Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature

Table 4 Treatment, culprit and tolerated drugs after and during SCARs

Patient	SCARs	Culprit drug	Latency (weeks)	Treatment	Tolerated anticonvulsants	Other tolerated drugs
P1	DRESS	Phenytoin	3	Methylprednisolone for 3 months	Clonazepam	Ibuprofen, clarithromycin
P2	DRESS	Phenytoin	3	Prednisone for 1 year	Levetiracetam	Metamizole, tramadol, amoxicillin, clarithromycin, ketoprofen, metoclopramide, rituximab, lercanidipine
P3	SJS	Lamotrigine	4	Hydrocortisone bolus, prednisone for 1 month and immunoglobulin intravenously	Delorazepam and lormetazepam	Echinocandin
P4	SJS	Phenytoin	4	Hydrocortisone bolus, prednisone for 1 month and immunoglobulin intravenously	Diazepam	Teicoplanin, haloperidol
P5	TEN	Valproic acid	2	Prednisone for 1 month and immunoglobulin intravenously	Diazepam and levetiracetam	Meropenem
P6	TEN	Lamotrigine	2	Prednisone for 1 month and immunoglobulin intravenously	Diazepam and levetiracetam	Teicoplanin

SCARs: severe cutaneous adverse reactions, SJS: Stevens–Johnson syndrome, DRESS: drug reaction with eosinophilia and systemic symptoms, TEN: toxic epidermal necrolysis

ISSN: 1476-7961