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Table 3 Systemic medications which have been used for treatment of RAU

From: Remission of severe aphthous stomatitis of celiac disease with etanercept

Medication Number of patients Results/outcome Reference
Pentoxifylline 400 mg TID 26 people ↓ ulcer size [14]
14 patients ↓ ulcers number
12 control
Doxycyline 20 mg BID 50 patients ↑ remission [15]
↓ pain
Zinc sulfate 150 mg BID 45 patients ↓ ulcer size [16]
↓ symptoms
Cholchicine (1–2) mg BID 169 patients ↓ ulcer number [17]
↓ disease duration
Clofazimine 100 mg QD For 1 month 23 patients ↓ ulcers number [18]
↓ disease duration
In 44%
Prednisone up to 25 mg 60 patients ↓ ulcers number [19]
Faster healing
Montelukast 10 mg QD 60 patients ↓ ulcers number [20]
Faster healing
Thalidomide 50 mg QD 200 mg QD for HIV patients 20 HIV patients Induce remission [21]
In HIV patients
Chlorambucil 0.1 mg/kg Single case report Remission [22]
Infliximab 5 mg/kg QD Single case report Remission [23]
Etanercept 25 mg BiWeekly 40 patients ↓ ulcers number [24]
Levamisole 9 patients ↓ ulcers number [25]