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Table 3 Adjusted1) associations of 10 cytokine polymorphisms with elevated serum levels of total IgE in the ECRHS-Basel Study.

From: Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)

  Elevated total IgE cases2)
Genotype   cases/controls 3) Odds Ratio 95% Conficence Interval P-value
IL4 (-589C>T) CC 69/227 1 -- --
  CT 25/81 1 0.57 – 1.65 0.91
  TT 7/6 3.89 1.24 – 12.15 0.02
IL4R Q576R (A>G) AA 67/194 1 -- --
  AG 30/105 0.91 0.55 – 1.50 0.71
  GG 4/9 1.31 0.38 – 4.51 0.67
IL6(-174G>C) GG 34/98 1 -- --
  GC 49/151 0.91 0.54 – 1.52 0.71
  CC 18/62 0.80 0.41 – 1.56 0.52
IL10 (-1082G>A) GG 35/112 1 -- --
  GA 54/137 1.22 0.74 – 2.01 0.44
  AA 12/64 0.55 0.27 – 1.16 0.12
IL10 (-819C>T) CC 44/180 1 -- --
  CT 48/112 1.81 1.12 – 2.92 0.02
  TT 9/20 1.96 0.82 – 4.67 0.13
IL12p40(1188A>C) AA 61/183 1 -- --
  AC 39/112 1.03 0.64 – 1.66 0.89
  CC 1/18 0.16 0.02 – 1.20 0.08
IL13 R130Q (A>G) GG 68/206 1 -- --
  GA 28/96 0.82 0.49 – 1.37 0.46
  AA 5/9 2.14 0.67 – 6.78 0.19
IL18(-137G>C) GG 43/163 1 -- --
  GC 42/127 1.22 0.75 – 2.00 0.42
  CC 16/24 2.51 1.21 – 5.20 0.01
TNF(-308G>A) GG 66/220 1 -- --
  GA 33/85 1.41 0.86 – 2.32 0.17
  AA 2/7 1.18 0.23 – 5.98 0.84
CD14 (-159C>T) CC 24/88 1 -- --
  CT 55/140 1.44 0.83 – 2.52 0.19
  TT 21/79 0.97 0.50 – 1.90 0.94
  1. 1) Adjusted for age and gender.
  2. 2) Elevated total IgE cases had serum IgE level >100 kU/L, measured by CAP system (Pharmacia Diagnostics). Controls had IgE = 100 kU/L.
  3. 3) Controls had IgE = 100 kU/L