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Table 1 Associations between HLA-A and -B haplotypes and severe anticonvulsant reactions

From: Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature

Disease Culprit drug HLA haplotype Population Authors (ref. number)
SJS ⁄TEN Carbamazepine HLA-B*15:02 Asians [1113]
SJS/TEN and DRESS Carbamazepine HLA-A*31:01 Europeans [14, 15]
SJS/TEN and DRESS Phenytoin HLA-B*15:13 and -B*15:02 Malaysians [16]
  1. SJS: Stevens Johnson syndrome, TEN: toxic epidermal necrolysis, DRESS: drug reaction with eosinophilia and systemic symptoms