From: Role of genetic variations of chitinase 3-like 1 in bronchial asthmatic patients
rs1214194 genotype | GG (n = 170) | GA (n = 157) | AA (n = 41) | P value |
---|---|---|---|---|
Age, years | 57.8 ± 1.2 | 57.7 ± 1.3 | 58.4 ± 2.7 | NS |
Height, cm | 158.8 ± 0.7 | 159.0 ± 0.7 | 157.7 ± 1.5 | NS |
Body weight, kg | 60.5 ± 1.9 | 59.6 ± 1.0 | 59.1 ± 1.9 | NS |
Sex, n (%) | 71 men (42) | 71 men (45) | 15 men (37) | NS |
Age of onset, years | 43.5 ± 1.6 | 43.2 ± 1.7 | 34.2 ± 3.3 | 0.032 |
Eosinophil count/μL | 315.6 ± 21.7 | 310.6 ± 23.4 | 331.7 ± 46.1 | NS |
IgE level, IU/mL | 473.7 ± 97.5 | 504.4 ± 101.2 | 235.7 ± 199.2 | NS |
GINA asthma severity, n (%) | ||||
 Mild | 35 (20.6) | 34 (21.7) | 4 (9.8) | – |
 Moderate | 70 (41.2) | 61 (38.9) | 18 (43.9) | – |
 Severe | 65 (38.2) | 62 (39.5) | 19 (46.3) | – |
Pulmonary function | ||||
 %FVC | 104.0 ± 2.6 | 104.0 ± 2.4 | 97.2 ± 5.9 | NS |
 FEV1, L | 2.3 ± 0.1 | 2.3 ± 0.1 | 2.1 ± 0.2 | NS |
 FEV1/FVC, % | 72.4 ± 0.9 | 72.2 ± 1.0 | 70.9 ± 1.8 | NS |
 %FEV1 | 99.6 ± 2.0 | 98.8 ± 1.8 | 87.9 ± 3.6 | 0.04 |
  Mild | 106.7 ± 4.3 | 102.7 ± 3.8 | 91.0 ± 11.8 | – |
  Moderate | 103.1 ± 3.0 | 99.3 ± 2.8 | 89.5 ± 5.6 | – |
  Severe | 92.0 ± 3.1 | 95.1 ± 3.8 | 85.8 ± 5.4 | – |
 Equivalent FP CFC dose (μg/day) | 325.6 ± 20.8 | 363.1 ± 22.3 | 432.1 ± 44.1 | NS |