Fig. 2

TLR7 within the X chromosome and its principal characteristics in the anti-viral response. The Toll-like Receptor 7 gene (TLR7) is located in the pseudo-autosomal region 1 of the X chromosome (p22.2). The principal characteristics of TLR7 are summarized on the right. ACE2: Angiotensin I Converting Enzyme 2; BTK: Bruton Tyrosine Kinase; CD40LG: CD40 Ligand; CFP: Complement Factor Properdin; CYBB: Cytochrome B-245 Beta Chain; CXCR3: C-X-C Motif Chemokine Receptor 3; GATA1: GATA Binding Protein 1; IKBKG: Inhibitor of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma; IL13RA1: Interleukin 13 Receptor Subunit Alpha 1; IL2RG:Interleukin 2 Receptor Subunit Gamma; IARK1: Interleukin 1 Receptor Associated Kinase 1; IRF Interferon regulatory factors; FOXP3: Forkhead Box P3; LGP2 laboratory of genetic and physiology 2; MAPK mitogen-activated protein kinase; MDA5 melanoma differentiation-associated protein 5; MyD88 myeloid differentiation primary response gene 88; NFκB nuclear factor kappa-light-chain-enhancer of activated B cells; pDCs plasmacytoid dendritic cells; RIG-I retinoic acid-inducible gene I; TLR8: Toll Like Receptor 8; WAS: Wiskott-Aldrich Syndrome