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  1. Case Report

    Avoiding misdiagnosis in patients with dyspnea and wheezing: a case report illustrating the clinical implications of fixation error

    Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may ...

    Fabiano Di Marco, Giuseppe Francesco Sferrazza Papa, Dejan Radovanovic and Pierachille Santus

    Clinical and Molecular Allergy 2017 15:3

    Published on: 8 February 2017

  2. Review

    Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms

    Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is pa...

    Maria Teresa Ventura, Nicola Scichilone, Roberto Paganelli, Paola Lucia Minciullo, Vincenzo Patella, Matteo Bonini, Giovanni Passalacqua, Carlo Lombardi, Livio Simioni, Erminia Ridolo, Stefano R. Del Giacco, Sebastiano Gangemi and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2017 15:2

    Published on: 3 February 2017

  3. Research

    Clinical management, expectations, and satisfaction of patients with moderate to severe allergic rhinoconjunctivitis treated with SQ-standardized grass-allergen tablet under routine clinical practice conditions in Spain

    Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX® is the most documented product in terms of safety and efficacy. T...

    Tomás Chivato, Pedro Álvarez-Calderón, Carmen Panizo, Ricardo Abengozar, César Alías, Ali Al-Baech, José Arias-Irigoyen, M. José Caballero, Lluis Conill, Silvia de Miguel, Rafael Laguna, Joan Martínez-Benazet, Francisco Matoses, Jose Camilo Martínez-Alonso, Lourdes Mendizábal, Celsa Pérez-Carral…

    Clinical and Molecular Allergy 2017 15:1

    Published on: 6 January 2017

  4. Review

    Different clinical allergological features of Taenia solium infestation

    The tapeworm Taenia (T.) solium can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tis...

    Paola Lucia Minciullo, Antonio Cascio, Stefania Isola and Sebastiano Gangemi

    Clinical and Molecular Allergy 2016 14:18

    Published on: 7 December 2016

  5. Review

    Eosinophilic disorders of the gastro-intestinal tract: an update

    Eosinophilic diseases of the gastrointestinal tract, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), are rare chronic pathologies of the digestive system, with an immuno-mediat...

    Erminia Ridolo, Valerie Melli, Gianluigi De’ Angelis and Irene Martignago

    Clinical and Molecular Allergy 2016 14:17

    Published on: 1 December 2016

  6. Research

    Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients

    CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that ch...

    Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato and Lorenzo Cosmi

    Clinical and Molecular Allergy 2016 14:16

    Published on: 8 November 2016

  7. Research

    HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4

    The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal enviro...

    Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Antonio Lobasso, Filomena Napolitano, Francescopaolo Granata, Carmine Selleri and Amato de Paulis

    Clinical and Molecular Allergy 2016 14:15

    Published on: 1 November 2016

  8. Case Report

    Mastocytosis and systemic sclerosis: a clinical association

    Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involveme...

    Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Donatella Sangari, Santa Cirmi, Roneka L. Ravenell, Michele Navarra, Gianfilippo Bagnato and Sebastiano Gangemi

    Clinical and Molecular Allergy 2016 14:13

    Published on: 11 October 2016

  9. Review

    Burden of allergic respiratory disease: a systematic review

    This meta-analysis compared the health-related quality of life (HRQL) of patients with allergic rhinitis (AR) and/or allergic asthma (AA) caused by perennial house dust mite (HDM) versus AR and/or AA caused by...

    A. Linneberg, K. Dam Petersen, J. Hahn-Pedersen, E. Hammerby, N. Serup-Hansen and N. Boxall

    Clinical and Molecular Allergy 2016 14:12

    Published on: 28 September 2016

  10. Review

    How pregnancy can affect autoimmune diseases progression?

    Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of different effectors mechanisms of the immune system, namely antibodies and T cells. Their occurrence may be associated with...

    Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Paola Parronchi and Sergio Romagnani

    Clinical and Molecular Allergy 2016 14:11

    Published on: 15 September 2016

  11. Review

    Unmet diagnostic needs in contact oral mucosal allergies

    The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the...

    Paola Lucia Minciullo, Giovanni Paolino, Maddalena Vacca, Sebastiano Gangemi and Eustachio Nettis

    Clinical and Molecular Allergy 2016 14:10

    Published on: 1 September 2016

  12. Review

    Drug induced exfoliative dermatitis: state of the art

    Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multi...

    Mona-Rita Yacoub, Alvise Berti, Corrado Campochiaro, Enrico Tombetti, Giuseppe Alvise Ramirez, Andrea Nico, Elisabetta Di Leo, Paola Fantini, Maria Grazia Sabbadini, Eustachio Nettis and Giselda Colombo

    Clinical and Molecular Allergy 2016 14:9

    Published on: 22 August 2016

  13. Research

    Pilot study: assessing the clinical diagnosis of allergy in atopic children using a microarray assay in addition to skin prick testing and serum specific IgE

    Children with atopic dermatitis (AD) are at risk of developing allergy. Alongside clinical history, testing modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) and recently, microarra...

    Ru-Xin Foong, Graham Roberts, Adam Tobias Fox and George du Toit

    Clinical and Molecular Allergy 2016 14:8

    Published on: 19 August 2016

  14. Research

    Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice

    Airborne allergens can induce an immunological chronic disease characterized by airway hyper responsiveness and inflammation, mediated by exaggerated Th2 immune response. Allergen-specific immunotherapy (AIT) ...

    Claudia Petrarca, Emanuela Clemente, Valentina Amato, Alessia Gatta, Sara Cortese, Alessia Lamolinara, Cosmo Rossi, Stefania Zanotta, Gianni Mistrello, Roberto Paganelli and Mario Di Gioacchino

    Clinical and Molecular Allergy 2016 14:7

    Published on: 5 August 2016

  15. Review

    Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay

    Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the presence of antiphospholipid antibodies (aPL) in subjects presenting with thrombosis and/or pregnancy loss. The currently used cl...

    Savino Sciascia, Simone Baldovino, Karen Schreiber, Laura Solfietti, Massimo Radin, Maria J. Cuadrado, Elisa Menegatti, Doruk Erkan and Dario Roccatello

    Clinical and Molecular Allergy 2016 14:6

    Published on: 15 July 2016

  16. Commentary

    Appropriateness in allergic respiratory diseases health care in Italy: definitions and organizational aspects

    In a historical period in which sustainability of the National Health Service is mandatory because of the international economical situation, the limited available resources at national level and the tendency ...

    Carlo Lombardi, Eleonora Savi, Maria Teresa Costantino, Enrico Heffler, Manlio Milanese, Giovanni Passalacqua and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2016 14:5

    Published on: 19 April 2016

  17. Review

    Quality of life in patients with food allergy

    Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in t...

    Darío Antolín-Amérigo, Luis Manso, Marco Caminati, Belén de la Hoz Caballer, Inmaculada Cerecedo, Alfonso Muriel, Mercedes Rodríguez-Rodríguez, José Barbarroja-Escudero, María José Sánchez-González, Beatriz Huertas-Barbudo and Melchor Alvarez-Mon

    Clinical and Molecular Allergy 2016 14:4

    Published on: 17 February 2016

  18. Research

    Comparing the ability of molecular diagnosis and CAP-inhibition in identifying the really causative venom in patients with positive tests to Vespula and Polistes species

    Cross-reactivity among Hymenoptera venoms is an important issue when prescribing venom immunotherapy (VIT). Using all venoms eliciting a positive response results in treatment excess and unjustified cost incre...

    Eleonora Savi, Silvia Peveri, Elena Makri, Valerio Pravettoni and Cristoforo Incorvaia

    Clinical and Molecular Allergy 2016 14:3

    Published on: 8 February 2016

  19. Research

    Skin microbiota of first cousins affected by psoriasis and atopic dermatitis

    Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria ...

    Lorenzo Drago, Roberta De Grandi, Gianfranco Altomare, Paolo Pigatto, Oliviero Rossi and Marco Toscano

    Clinical and Molecular Allergy 2016 14:2

    Published on: 25 January 2016

  20. Research

    Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4

    Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involv...

    Letizia Lombardelli, Federica Logiodice, Maryse Aguerre-Girr, Ornela Kullolli, Herman Haller, Ysabel Casart, Alain Berrebi, Fatima-Ezzahra L’Faqihi-Olive, Valérie Duplan, Sergio Romagnani, Enrico Maggi, Daniel Rukavina, Philippe Le Bouteiller and Marie-Pierre Piccinni

    Clinical and Molecular Allergy 2016 14:1

    Published on: 21 January 2016

  21. Research

    Determinants of venom-specific IgE antibody concentration during long-term wasp venom immunotherapy

    Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE ch...

    Valerio Pravettoni, Marta Piantanida, Laura Primavesi, Stella Forti and Elide A. Pastorello

    Clinical and Molecular Allergy 2015 13:29

    Published on: 15 December 2015

  22. Research

    Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients

    In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlat...

    Carina Gabriela Uasuf, Danilo Villalta, Maria Elisabetta Conte, Caterina Di Sano, Maria Barrale, Vincenzo Cantisano, Elisabetta Pace, Mark Gjomarkaj, Sebastiano Gangemi and Ignazio Brusca

    Clinical and Molecular Allergy 2015 13:30

    Published on: 2 December 2015

  23. Research

    Choosing wisely in Allergology: a Slow Medicine approach to the discipline promoted by the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC)

    One of the main problem health care systems are facis is the mis-use and over-use of medical resources (including useless exams, surgical interventions, medical treatments, screening procedures…) which may lea...

    Enrico Heffler, Massimo Landi, Silvana Quadrino, Cristoforo Incorvaia, Stefano Pizzimenti, Sandra Vernero, Nunzio Crimi, Giovanni Rolla and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2015 13:28

    Published on: 20 November 2015

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