Table 9 Approach to Diagnosis of CGD
From: Chronic granulomatous disease: a review of the infectious and inflammatory complications
Clinical information |
   1. Severe, recurrent pulmonary and hepatic infections including abscess formation |
   2. Specific etiologic pathogens such as B. cepacia, Nocardia, Aspergillus etc |
   3. Granulomatous lesions of the GI tract or the GU system |
Laboratory abnormalities |
   1. Anemia |
   2. Polyclonal hyperglobulinemia |
   3. Elevated acute phase reactants such as ESR or CRP |
   4. Normal studies of T and B lymphocyte immunity |
Diagnostic test |
   1. NBT test (no longer used) |
   2. DHR |
Molecular tests |
   1. Immunoblotting or flow cytometry |
   2. Molecular techniques including gene sequencing and mutational analyses for subtype |