Table 1 The Physiological Properties of Immunoglobulin E
From: Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective
General Characteristics | Molecular weight: 190,000 Da (170 kDa protein; 20 kDa Carbohydrate) Type: Monomer Subclasses: None |
|---|---|
Biology | Does not fix complement Does not cross the placental barrier Half-life: 2 days Isoforms: Secreted and membrane bound IgE Structure: Two light chains (κ or λ) and 2 heavy chains (ε) |
Function | Binds to High affinity IgE receptor (FcεRI) and degranulates mast cells and basophils Immediate Hypersensitivity IgE-mediated antigen presentation via FcεRI |