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  1. Research

    Selecting optimal second-generation antihistamines for allergic rhinitis and urticaria in Asia

    Allergic diseases are on the rise in many parts of the world, including the Asia–Pacific (APAC) region. Second-generation antihistamines are the first-line treatment option in the management of allergic rhinit...

    Marysia Tiongco Recto, Ma. Teresita Gabriel, Kanokvalai Kulthanan, Pongsakorn Tantilipikorn, Derrick Chen-Wee Aw, Tak Hong Lee, Ch’ng Chin Chwen, Somasundran Mutusamy, Nguyen Trong Hao, Vo Thanh Quang and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2017 15:19

    Published on: 1 November 2017

  2. Research

    High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi

    IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The...

    Jenny van Odijk, Sigrid Sjölander, Peter Brostedt, Magnus P. Borres and Hillevi Englund

    Clinical and Molecular Allergy 2017 15:18

    Published on: 1 November 2017

  3. Review

    How to fit allergen immunotherapy in the elderly

    Asthma, allergic rhinitis (AR) and atopic dermatitis are very common in young people, but in the latest decades it was increasingly recognized that also individuals of higher ages, including the population ove...

    Erminia Ridolo, Anti Rogkakou, Maria Teresa Ventura, Irene Martignago, Cristoforo Incorvaia, Gabriele Di Lorenzo and Giovanni Passalacqua

    Clinical and Molecular Allergy 2017 15:17

    Published on: 6 October 2017

  4. Review

    Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature

    Anticonvulsant hypersensitivity syndrome represents a rare but potentially fatal kind of adverse drug reaction. This clinical picture often hampers the flexibility with which alternative anticonvulsants or eve...

    Fabrizio De Luca, Laura Michelina Losappio, Corrado Mirone, Jan Walter Schroeder, Antonella Citterio, Maria Gloria Aversano, Joseph Scibilia and Elide Anna Pastorello

    Clinical and Molecular Allergy 2017 15:16

    Published on: 4 October 2017

  5. Research

    A survey on the perception of allergy specialists about the reimbursed grass pollen tablets for seasonal allergic rhinitis in Italy

    Sublingual immunotherapy (SLIT) is a feasible option to classical subcutaneous immunotherapy to treat respiratory allergy and is increasingly prescribed in Europe. However, the lack of reimbursement may limit ...

    Ilaria Massaro, Oliviero Rossi, Cristoforo Incorvaia and Carlo Lombardi

    Clinical and Molecular Allergy 2017 15:15

    Published on: 15 August 2017

  6. Case Report

    Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature

    Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity react...

    Malik Ghannam, Shaden Mansour, Aya Nabulsi and Qusay Abdoh

    Clinical and Molecular Allergy 2017 15:14

    Published on: 15 June 2017

  7. Review

    Association between HMGB1 and asthma: a literature review

    Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characte...

    Egidio Imbalzano, Sebastiano Quartuccio, Eleonora Di Salvo, Teresa Crea, Marco Casciaro and Sebastiano Gangemi

    Clinical and Molecular Allergy 2017 15:12

    Published on: 14 June 2017

  8. Research

    The soft computing-based approach to investigate allergic diseases: a systematic review

    Early recognition of inflammatory markers and their relation to asthma, adverse drug reactions, allergic rhinitis, atopic dermatitis and other allergic diseases is an important goal in allergy. The vast majori...

    Gennaro Tartarisco, Alessandro Tonacci, Paola Lucia Minciullo, Lucia Billeci, Giovanni Pioggia, Cristoforo Incorvaia and Sebastiano Gangemi

    Clinical and Molecular Allergy 2017 15:10

    Published on: 13 April 2017

  9. Review

    Hypersensitivity reactions due to black henna tattoos and their components: are the clinical pictures related to the immune pathomechanism?

    Hypersensitivity to para-phenylenediamine (PPD) and related compounds induced by temporary black henna tattoos has become a serious health problem worldwide. Different patterns of sensitization with various cl...

    Gianfranco Calogiuri, Elisabetta Di Leo, Lavjay Butani, Stefano Pizzimenti, Cristoforo Incorvaia, Luigi Macchia and Eustachio Nettis

    Clinical and Molecular Allergy 2017 15:8

    Published on: 10 April 2017

  10. Commentary

    SANI-Severe Asthma Network in Italy: a way forward to monitor severe asthma

    Even if severe asthma (SA) accounts for 5–10% of all cases of the disease, it is currently a crucial unmet need, owing its difficult clinical management and its high social costs. For this reason several netwo...

    G. Senna, M. Guerriero, P. L. Paggiaro, F. Blasi, M. Caminati, E. Heffler, M. Latorre and G. W. Canonica

    Clinical and Molecular Allergy 2017 15:9

    Published on: 10 April 2017

  11. Research

    Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study

    Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sub...

    I. Djuric-Filipovic, Marco Caminati, D. Filipovic, C. Salvottini and Z. Zivkovic

    Clinical and Molecular Allergy 2017 15:7

    Published on: 3 April 2017

  12. Review

    Hypersensitivity pneumonitis: a complex lung disease

    Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitiu...

    Gian Galeazzo Riario Sforza and Androula Marinou

    Clinical and Molecular Allergy 2017 15:6

    Published on: 7 March 2017

  13. Research

    Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy

    Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physicia...

    Mizuho Nagao, Magnus P. Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel and Takao Fujisawa

    Clinical and Molecular Allergy 2017 15:4

    Published on: 3 March 2017

  14. Case Report

    Avoiding misdiagnosis in patients with dyspnea and wheezing: a case report illustrating the clinical implications of fixation error

    Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may ...

    Fabiano Di Marco, Giuseppe Francesco Sferrazza Papa, Dejan Radovanovic and Pierachille Santus

    Clinical and Molecular Allergy 2017 15:3

    Published on: 8 February 2017

  15. Review

    Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms

    Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is pa...

    Maria Teresa Ventura, Nicola Scichilone, Roberto Paganelli, Paola Lucia Minciullo, Vincenzo Patella, Matteo Bonini, Giovanni Passalacqua, Carlo Lombardi, Livio Simioni, Erminia Ridolo, Stefano R. Del Giacco, Sebastiano Gangemi and Giorgio Walter Canonica

    Clinical and Molecular Allergy 2017 15:2

    Published on: 3 February 2017

  16. Research

    Clinical management, expectations, and satisfaction of patients with moderate to severe allergic rhinoconjunctivitis treated with SQ-standardized grass-allergen tablet under routine clinical practice conditions in Spain

    Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX® is the most documented product in terms of safety and efficacy. T...

    Tomás Chivato, Pedro Álvarez-Calderón, Carmen Panizo, Ricardo Abengozar, César Alías, Ali Al-Baech, José Arias-Irigoyen, M. José Caballero, Lluis Conill, Silvia de Miguel, Rafael Laguna, Joan Martínez-Benazet, Francisco Matoses, Jose Camilo Martínez-Alonso, Lourdes Mendizábal, Celsa Pérez-Carral…

    Clinical and Molecular Allergy 2017 15:1

    Published on: 6 January 2017

  17. Review

    Different clinical allergological features of Taenia solium infestation

    The tapeworm Taenia (T.) solium can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tis...

    Paola Lucia Minciullo, Antonio Cascio, Stefania Isola and Sebastiano Gangemi

    Clinical and Molecular Allergy 2016 14:18

    Published on: 7 December 2016

  18. Review

    Eosinophilic disorders of the gastro-intestinal tract: an update

    Eosinophilic diseases of the gastrointestinal tract, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), are rare chronic pathologies of the digestive system, with an immuno-mediat...

    Erminia Ridolo, Valerie Melli, Gianluigi De’ Angelis and Irene Martignago

    Clinical and Molecular Allergy 2016 14:17

    Published on: 1 December 2016

  19. Research

    Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients

    CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that ch...

    Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato and Lorenzo Cosmi

    Clinical and Molecular Allergy 2016 14:16

    Published on: 8 November 2016

  20. Research

    HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4

    The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal enviro...

    Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Antonio Lobasso, Filomena Napolitano, Francescopaolo Granata, Carmine Selleri and Amato de Paulis

    Clinical and Molecular Allergy 2016 14:15

    Published on: 1 November 2016

  21. Case Report

    Mastocytosis and systemic sclerosis: a clinical association

    Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involveme...

    Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Donatella Sangari, Santa Cirmi, Roneka L. Ravenell, Michele Navarra, Gianfilippo Bagnato and Sebastiano Gangemi

    Clinical and Molecular Allergy 2016 14:13

    Published on: 11 October 2016

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