Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma

Table 4 Age 5 Cockroach Antigen-Induced PBMC Proliferation and IgE at Age 5 years

	Outcomes
	Anti-cockroach IgE ≥ 0.35 IU/ml		Total IgE (IU/ml)
Predictors	Crude OR (95% CI) [n = 113]	Adjusted OR (95% CI) [n = 78]	Crude β [n = 124]	Adjusted β [n = 85]
Positive cockroach-induced PBMC proliferation	1.75 (0.69, 4.42)	3.39 (1.05, 10.92)	0.63 (p = 0.02)	1.05 (p = 0.00)
Female sex	NA	0.64 (0.22, 1.87)	NA	-0.80 (p = 0.02)
African American ethnicity (Reference = Dominican)	NA	01.12 (0.36, 3.46)	NA	0.30 (p = 0.37)
Age 5 ETS exposed	NA	0.83 (0.27, 2.53)	NA	-0.22 (p = 0.51)
Maternal history of asthma	NA	1.20 (0.38, 3.77)	NA	0.31 (p = 0.39)
Prenatal cockroach allergen in bed (μg/g dust)	NA	0.71 (0.46, 1.12)	NA	-0.10 (p = 0.36)

Results were based on univariate and multivariate, logistic and linear regression models. The endpoint anti-cockroach IgE is shown as odds ratio, and total IgE as regression coefficients with two-tailed p-values. Interaction terms each examined in a separate model [data not shown] demonstrated significant interactions between age 5 cockroach-induced PBMC proliferation with ethnicity (p = 0.04) and sex (p = 0.01) on age 5 anti-cockroach IgE. In stratified adjusted models, there were significant positive associations between age 5 cockroach-induced PBMC proliferation and age 5 anti-cockroach IgE amongst African Americans (β = 1.86, p = 0.00) and girls (β = 1.05, p = 0.00). Maternal asthma was defined as positive at either prenatal or 3-months postnatal time points. Cockroach prenatal allergen levels (μg/g of dust) are expressed as natural log-transformed values. OR, odds ratio. ETS, environmental tobacco smoke. NA, not applicable.

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