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Table 1 Comparison between the laboratory findings in the two MDA5+ patients with dermatomyositis

From: MDA5-positive dermatomyositis: an uncommon entity in Europe with variable clinical presentations

  Patient #1 Patient #2 Reference values
Total blood counts
 WBC 1.67 5.17 4–10 × 109/L
 Neutrophils 1.08 1.66 1.5–7.5 × 109/L
 Lymphocytes 0.27 2.67 1–5 × 109/L
 Hb 9.8 12.8 13–16 g/dL
 PLTs 130 217 140–440 × 109/L
Liver enzymes
 AST 244 28 15–37 U/L
 ALT 263 48 12–65 U/L
Cholestasis indexes
 ɣ-GT 399 117 5–85 U/L
 AP 120 92 50–136 U/L
Total bilirubin 0.7 0.5 0.2–1 mg/dL
Muscle enzymes
 LDH 483 255 84–246 U/L
 CPK 662 28 35–232 U/L
 Aldolase 11.2 7.4 <7.3 U/mL
Indexes of inflammation
 ESR 50 41 2–10 mm/h
 CRP <9 <9 <9 mg/L
 Ferritin 4218 292 26–388 ng/mL
Autoantibodies
 ANA 1/640 Neg <1/80
 Anti-MDA5 +++ (72) +++ (58) Neg
 Anti-Ro52 +++ (84) Neg Neg
  1. All the values reported were measured at admission in the absence of therapy. Anti-nuclear antibodies (ANA) were determined by means of indirect immunofluorescence on Hep2 cells (Euroimmun). Anti-MDA5 and anti-Ro52 kDa were determined by a validated commercial Immunoblot method (Euroimmun) (in brackets, levels of autoantibodies as automatically calculated by the EUROLineScan software)