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Table 6 Nonskeletal Effects of Pharmacologic Therapy.

From: Management of osteoporosis

Medication

Pros

Con

Estrogen

Relieves Menopausal symptoms, Cholesterol, LDL, HDL

Uterine Bleeding, Thromboembolic Disorders, Stroke, Coronary Artery Disease, Estrogen Sensitive Tumors, Triglyceride, Breast Tenderness, Fluid Retention

Alendronate/Risedronate

Weekly Dosing

Complicated Administration, GI Effects

Raloxifene

Cholesterol, LDL, Reduced Breast Cancer Risk?, Cardiovascular?

Hot Flashes, Thromboembolic Disorders, Leg Cramps

Nasal Calcitonin

Ease of Administration, Analgesic Effect

Nasal Irritation

Teriparatide

Analgesic Effect?

Osteosarcoma in Rats, Injectable, Refrigeration, Hypercalcemia

  1. The selection of the best pharmacologic agent for an individual patient requires a thorough understanding of patient factors and all drug effects, both skeletal and nonskeletal.
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Clinical and Molecular Allergy

ISSN: 1476-7961

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