All rhinitics were consecutive subjects meeting the inclusion and exclusion criteria and agreeing to join the study.
No adverse event was reported during the study.
Sensitizations
all subjects were sensitized both to perennial allergens and pollen allergens. Twenty subjects had 2 sensitizations, 34 had 3 sensitizations, and 46 had more than 3 sensitizations. There was no relationship between number of sensitizations and spirometric data.
Spirometry
six patients showed a FEV1 value less than 80% of the predicted. It has to be mentioned that all of them were completely asymptomatic for complaints concerning lower airways. A bronchial reversibility was achieved in all subjects.
In addition, 7 patients showed impaired FVC values and 28 patients showed abnormal FEF 25–75 values.
Methacholine bronchial challenge
it was performed in 94 rhinitics. Sixty-six rhinitics showed a positive methacholine challenge. On the basis of BHR degree, we subdivided the methacholine positive patients in 4 groups: very mild, mild, moderate, and severe. Seventeen patients had a very mild degree of BHR, 16 had a mild degree, 10 had a moderate degree, and 23 a severe degree.
Then, we analyzed subjects subdividing them in two groups: patients with BHR (BHR positive group) and patients without BHR (BHR negative group). Thus, we evaluated the distribution of the patients considering FEV1, FVC, and FEF 25–75 values (Figure 1). FEV1 values were normal in both groups. Five subjects in the BHR positive group and 2 in the BHR negative group had reduced values of FVC only. FEF 25–75 values were reduced in 28 subjects of BHR positive group only (p < 0.001).
We considered the three spirometric parameters related with BHR degree (Figure 2). A significant difference was observed for both FEV1 and FEF 25–75 considering BHR severity in subjects with moderate BHR (p < 0.001 for FEF 25–75 only) and with severe BHR (p < 0.05 for FEV1 and p < 0.001 for FEF 25–75).
Discussion
Allergic rhinitis and asthma should be considered as a single syndrome involving two parts of the respiratory tract, even though it is evident that these two disorders affect each other [16].
Allergic rhinitics frequently present a non-specific BHR even in absence of asthmatic symptoms. In these subjects with normal FEV1 values, BHR may be envisaged as a marker of susceptibility to develop asthma. On the other hand, in mild asthmatics during intercritical periods lung function may be normal concerning FEV1 values [17]. Moreover, asthma is a chronic inflammatory disease of airways and using other parameters it has been demonstrated a persistence of inflammation, also in absence of symptoms, mainly involving smaller airways [18]. In these cases, abnormal FEF 25–75 values may be observed: it has been reported that FEF 25–75 may be reduced in asthmatics with normal FEV1 and FVC values [8]. It has been suggested that FEF 25–75 might be considered a marker of small airways impairment in mild asthmatics with normal FVC values [7].
Very recently, we demonstrated some interesting findings in a group of 100 patients with perennial allergic rhinitis alone [12]. Five patients showed impaired FEV1 values (<80% of predicted), without any perceived lower respiratory symptoms [12]. Moreover, 72 patients showed positive methacholine challenge, and there was a significant relationship between BHR degree and FEV1 and FEF 25–75 values [12]. Thus, we aimed at investigating a large group of polysensitized patients with allergic rhinitis during the pollen season to evaluate spirometry and BHR.
The present findings suggest some considerations concerning the link between upper and lower airways.
Firstly, evaluating a large cohort of polysensitized subjects with allergic rhinitis alone, it is possible to single out some subjects (six) with overt bronchial obstruction, as documented by impaired FEV1 values. These patients may be considered as "poor perceiver" of their lower respiratory symptoms. In fact, all of them had a normal life playing different sports without trouble. In addition, they never felt lower respiratory symptoms nor diagnosis of asthma has been made. It is noteworthy that this finding confirms that demonstrated in perennial rhinitics (5 patients with overt bronchial obstruction).
Secondly, most of our rhinitics (66 subjects) showed BHR. This finding is not surprising if compared with literature analysis and confirm our previous findings in patients with perennial allergic rhinitis. The exposure to allergens is characterized by nasal inflammation as previously described by ourselves [19]. This concept may be consistent with a consequent bronchial inflammation. It is noteworthy that BHR was asymptomatic in all our rhinitics.
Thirdly, considering the evaluation of FEF 25–75 parameter we demonstrated that some rhinitics (28 subjects) shows an initial level of bronchial obstruction during the pollen season. It has to be highlighted that BHR positive patients only showed this impairment. This finding may underline the relevance of considering this parameter as it was impaired only in BHR subjects. Thus, FEF 25–75 could be envisaged as marker of bronchial involvement in pure rhinitics with BHR.
Fourthly, there is a relationship between degree of BHR and FEV1 and FEF 25–75 impairment. These last findings underline the relationship between BHR and airway caliber in patients with airway inflammation. Moreover, these data, taken together, partially confirm previous results observed in patients with perennial allergic rhinitis alone [12]. Polysensitized patients with allergic rhinitis, compared with patients with perennial allergic rhinitis, even more show an association with asthma, the impairment of FEF 25–75, the BHR, and the relationship between BHR grade and spirometric abnormalities. Actually, it is clear that allergic inflammation is chronic in these subjects and it is exacerbated by pollen exposure.