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Clinical Immunology

Section edited by Massimo Triggiani

  1. Allergic rhinitis is a widespread disorder across the globe. The Shirazi thyme (Zataria multiflora) has been shown to have considerable antioxidant and anti-inflammatory properties. This study assessed the effect...

    Authors: Nazila Ariaee, Yaser Yadegari, Mohamad Shabestari, Javad Asili, Maryam Panahi, Jalal Ghorbani and Farahzad Jabbari
    Citation: Clinical and Molecular Allergy 2022 20:3
    Content type: Research Published on:

  3. Interleukin-33 (IL-33) is a 30KDa protein, which belongs to the Interleukin-1 cytokine family. It is a crucial regulator of innate and adaptive immune responses. This interleukin is additionally involved in th...

    Authors: Eleonora Di Salvo, Marco Casciaro and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:18
    Content type: Letters to the Editor Published on:

  4. Pruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediato...

    Authors: Eleonora Di Salvo, Alessandro Allegra, Marco Casciaro and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2021 19:8
    Content type: Review Published on:

  5. Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease. Few states in developing countries have an adequate management of HAE, but none of them belongs to the former USSR area. Thi...

    Authors: Irina Guryanova, Chiara Suffritti, Debora Parolin, Andrea Zanichelli, Nastassia Ishchanka, Ekaterina Polyakova, Mikhail Belevtsev, Francesca Perego, Marco Cicardi, Yulia Zharankova, Natalya Konoplya, Sonia Caccia and Antonio Gidaro
    Citation: Clinical and Molecular Allergy 2021 19:3
    Content type: Research Published on:

  7. The pandemic COVID-19 abruptly exploded, taking most health professionals around the world unprepared. Italy, the first European country to be hit violently, was forced to activate the lockdown in mid-February...

    Authors: Vincenzo Patella, Gabriele Delfino, Giovanni Florio, Giuseppe Spadaro, Fulvia Chieco Bianchi, Gianerico Senna and Mario Di Gioacchino
    Citation: Clinical and Molecular Allergy 2020 18:18
    Content type: Review Published on:

  8. COVID-19, the novel coronavirus affecting the most part of worldwide countries since early 2020, is fast increasing its prevalence around the world, representing a significant emergency for the population and ...

    Authors: Sebastiano Gangemi, Lucia Billeci and Alessandro Tonacci
    Citation: Clinical and Molecular Allergy 2020 18:12
    Content type: Correspondence Published on:

  10. Fingolimod, an immunomodulatory agent, is used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Fingolimod-associated macular edema (FAME) is a known complication with an incidence of 0.4%. ...

    Authors: Rachel Husmann, John B. Davies, Malik Ghannam, Brent Berry and Praful Kelkar
    Citation: Clinical and Molecular Allergy 2020 18:3
    Content type: Case Report Published on:

  11. Allergic diseases are among major pediatric issues as they are highly prevalent and chronic. Therefore, identification of factors contributing to allergic disease could play a significant role in prevention of...

    Authors: Iraj Mohammadzadeh, Mohsen Haghshenas, Samaneh Asefi and Reza Alizadeh-Navaei
    Citation: Clinical and Molecular Allergy 2019 17:11
    Content type: Research Published on:

  12. The aim of this study was to determine if the inflammation of the sympathetic ganglia (SG) in thromboangiitis obliterans (TAO) is induced by an infectious pathogen inside or if it is a reactive sterile inflamm...

    Authors: Behzad Mousazadeh, Hiva Sharebiani, Hossein Taheri, Narges Valizedeh and Bahare Fazeli
    Citation: Clinical and Molecular Allergy 2019 17:10
    Content type: Research Published on:

  13. Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes,...

    Authors: Marco Casciaro, Eleonora Di Salvo, Teresa Brizzi, Carmelo Rodolico and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2018 16:11
    Content type: Review Published on:

  14. Parasite infections stimulate total and specific IgE production that, in the case of Toxocara canis infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar sympt...

    Authors: Rosanna Qualizza, Laura M Losappio and Fabiana Furci
    Citation: Clinical and Molecular Allergy 2018 16:10
    Content type: Case report Published on:

  15. Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been includ...

    Authors: Boaz Palterer, Gianfranco Vitiello, Alessia Carraresi, Maria Grazia Giudizi, Daniele Cammelli and Paola Parronchi
    Citation: Clinical and Molecular Allergy 2018 16:5
    Content type: Review Published on:

  17. The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescen...

    Authors: Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi and Rosalba Buquicchio
    Citation: Clinical and Molecular Allergy 2017 15:21
    Content type: Review Published on:

  18. Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity react...

    Authors: Malik Ghannam, Shaden Mansour, Aya Nabulsi and Qusay Abdoh
    Citation: Clinical and Molecular Allergy 2017 15:14
    Content type: Case Report Published on:

  19. CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that ch...

    Authors: Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato and Lorenzo Cosmi
    Citation: Clinical and Molecular Allergy 2016 14:16
    Content type: Research Published on:

  20. The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal enviro...

    Authors: Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Antonio Lobasso, Filomena Napolitano, Francescopaolo Granata, Carmine Selleri and Amato de Paulis
    Citation: Clinical and Molecular Allergy 2016 14:15
    Content type: Research Published on:

  21. Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involveme...

    Authors: Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Donatella Sangari, Santa Cirmi, Roneka L. Ravenell, Michele Navarra, Gianfilippo Bagnato and Sebastiano Gangemi
    Citation: Clinical and Molecular Allergy 2016 14:13
    Content type: Case Report Published on:

  22. Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of different effectors mechanisms of the immune system, namely antibodies and T cells. Their occurrence may be associated with...

    Authors: Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Paola Parronchi and Sergio Romagnani
    Citation: Clinical and Molecular Allergy 2016 14:11
    Content type: Review Published on:

  23. Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involv...

    Authors: Letizia Lombardelli, Federica Logiodice, Maryse Aguerre-Girr, Ornela Kullolli, Herman Haller, Ysabel Casart, Alain Berrebi, Fatima-Ezzahra L’Faqihi-Olive, Valérie Duplan, Sergio Romagnani, Enrico Maggi, Daniel Rukavina, Philippe Le Bouteiller and Marie-Pierre Piccinni
    Citation: Clinical and Molecular Allergy 2016 14:1
    Content type: Research Published on:

  24. Clinically amyopathic dermatomyositis (CADM), described almost 50 years ago, is defined on the basis of still not validated criteria and characterized by skin findings almost without muscle weakness. Autoantib...

    Authors: Paola Parronchi, Anna Radice, Boaz Palterer, Francesco Liotta and Cristina Scaletti
    Citation: Clinical and Molecular Allergy 2015 13:22
    Content type: Review Published on:

  25. The aetiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is still unknown. The role of atopy and the concept of united airways in such patients are still a matter of debate. In this pilot stu...

    Authors: Mona-Rita Yacoub, Matteo Trimarchi, George Cremona, Sara Dal Farra, Giuseppe Alvise Ramirez, Valentina Canti, Emanuel Della Torre, Mattia Baldini, Patrizia Pignatti, Mario Bussi, Maria Grazia Sabbadini, Angelo A Manfredi and Giselda Colombo
    Citation: Clinical and Molecular Allergy 2015 13:23
    Content type: Research Published on:

  26. TNF-like ligand 1A (TL1A), a recently recognized member of the TNF superfamily, and its death domain receptor 3 (DR3), firstly identified for their relevant role in T lymphocyte homeostasis, are now well-known...

    Authors: M. Facco, A. Cabrelle, F. Calabrese, A. Teramo, F. Cinetto, S. Carraro, V. Martini, F. Calzetti, N. Tamassia, M. A. Cassatella, G. Semenzato and C. Agostini
    Citation: Clinical and Molecular Allergy 2015 13:16
    Content type: Research Published on:

  27. Crohn’s disease (CD) and Hidradenitis suppurativa (HS) are both chronic inflammatory diseases. The pathogenesis of these diseases is multifactorial, due to the interaction of genetic and environmental factors ...

    Authors: Francesco Giudici, Laura Maggi, Raffaella Santi, Lorenzo Cosmi, Cristina Scaletti, Francesco Annunziato, Gabriella Nesi, Giusi Barra, Gabrio Bassotti, Raffaele De Palma and Francesco Tonelli
    Citation: Clinical and Molecular Allergy 2015 13:12
    Content type: Research Published on:

  28. Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release vario...

    Authors: Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Sergio Romagnani and Philippe Le Bouteiller
    Citation: Clinical and Molecular Allergy 2015 13:9
    Content type: Review Published on:


The official journal of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC)

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Clinical and Molecular Allergy

ISSN: 1476-7961

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