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Table 4 A summary of treatment options for Henoch-Schonlein Purpura

From: The clinical implications of adult-onset henoch-schonelin purpura

Medication Indication
Acetaminophen, NSAID Mild eruption, arthritis
Colchicine Severe or recurrent skin disease
Oral glucocorticoids Severe eruption, cutaneous edema, severe colicky abdominal pain, scrotal and testicular involvement
Parenteral glucocorticoids Same as oral; unable to tolerate oral medications
High dose parenteral pulse glucocorticoid Nephrotic range proteinuria
High dose IV pulse glucocorticoids combined with other forms of immunosuppression (such as cyclophosphamide) Rapidly progressive glomerulonephritis Hemorrhagic involvement of lungs or brain
Plasmapheresis and/or IGIV Refractory to combination therapy Massive hemorrhage in gastrointestinal or other organs
  1. IV = intravenous; IGIV = intravenous immunoglobulin