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  1. Research

    Comparing the ability of molecular diagnosis and CAP-inhibition in identifying the really causative venom in patients with positive tests to Vespula and Polistes species

    Cross-reactivity among Hymenoptera venoms is an important issue when prescribing venom immunotherapy (VIT). Using all venoms eliciting a positive response results in treatment excess and unjustified cost incre...

    Eleonora Savi, Silvia Peveri, Elena Makri, Valerio Pravettoni and Cristoforo Incorvaia

    Clinical and Molecular Allergy 2016 14:3

    Published on: 8 February 2016

  2. Research

    Skin microbiota of first cousins affected by psoriasis and atopic dermatitis

    Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria ...

    Lorenzo Drago, Roberta De Grandi, Gianfranco Altomare, Paolo Pigatto, Oliviero Rossi and Marco Toscano

    Clinical and Molecular Allergy 2016 14:2

    Published on: 25 January 2016

  3. Research

    Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4

    Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involv...

    Letizia Lombardelli, Federica Logiodice, Maryse Aguerre-Girr, Ornela Kullolli, Herman Haller, Ysabel Casart, Alain Berrebi, Fatima-Ezzahra L’Faqihi-Olive, Valérie Duplan, Sergio Romagnani, Enrico Maggi, Daniel Rukavina, Philippe Le Bouteiller and Marie-Pierre Piccinni

    Clinical and Molecular Allergy 2016 14:1

    Published on: 21 January 2016

  4. Research

    Determinants of venom-specific IgE antibody concentration during long-term wasp venom immunotherapy

    Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE ch...

    Valerio Pravettoni, Marta Piantanida, Laura Primavesi, Stella Forti and Elide A. Pastorello

    Clinical and Molecular Allergy 2015 13:29

    Published on: 15 December 2015

  5. Research

    Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients

    In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlat...

    Carina Gabriela Uasuf, Danilo Villalta, Maria Elisabetta Conte, Caterina Di Sano, Maria Barrale, Vincenzo Cantisano, Elisabetta Pace, Mark Gjomarkaj, Sebastiano Gangemi and Ignazio Brusca

    Clinical and Molecular Allergy 2015 13:30

    Published on: 2 December 2015

  6. Research

    Choosing wisely in Allergology: a Slow Medicine approach to the discipline promoted by the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC)

    One of the main problem health care systems are facis is the mis-use and over-use of medical resources (including useless exams, surgical interventions, medical treatments, screening procedures…) which may lea...

    Enrico Heffler, Massimo Landi, Silvana Quadrino, Cristoforo Incorvaia, Stefano Pizzimenti, Sandra Vernero, Nunzio Crimi, Giovanni Rolla and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2015 13:28

    Published on: 20 November 2015

  7. Research

    Asthma under/misdiagnosis in primary care setting: an observational community-based study in Italy

    Published data suggest that asthma is significantly under/misdiagnosed. The present community-based study performed in Italy aims at investigating the level of asthma under/misdiagnosis among patients referrin...

    Maria Sandra Magnoni, Marco Caminati, Gianenrico Senna, Fabio Arpinelli, Andrea Rizzi, Anna Rita Dama, Michele Schiappoli, Germano Bettoncelli and Gaetano Caramori

    Clinical and Molecular Allergy 2015 13:26

    Published on: 16 November 2015

  8. Research

    Risk of anaphylaxis in patients with large local reactions to hymenoptera stings: a retrospective and prospective study

    In the few studies available, the risk of developing systemic reactions (SR) to hymenoptera stings in patients with previous large local reactions (LLRs) to stings ranges from 0 to 7 %. We evaluated both retro...

    Stefano Pucci, Simona D’Alò, Tiziana De Pasquale, Ilenia Illuminati, Elena Makri and Cristoforo Incorvaia

    Clinical and Molecular Allergy 2015 13:21

    Published on: 9 November 2015

  9. Commentary

    AIT (allergen immunotherapy): a model for the “precision medicine”

    The interpretation of medical approaches, especially therapy, evolved rapidly in the last century. Starting from the simple description of symptoms, we moved to the pathophysiological descriptions, to the evid...

    Giovanni Passalacqua and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2015 13:24

    Published on: 8 October 2015

  10. Review

    Guidelines for the use and interpretation of diagnostic methods in adult food allergy

    Food allergy has an increasing prevalence in the general population and in Italy concerns 8 % of people with allergies. The spectrum of its clinical manifestations ranges from mild symptoms up to potentially f...

    Donatella Macchia, Giovanni Melioli, Valerio Pravettoni, Eleonora Nucera, Marta Piantanida, Marco Caminati, Corrado Campochiaro, Mona-Rita Yacoub, Domenico Schiavino, Roberto Paganelli and Mario Di Gioacchino

    Clinical and Molecular Allergy 2015 13:27

    Published on: 5 October 2015

    The Erratum to this article has been published in Clinical and Molecular Allergy 2015 13:31

  11. Review

    Biomarkers and severe asthma: a critical appraisal

    Severe asthma (SA) is a clinically and etiologically heterogeneous respiratory disease which affects among 5–10 % of asthmatic patients. Despite high-dose therapy, a large patients percentage is not fully cont...

    Alessandra Chiappori, Laura De Ferrari, Chiara Folli, Pierluigi Mauri, Anna Maria Riccio and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2015 13:20

    Published on: 1 October 2015

  12. Research

    Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps?

    The aetiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is still unknown. The role of atopy and the concept of united airways in such patients are still a matter of debate. In this pilot stu...

    Mona-Rita Yacoub, Matteo Trimarchi, George Cremona, Sara Dal Farra, Giuseppe Alvise Ramirez, Valentina Canti, Emanuel Della Torre, Mattia Baldini, Patrizia Pignatti, Mario Bussi, Maria Grazia Sabbadini, Angelo A Manfredi and Giselda Colombo

    Clinical and Molecular Allergy 2015 13:23

    Published on: 11 September 2015

  13. Case Report

    Rituximab in refractory sarcoidosis: a single centre experience

    Sarcoidosis is a granulomatous disease whose outcome varies from spontaneous remission to chronic refractory disease. Provided that steroids represent the gold standard as a first line treatment, many immune s...

    Francesco Cinetto, Nicolò Compagno, Riccardo Scarpa, Giacomo Malipiero and Carlo Agostini

    Clinical and Molecular Allergy 2015 13:19

    Published on: 1 September 2015

  14. Review

    Escaping the trap of allergic rhinitis

    Rhinitis is often the first symptom of allergy but is frequently ignored and classified as a nuisance condition. Ironically it has the greatest socioeconomic burden worldwide caused by its impact on work and o...

    Oliviero Rossi, Ilaria Massaro, Marco Caminati, Cristina Quecchia, Filippo Fassio, Enrico Heffler and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2015 13:17

    Published on: 4 August 2015

  15. Research

    TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis

    TNF-like ligand 1A (TL1A), a recently recognized member of the TNF superfamily, and its death domain receptor 3 (DR3), firstly identified for their relevant role in T lymphocyte homeostasis, are now well-known...

    M. Facco, A. Cabrelle, F. Calabrese, A. Teramo, F. Cinetto, S. Carraro, V. Martini, F. Calzetti, N. Tamassia, M. A. Cassatella, G. Semenzato and C. Agostini

    Clinical and Molecular Allergy 2015 13:16

    Published on: 3 August 2015

  16. Research

    The perception of allergen-specific immunotherapy among pediatricians in the primary care setting

    Allergic respiratory diseases are constantly increasing in prevalence. Allergen Immunotherapy (AIT) represent a valuable therapeutic tool as symptomatic and preventative approach, expecially in children. In It...

    Massimo Landi, Paolo Meglio, Ermanno Praitano, Carlo Lombardi, Giovanni Passalacqua and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2015 13:15

    Published on: 24 July 2015

  17. Research

    Perianal Crohn’s disease and hidradenitis suppurativa: a possible common immunological scenario

    Crohn’s disease (CD) and Hidradenitis suppurativa (HS) are both chronic inflammatory diseases. The pathogenesis of these diseases is multifactorial, due to the interaction of genetic and environmental factors ...

    Francesco Giudici, Laura Maggi, Raffaella Santi, Lorenzo Cosmi, Cristina Scaletti, Francesco Annunziato, Gabriella Nesi, Giusi Barra, Gabrio Bassotti, Raffaele De Palma and Francesco Tonelli

    Clinical and Molecular Allergy 2015 13:12

    Published on: 22 July 2015

  18. Review

    Engineered metal based nanoparticles and innate immunity

    Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used in a large number of applications including medical (for diagnostic and therapeutic purposes). Once inside the ...

    Claudia Petrarca, Emanuela Clemente, Valentina Amato, Paola Pedata, Enrico Sabbioni, Giovanni Bernardini, Ivo Iavicoli, Sara Cortese, Qiao Niu, Takemi Otsuki, Roberto Paganelli and Mario Di Gioacchino

    Clinical and Molecular Allergy 2015 13:13

    Published on: 15 July 2015

  19. Research

    Prevalence of perennial severe allergic asthma in Italy and effectiveness of omalizumab in its management: PROXIMA – an observational, 2 phase, patient reported outcomes study

    We designed the PROXIMA study (Patient-Reported Outcomes and Xolair® In the Management of Asthma) to determine the proportion of patients with severe asthma sensitive to perennial allergens, and to evaluate asthm...

    Giorgio Walter Canonica, Marta Bartezaghi, Raffaele Marino and Laura Rigoni

    Clinical and Molecular Allergy 2015 13:10

    Published on: 7 July 2015

  20. Research

    Identification of risk factors of severe hypersensitivity reactions in general anaesthesia

    Hypersensitivity reactions to anaesthetic agents are rare but often severe, with a mortality ranging from 4 to 9% in IgE-mediated events. Identification of the risk factors may contribute to limit the incidenc...

    Corrado Mirone, Donatella Preziosi, Ambra Mascheri, Gianluigi Micarelli, Laura Farioli, Luca G Balossi, Joseph Scibilia, Jan Schroeder, Laura M Losappio, Maria G Aversano, Chrysi Stafylaraki, Michele Nichelatti and Elide A Pastorello

    Clinical and Molecular Allergy 2015 13:11

    Published on: 22 June 2015

  21. Review

    Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly

    The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a com...

    Nicola Scichilone, Maria T Ventura, Matteo Bonini, Fulvio Braido, Caterina Bucca, Marco Caminati, Stefano Del Giacco, Enrico Heffler, Carlo Lombardi, Andrea Matucci, Manlio Milanese, Roberto Paganelli, Giovanni Passalacqua, Vincenzo Patella, Erminia Ridolo, Giovanni Rolla…

    Clinical and Molecular Allergy 2015 13:7

    Published on: 22 June 2015

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