The events in the understanding of cetuximab and Alpha-gal-mediated hypersensitivity. With the use of cetuximab in treatment of head and neck cancer and colorectal carcinoma, multiple infusion reactions were reported. Chung el al. in 2008 were able to identify IgE to alpha-gal directed to the Fab portion of cetuximab and was related to the allergic reactions. IgE to alpha-gal was later linked to allergic reactions to red meat in America and Europe. Information from references: [18, 51, 52, 59–74].