Table 1 Main demographic, clinical and functional data of the group of severe asthmatics

Age, years (nean ± sd)

59.1 ± 11.1

Gender, M/F (%)

34.7/65.3

Smoke, Y/Ex/N (%)

5.5/33.3/61.2

Atopy (%)

47 (65.2)

Duration of disease, yrs (median and range)

20.6 (2–57)

Age of asthma onset, yrs (median and range)

40 (2–68)

Early onset asthma, n (%)

10 (13.8)

Post-bronc FEV1, % of pred (mean ± SD)

86.6 ± 17.8

FeNO, ppb (median and range)

22.4 (3.5–86.5)

Sputum eosinophils, % (median and range)

18 (0–95.6)

Sputum neutrophils, % (median and range)

29 (0–96.9)

Blood eosinophils, cells/µl (median and range)

285 (0–2490)

Blood Eosinophils, % (median and range)

4.5 (0–30)

Total IgE, IU/mL (median and range)

275.9 (8.1–3830)

ACT (median and range)

19 (7–25)

ACQ (median and range)

1.65 (0–3.7)

AQLQ (median and range)

4.7 (2.7–6.9)

PEF variability (median and range)

18.6 (3.7–47)

GINA, not controlled, n (%)

37 (51.4)

Exacerbations, no./last year (median and range)

1 (0–15)