Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature

Table 1 Associations between HLA-A and -B haplotypes and severe anticonvulsant reactions

Disease	Culprit drug	HLA haplotype	Population	Authors (ref. number)
SJS ⁄TEN	Carbamazepine	HLA-B*15:02	Asians	[11–13]
SJS/TEN and DRESS	Carbamazepine	HLA-A*31:01	Europeans	[14, 15]
SJS/TEN and DRESS	Phenytoin	HLA-B15:13 and -B15:02	Malaysians	[16]

SJS: Stevens Johnson syndrome, TEN: toxic epidermal necrolysis, DRESS: drug reaction with eosinophilia and systemic symptoms

ISSN: 1476-7961