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Table 1 Sublingual immunotherapy preparations available for children so far that have been evaluated as single products in clinical trials

From: A critical appraisal on AIT in childhood asthma

Name

Producer

Composition

Trial population evaluated

Acarizax® (MK-8237)

ALK-Abelló, Hørsholm, Denmark

Standardised allergen extract from house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae

House dust mite-induced Allergic rhinoconjunctivitis with or without coexisting asthma in patients > 18 years old; approved for adolescents in certain countries

Grazax®/Grastek®

ALK-Abelló, Hørsholm, Denmark

Standardised allergen extract of Timothy grass pollen (Phleum pratense)

Grass pollen-induced rhinitis and allergic conjunctivitis in adults and children 5 years or older

Miticure® (MK-8237)

Torii Pharmaceutical Co., Japan)

Extract from the house dust mites Dermatophagoides (D.) pteronyssinus and Dermatophagoides farinae

Adults and children aged ≥ 12 years

Oralair®

Stallergenes, France

Mixture of natural allergens of pollens from five cross-reacting grasses (Dactylis glomerata L., Anthoxanthum odoratum L., Lolium perenne L., Poa pratensis L. and P. pratense L.)

In Europe and the US for the treatment of grass pollen induced allergic rhinoconjunctivitis in children > 5 years (> 10 years in the US) and adults

Purethal® Mites

Hal Allergy,

Mite extract mixture chemically modified with glutaraldehyde and adsorbed onto aluminum hydroxide

43 asthmatic children (6–14 years) with mites sensitization

Staloral®

Stallergenes, France

D. pteronyssinus + D. farinae extrac

Patients aged 6–18 with allergic rhinitis with or without allergic asthma