinical studies with HDM extracts—either subcutaneous (SCIT) or sublingual (SLIT) have long been characterized by ...

    Authors: Gianfranco Vitiello, Lucia Maltagliati and Oliviero Rossi
    Citation: Clinical and Molecular Allergy 2020 18:10
    Content type: Review Published on:

  9. Urticaria is a disorder affecting skin and mucosal tissues characterized by the occurrence of wheals, angioedema or both, the latter defining the urticaria-angioedema syndrome. It is estimated that 12–22% of t...

    Authors: Eustachio Nettis, Caterina Foti, Marina Ambrifi, Ilaria Baiardini, Leonardo Bianchi, Alessandro Borghi, Marco Caminati, Giorgio Walter Canonica, Marco Casciaro, Laura Colli, Giselda Colombo, Monica Corazza, Antonio Cristaudo, Giulia De Feo, Ornella De Pita’, Mario Di Gioacchino…
    Citation: Clinical and Molecular Allergy 2020 18:8
    Content type: Review Published on:

  10. Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma r...

    Authors: Alireza Sharif, Hamed Haddad Kashani and Mohammad Reza Sharif
    Citation: Clinical and Molecular Allergy 2020 18:7
    Content type: Research Published on:

  14. Fingolimod, an immunomodulatory agent, is used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Fingolimod-associated macular edema (FAME) is a known complication with an incidence of 0.4%. ...

    Authors: Rachel Husmann, John B. Davies, Malik Ghannam, Brent Berry and Praful Kelkar
    Citation: Clinical and Molecular Allergy 2020 18:3
    Content type: Case Report Published on:

  15. Cetirizine is a second-generation antihistamine, derived from the metabolism of hydroxyzine, highly specific for the H1 receptors, and with marked antiallergic properties. Although its history began more than ...

    Authors: Giuseppe Fabio Parisi, Salvatore Leonardi, Giorgio Ciprandi, Angelo Corsico, Amelia Licari, Michele Miraglia del Giudice, Diego Peroni, Carmelo Salpietro and Gian Luigi Marseglia
    Citation: Clinical and Molecular Allergy 2020 18:2
    Content type: Review Published on:

  16. Mulberry is a plant belonging to the family Moraceae, and genus Morus. Allergic sensitization to mulberries has been reported as both food allergy or respiratory allergy, and cross-reactivity between mulberries a...

    Authors: F. Papia, C. Incorvaia, L. Genovese, S. Gangemi and P. L. Minciullo
    Citation: Clinical and Molecular Allergy 2020 18:1
    Content type: Review Published on:

  17. Allergic diseases are among major pediatric issues as they are highly prevalent and chronic. Therefore, identification of factors contributing to allergic disease could play a significant role in prevention of...

    Authors: Iraj Mohammadzadeh, Mohsen Haghshenas, Samaneh Asefi and Reza Alizadeh-Navaei
    Citation: Clinical and Molecular Allergy 2019 17:11
    Content type: Research Published on:

  18. The aim of this study was to determine if the inflammation of the sympathetic ganglia (SG) in thromboangiitis obliterans (TAO) is induced by an infectious pathogen inside or if it is a reactive sterile inflamm...

    Authors: Behzad Mousazadeh, Hiva Sharebiani, Hossein Taheri, Narges Valizedeh and Bahare Fazeli
    Citation: Clinical and Molecular Allergy 2019 17:10
    Content type: Research Published on:

  19. Common variable immunodeficiency (CVID) is the most frequent symptomatic primary antibody deficiency in adulthood and is characterized by the marked reduction of IgG and IgA serum levels. Thanks to the success...

    Authors: Antonio Pecoraro, Ludovica Crescenzi, Maria Rosaria Galdiero, Giancarlo Marone, Felice Rivellese, Francesca Wanda Rossi, Amato de Paulis, Arturo Genovese and Giuseppe Spadaro
    Citation: Clinical and Molecular Allergy 2019 17:9
    Content type: Review Published on:

  20. Component-resolved diagnosis (CRD) allows to identify single molecular allergen components, and constitutes a routine practice in many allergy units. However, skin prick test (SPT) remains the technique of cho...

    Authors: Guillermo Til-Pérez, Claudio Carnevale, Pedro Luis Sarría-Echegaray, Diego Arancibia-Tagle, Sendy Chugo-Gordillo and Manuel David Tomás-Barberán
    Citation: Clinical and Molecular Allergy 2019 17:8
    Content type: Research Published on:

  21. Improving the safety of subcutaneous immunotherapy (SCIT) for food allergy is necessary to reduce side effects and achieve long-term tolerance. We determined the effect of dietary supplementation with 1% non-d...

    Authors: Laura Wagenaar, Manon van Roest, Laura J. W. Kruijssen, Peter J. Simons, Louis Boon, Marlotte M. Vonk, Betty C. A. M. van Esch, Leon M. J. Knippels, Johan Garssen, Raymond H. H. Pieters and Joost J. Smit
    Citation: Clinical and Molecular Allergy 2019 17:7
    Content type: Research Published on:

  22. There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is foun...

    Authors: Therese Sterner, Ada Uldahl, Åke Svensson, Magnus P. Borres, Sigrid Sjölander, Alf Tunsäter, Jonas Björk, Cecilia Svedman, Magnus Bruze, Laura von Kobyletzki and Hampus Kiotseridis
    Citation: Clinical and Molecular Allergy 2019 17:6
    Content type: Research Published on:

  23. Atopic dermatitis is a chronic inflammatory skin disorder, whose symptoms and severity grossly depend on individual trigger factors. The majority of patients are satisfactorily treated with emollients together...

    Authors: Susanna Bormioli, Andrea Matucci, Laura Dies, Francesca Nencini, Francesca Grosso, Enrico Maggi and Alessandra Vultaggio
    Citation: Clinical and Molecular Allergy 2019 17:5
    Content type: Case Report Published on:

  24. GST belongs to a super family of phase II detoxification enzyme and it plays an important role in preventing the damage that may occur due to reactive water-soluble compounds generated by the association of re...

    Authors: Israa Hussein Hamzah, Farha A. Ali Shafi, Sahar A. H. Al Sharqi and Suaad Almas Brakhas
    Citation: Clinical and Molecular Allergy 2019 17:4
    Content type: Research Published on:

  25. Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently presents with dysfunction or loss of the sense of smell, resulting in a significant impairment in quality of life. The medical treatments currently ...

    Authors: Carlo Cavaliere, Cristoforo Incorvaia, Franco Frati, Daniela Messineo, Mario Ciotti, Antonio Greco, Marco de Vincentiis and Simonetta Masieri
    Citation: Clinical and Molecular Allergy 2019 17:3
    Content type: Case Report Published on:

  26. A growing use of complementary alternative medicine (CAM) has been found in Europe as well in Italy for chronic diseases, including the allergic rhinitis. The study aims at investigating the prevalence and the...

    Authors: G. Bonizzoni, M. Caminati, E. Ridolo, M. Landi, M. T. Ventura, C. Lombardi, G. Senna, M. Crivellaro and F. Gani
    Citation: Clinical and Molecular Allergy 2019 17:2
    Content type: Research Published on:

  27. Proton pump inhibitors (PPIs) are drugs capable of blocking the gastric pump H,K-ATPase in order to inhibit gastric acid secretion. Omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole belong t...

    Authors: Marco Casciaro, Michele Navarra, Giuseppina Inferrera, Marta Liotta, Sebastiano Gangemi and Paola Lucia Minciullo
    Citation: Clinical and Molecular Allergy 2019 17:1
    Content type: Research Published on:

  28. According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma.

    Authors: Federica Novelli, Elena Bacci, Manuela Latorre, Veronica Seccia, Maria Laura Bartoli, Silvana Cianchetti, Federico Lorenzo Dente, Antonella Di Franco, Alessandro Celi and Pierluigi Paggiaro
    Citation: Clinical and Molecular Allergy 2018 16:25
    Content type: Research Published on:

  29. Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized.

    Authors: Gino A. Vena, Nicoletta Cassano, E. Di Leo, G. F. Calogiuri and Eustachio Nettis
    Citation: Clinical and Molecular Allergy 2018 16:24
    Content type: Review Published on:

  30. Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggri...

    Authors: Zafar Rasheed, Khaled Zedan, Ghada Bin Saif, Ragaa H. Salama, Tarek Salem, Ahmed A. Ahmed, Alaa Abd El-Moniem, Maha Elkholy, Ahmad A. Al Robaee and Abdullateef A. Alzolibani
    Citation: Clinical and Molecular Allergy 2018 16:23
    Content type: Research Published on:

  31. Brentuximab vedotin (BV) is an antibody–drug conjugate formed by an anti-CD30 chimeric IgG1 conjugated with monomethyl-auristatin-E. BV targets the CD30+ cells, which characterize Hodgkin lymphoma as well as anap...

    Authors: Attilio Di Girolamo, Marcello Albanesi, Alessandro Sinisi, Eustachio Nettis, Danilo Di Bona, Maria Filomena Caiaffa and Luigi Macchia
    Citation: Clinical and Molecular Allergy 2018 16:22
    Content type: Case Report Published on:

  32. Kounis syndrome (KS) has been described as the coincidental occurrence of acute coronary syndromes during an allergic reaction with cardiac anaphylaxis. It is caused by inflammatory mediators released after ex...

    Authors: Luisa Ricciardi, Fabiana Furci, Marco Casciaro, Eleonora Di Salvo, Mariateresa Cristani, Valeria Tigano, Paola Lucia Minciullo and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2018 16:21
    Content type: Case Report Published on:

  33. According to the World Health Organization, air pollution is closely associated with climate change and, in particular, with global warming. In addition to melting of ice and snow, rising sea level, and floodi...

    Authors: Vincenzo Patella, Giovanni Florio, Diomira Magliacane, Ada Giuliano, Maria Angiola Crivellaro, Daniela Di Bartolomeo, Arturo Genovese, Mario Palmieri, Amedeo Postiglione, Erminia Ridolo, Cristina Scaletti, Maria Teresa Ventura and Anna Zollo
    Citation: Clinical and Molecular Allergy 2018 16:20
    Content type: Review Published on:

  34. New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our stud...

    Authors: Stefania Isola, Fabiana Furci and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2018 16:19
    Content type: Case Report Published on:

  36. Severe aortic valve stenosis is one of the most common cause of mortality in adult patients affected with metabolic syndrome, a condition associated with an active inflammatory process involving also mast cell...

    Authors: Laura M. Losappio, Corrado Mirone, Michel Chevallard, Laura Farioli, Fabrizio De Luca and Elide A. Pastorello
    Citation: Clinical and Molecular Allergy 2018 16:17
    Content type: Case Report Published on:

  39. Sublingual immunotherapy (SLIT) is effective, tolerable, and convenient for many allergic patients. Still, real-world evidence is scarce and the aim of this study is to assess the patient reported outcome of t...

    Authors: Christer Janson, Fredrik Sundbom, Peter Arvidsson and Mary Kämpe
    Citation: Clinical and Molecular Allergy 2018 16:14
    Content type: Research Published on:

  40. Allergic asthma is an inflammatory disorder of the airways that results from inappropriate production of IgE against harmless, environmental antigens. Sequestration of free IgE using humanized IgG anti-IgE is ...

    Authors: Sonali J. Bracken, Alexander J. Adami, Ektor Rafti, Craig M. Schramm and Adam P. Matson
    Citation: Clinical and Molecular Allergy 2018 16:13
    Content type: Correspondence Published on:

  41. Based on meta-analyses results, it is currently acknowledged that there is an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) undergoing inhaled corticosteroids (ICS) ...

    Authors: Erminia Ridolo, Cristoforo Incorvaia, Irene Martignago, Laura Pessina, Fulvio Lauretani, Luciano Loperfido, Gian Galeazzo Riario-Sforza, Annalisa Broglia, Bruna L. Gritti and Lorenzo Panella
    Citation: Clinical and Molecular Allergy 2018 16:12
    Content type: Research Published on:

  42. Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes,...

    Authors: Marco Casciaro, Eleonora Di Salvo, Teresa Brizzi, Carmelo Rodolico and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2018 16:11
    Content type: Review Published on:

  43. Hymenoptera sting reactions are among life-threatening causes of allergy. Several epidemiology studies have assessed the risk of these kind of reactions, among the general population, around 3% of adults. This...

    Authors: Luisa Ricciardi, Francesco Papia, Giuseppe Cataldo, Mario Giorgianni, Giovanna Spatari and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2018 16:8
    Content type: Research Published on:

  44. Parasite infections stimulate total and specific IgE production that, in the case of Toxocara canis infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar sympt...

    Authors: Rosanna Qualizza, Laura M Losappio and Fabiana Furci
    Citation: Clinical and Molecular Allergy 2018 16:10
    Content type: Case report Published on:

  46. The use of drugs in the elderly is very extensive because of the frequent occurrence of chronic diseases. Adverse drug reactions (ADRs) commonly occur in geriatric patients receiving multiple therapeutic regim...

    Authors: Maria Teresa Ventura, Elisa Boni, Rosa Cecere, Rosalba Buquicchio, Gian Franco Calogiuri, Irene Martignago, Cristoforo Incorvaia and Erminia Ridolo
    Citation: Clinical and Molecular Allergy 2018 16:7
    Content type: Research Published on:

  47. Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been includ...

    Authors: Boaz Palterer, Gianfranco Vitiello, Alessia Carraresi, Maria Grazia Giudizi, Daniele Cammelli and Paola Parronchi
    Citation: Clinical and Molecular Allergy 2018 16:5
    Content type: Review Published on:

  48. Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the prog...

    Authors: Matteo Ferrando, Francesca Racca, Lorena Nascimento Girardi Madeira, Enrico Heffler, Giovanni Passalacqua, Francesca Puggioni, Niccolò Stomeo and Giorgio Walter Canonica
    Citation: Clinical and Molecular Allergy 2018 16:6
    Content type: Review Published on:

  49. Allergic Rhinitis (AR) is a high-prevalence disease. In Europe about 25% of the general population is affected, and in Italy the prevalence is estimated to be 19.8%. The Allergic Rhinitis and its Impact on Ast...

    Authors: Federica Gani, Carlo Lombardi, Laura Barrocu, Massimo Landi, Erminia Ridolo, Massimo Bugiani, Giovanni Rolla, Gianenrico Senna and Giovanni Passalacqua
    Citation: Clinical and Molecular Allergy 2018 16:4
    Content type: Research Published on:

  50. The query “are there animals at home?” is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studi...

    Authors: G. Liccardi, L. Calzetta, G. Baldi, A. Berra, L. Billeri, M. Caminati, P. Capano, E. Carpentieri, A. Ciccarelli, M. A. Crivellaro, M. Cutajar, M. D’Amato, I. Folletti, F. Gani, D. Gargano, D. Giannattasio…
    Citation: Clinical and Molecular Allergy 2018 16:3
    Content type: Research Published on:


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