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Table 3 Immunostimulating effects of metal nanoparticles on cells of the immune system

From: Engineered metal based nanoparticles and innate immunity

NPs

Cells

Effects

Ref

AgNPs

Human PBMCs

Size dependent IL-1β production (inverse correlation)

[39]

TiO2NPs AgNPs ZnONPs

Lung macrophages, dendritic cells, basophils, neutrophils and eosinophils

Increase of inflammatory and Th cell activating cytokines (IL-2, IL-4, IL-6, CINC-1, IL-10, TNF-α)

[77–79, 86, 87]

Fe2O3 NiNP CoNPs PdNPs

Human peripheral monocytes

Increase of Th1 cytokines

[24, 41, 82–84]