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Table 2 Adjusted1) associations of 10 cytokine polymorphisms with self-reported hay fever in the ECRHS-Basel Study.

From: Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)

Genotype   cases/controls2) Odds Ratio 95% Confidence Interval P-value
IL4 (-589C>T) CC 140/89 1 -- --
rs2243250 CT 47/31 0.99 0.58 – 1.68 0.98
  TT 5/5 0.56 0.16 – 2.03 0.38
IL4R Q576R (A>G) AA 128/71 1 -- --
rs1801275 AG 58/45 0.68 0.42 – 1.13 0.12
  GG 5/5 0.59 0.16 – 2.11 0.39
IL6(-174G>C) GG 65/33 1 -- --
rs1800795 GC 97/66 0.77 0.45 – 1.30 0.32
  CC 28/25 0.58 0.29 – 1.15 0.12
IL10 (-1082G>A) GG 60/48 1 -- --
rs1800896 GA 96/50 1.58 0.94 – 2.6 0.08
  AA 36/26 1.15 0.61 – 2.18 0.66
IL10 (-819C>T) CC 102/71 1 -- --
rs1800871 CT 77/42 1.26 0.77 – 2.04 0.35
  TT 11/12 0.64 0.27 – 1.54 0.32
IL12p40(1188A>C) AA 114/74 1 -- --
rs3212227 AC 69/44 0.99 0.61 – 1.59 0.95
  CC 9/6 1.05 0.36 – 3.09 0.93
IL13 R130Q (A>G) GG 127/82 1 -- --
rs20541 GA 57/38 0.96 0.58 – 1.58 0.87
  AA 6/4 0.99 0.27 – 3.68 0.99
IL18(-137G>C) GG 101/55 1 -- --
rs187238 GC 73/54 0.75 0.46 – 1.22 0.25
  CC 18/15 0.65 0.30 – 1.39 0.27
TNF(-308G>A) GG 135/84 1 -- --
rs1800629 GA 53/35 0.94 0.57 – 1.57 0.83
  AA 4/4 0.58 0.14 – 2.40 0.45
CD14 (-159C>T) CC 49/41 1 -- --
rs2569190 CT 89/55 1.36 0.79 – 2.32 0.26
  TT 51/26 1.64 0.88 – 3.09 0.12
  1. 1) Adjusted for age and gender.
  2. 2) Hay fever cases answered yes to 'Have you ever had a problem with sneezing or a runny nose or a blocked nose when you did not have a cold?', irrespective of self-reported asthma or eczema. Non-atopic controls were free of self-reported hay fever, self-reported eczema and physician-diagnosed asthma.