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Table 4 Age 5 Cockroach Antigen-Induced PBMC Proliferation and IgE at Age 5 years

From: Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma

  Outcomes
  Anti-cockroach IgE0.35 IU/ml Total IgE (IU/ml)
Predictors Crude OR
(95% CI)
[n = 113]
Adjusted OR
(95% CI)
[n = 78]
Crude β
[n = 124]
Adjusted β
[n = 85]
Positive cockroach-induced PBMC proliferation 1.75 (0.69, 4.42) 3.39 (1.05, 10.92) 0.63 (p = 0.02) 1.05 (p = 0.00)
Female sex NA 0.64 (0.22, 1.87) NA -0.80 (p = 0.02)
African American ethnicity
(Reference = Dominican)
NA 01.12 (0.36, 3.46) NA 0.30 (p = 0.37)
Age 5 ETS exposed NA 0.83 (0.27, 2.53) NA -0.22 (p = 0.51)
Maternal history of asthma NA 1.20 (0.38, 3.77) NA 0.31 (p = 0.39)
Prenatal cockroach allergen in bed (μg/g dust) NA 0.71 (0.46, 1.12) NA -0.10 (p = 0.36)
  1. Results were based on univariate and multivariate, logistic and linear regression models. The endpoint anti-cockroach IgE is shown as odds ratio, and total IgE as regression coefficients with two-tailed p-values. Interaction terms each examined in a separate model [data not shown] demonstrated significant interactions between age 5 cockroach-induced PBMC proliferation with ethnicity (p = 0.04) and sex (p = 0.01) on age 5 anti-cockroach IgE. In stratified adjusted models, there were significant positive associations between age 5 cockroach-induced PBMC proliferation and age 5 anti-cockroach IgE amongst African Americans (β = 1.86, p = 0.00) and girls (β = 1.05, p = 0.00). Maternal asthma was defined as positive at either prenatal or 3-months postnatal time points. Cockroach prenatal allergen levels (μg/g of dust) are expressed as natural log-transformed values. OR, odds ratio. ETS, environmental tobacco smoke. NA, not applicable.