Fig. 3
From: TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis
Immunohistochemistry for TL1A and DR3 expression in representative patients with active (A, B) and refractory sarcoidosis and pulmonary fibrosis (C, D). A, B. TL1A and DR3 are expressed at high intensity by macrophagic, both epitheliod and multinucleated, cells and lymphocytes infiltrating the lung biopsy of the patient with active sarcoidosis. The black arrows indicate positive metaplastic epithelial cells. C, D. In the lung specimen obtained from a patient with refractory sarcoidosis and pulmonary fibrosis, pulmonary cells were mainly non reactive for TL1A and DR3; a weak immunostaining was only seen in some epitheliod cells (arrows). Note marked fibrosis around the granulomatous nodule. Original magnification 400x