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Table 2 Summary of evidence on the efficacy of cetirizine in the treatment of allergic rhinitis

From: Cetirizine use in childhood: an update of a friendly 30-year drug

ReferencesDiseaseSubjectsMain results
Ciprandi et al. [20]Perennial allergic rhinitis20 childrenDecreasing of nasal IL-4 and IL-8 levels
Uguz et al. [21]Perennial allergic rhinitis13 childrenIncreasing the production of IFN-gamma and IL-10
Allegra et al. [22]Seasonal allergic rhinitis107 children aged 2–6 yearsImprovement in sneezing, rhinorrhea, nasal obstruction, nasal and ocular pruritus than placebo
Masi et al. [23]Seasonal allergic rhinitis124 children aged 6–12 yearsImprovement in sneezing, rhinorrhea, nasal obstruction, nasal and ocular pruritus than placebo
Pearlman et al. [14]Seasonal allergic rhinitis209 children aged 6–11 yearsImprovement in sneezing, nasal discharge, itchy eyes, itchy nose or mouth, conjunctivitis, nasal congestion than placebo
Nayak et al. [25]Seasonal allergic rhinitis683 children aged 6–11 yearsImprovement in TSSC than loratadine and placebo
Lee et al. [26]Perennial allergic rhinitis74 children aged 6–12 yearsImprovement in TSS than levocetirizine and placebo
Chen et al. [27]Perennial allergic rhinitis60 children aged 2–6 yearsImprovement in eosinophil percentage in nasal smears, PRQLQ and TSS. Cetirizine better than montelukast for itching
Ciprandi et al. [28]Rhinitis and/or mild asthma10 childrenImprovement in symptoms and reduction of drug consumption than placebo
Ciprandi et al. [29]Mite allergy20 childrenLower incidence of new sensitisations
Pearlman et al. [30]Seasonal allergic rhinitis209 children aged 6–11 yearsImprovement in TSS than placebo
  1. TSSC total symptom score complex, TSS total symptom score, PRQLQ paediatric rhinoconjunctivitis quality of life questionnaire