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Table 4 Treatment, culprit and tolerated drugs after and during SCARs

From: Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature

Patient SCARs Culprit drug Latency (weeks) Treatment Tolerated anticonvulsants Other tolerated drugs
P1 DRESS Phenytoin 3 Methylprednisolone for 3 months Clonazepam Ibuprofen, clarithromycin
P2 DRESS Phenytoin 3 Prednisone for 1 year Levetiracetam Metamizole, tramadol, amoxicillin, clarithromycin, ketoprofen, metoclopramide, rituximab, lercanidipine
P3 SJS Lamotrigine 4 Hydrocortisone bolus, prednisone for 1 month and immunoglobulin intravenously Delorazepam and lormetazepam Echinocandin
P4 SJS Phenytoin 4 Hydrocortisone bolus, prednisone for 1 month and immunoglobulin intravenously Diazepam Teicoplanin, haloperidol
P5 TEN Valproic acid 2 Prednisone for 1 month and immunoglobulin intravenously Diazepam and levetiracetam Meropenem
P6 TEN Lamotrigine 2 Prednisone for 1 month and immunoglobulin intravenously Diazepam and levetiracetam Teicoplanin
  1. SCARs: severe cutaneous adverse reactions, SJS: Stevens–Johnson syndrome, DRESS: drug reaction with eosinophilia and systemic symptoms, TEN: toxic epidermal necrolysis