Table 1 12-Step desensitization protocol with 1695 mg Ifosfamide + 1695 mg Mesna
From: Cutaneous reaction to ifosfamide plus mesna treated with desensitization challenge: a case report
Domiciliary Allergy premedication (Start 2 days before) | - Singulair 10 mg |
- Aspirine 300 mg | |
- Ebastine 10 mg | |
- Ranitidine 150 mg | |
Hospital Oncology premedication | - Dexamathasone 8 mg intravenous |
- Ganisetron 1 mg oral | |
Hospital Allergy premedication | - Polaramine 1 vial intravenous |
- Ranitidine 50 mg intravenous | |
- Diazepam 5 mg sublingual |
3 dilutions of the total doses with 1000 ml 0.9% NaCl | Total doses | mg/ml | |
|---|---|---|---|
Solution 1/100 | 16.95 | 0.01695 | |
Solution 1/10 | 169.5 | 0.1695 | |
Solution 1/1* | 1691.665 | 1.691665 | |
Rate (ml/h) | Time (min) | Vol. Infused (ml) | Doses (mg) | |
|---|---|---|---|---|
Solution 1/100 | 2 | 15 | 0.5 | 0.008 |
5 | 15 | 1.25 | 0.021 | |
10 | 15 | 2.5 | 0.042 | |
20 | 15 | 5 | 0.085 | |
Total = | 60 | 9.25 | 0.157 | |
Solution 1/10 | 5 | 15 | 1.25 | 0.212 |
10 | 15 | 2.5 | 0.424 | |
20 | 15 | 5 | 0.848 | |
40 | 15 | 10 | 1.695 | |
Total = | 60 | 18.75 | 3.178 | |
Solution 1/1 | 10 | 15 | 2.5 | 4.238 |
20 | 15 | 5 | 8.475 | |
40 | 15 | 10 | 16.950 | |
80 | 15 | 20 | 33.900 | |
132** | 437 | 960.53 | 1628.103 | |
Total = | 617 | 1000 | 1691.665 | |
Total mg | 1695 |