Table 2 Summary of evidence on the efficacy of cetirizine in the treatment of allergic rhinitis
From: Cetirizine use in childhood: an update of a friendly 30-year drug
References | Disease | Subjects | Main results |
|---|---|---|---|
Ciprandi et al. [20] | Perennial allergic rhinitis | 20 children | Decreasing of nasal IL-4 and IL-8 levels |
Uguz et al. [21] | Perennial allergic rhinitis | 13 children | Increasing the production of IFN-gamma and IL-10 |
Allegra et al. [22] | Seasonal allergic rhinitis | 107 children aged 2–6 years | Improvement in sneezing, rhinorrhea, nasal obstruction, nasal and ocular pruritus than placebo |
Masi et al. [23] | Seasonal allergic rhinitis | 124 children aged 6–12 years | Improvement in sneezing, rhinorrhea, nasal obstruction, nasal and ocular pruritus than placebo |
Pearlman et al. [14] | Seasonal allergic rhinitis | 209 children aged 6–11 years | Improvement in sneezing, nasal discharge, itchy eyes, itchy nose or mouth, conjunctivitis, nasal congestion than placebo |
Nayak et al. [25] | Seasonal allergic rhinitis | 683 children aged 6–11 years | Improvement in TSSC than loratadine and placebo |
Lee et al. [26] | Perennial allergic rhinitis | 74 children aged 6–12 years | Improvement in TSS than levocetirizine and placebo |
Chen et al. [27] | Perennial allergic rhinitis | 60 children aged 2–6 years | Improvement in eosinophil percentage in nasal smears, PRQLQ and TSS. Cetirizine better than montelukast for itching |
Ciprandi et al. [28] | Rhinitis and/or mild asthma | 10 children | Improvement in symptoms and reduction of drug consumption than placebo |
Ciprandi et al. [29] | Mite allergy | 20 children | Lower incidence of new sensitisations |
Pearlman et al. [30] | Seasonal allergic rhinitis | 209 children aged 6–11 years | Improvement in TSS than placebo |