Figure 2

Pathology of eosinophilic gastritis. In the presence of an inciting event, inflammatory cells like T-cells and mast cells are activated to produce a host of eosinophilic cytokines that regulate eosinophil biology, activation, recruitment, and survival. Once in the gastric mucosa, eosinophils can orchestrate tissue damage by releasing toxic proteins like eosinophil cationic protein, major basic protein, eosinophil peroxidase, and eosinophil derived neurotoxin. With mucosal injury, vomiting, diarrhea, cachexia, and peripheral edema ensue.