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Table 1 Sublingual immunotherapy preparations available for children so far that have been evaluated as single products in clinical trials

From: A critical appraisal on AIT in childhood asthma

Name Producer Composition Trial population evaluated
Acarizax® (MK-8237) ALK-Abelló, Hørsholm, Denmark Standardised allergen extract from house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae House dust mite-induced Allergic rhinoconjunctivitis with or without coexisting asthma in patients > 18 years old; approved for adolescents in certain countries
Grazax®/Grastek® ALK-Abelló, Hørsholm, Denmark Standardised allergen extract of Timothy grass pollen (Phleum pratense) Grass pollen-induced rhinitis and allergic conjunctivitis in adults and children 5 years or older
Miticure® (MK-8237) Torii Pharmaceutical Co., Japan) Extract from the house dust mites Dermatophagoides (D.) pteronyssinus and Dermatophagoides farinae Adults and children aged ≥ 12 years
Oralair® Stallergenes, France Mixture of natural allergens of pollens from five cross-reacting grasses (Dactylis glomerata L., Anthoxanthum odoratum L., Lolium perenne L., Poa pratensis L. and P. pratense L.) In Europe and the US for the treatment of grass pollen induced allergic rhinoconjunctivitis in children > 5 years (> 10 years in the US) and adults
Purethal® Mites Hal Allergy, Mite extract mixture chemically modified with glutaraldehyde and adsorbed onto aluminum hydroxide 43 asthmatic children (6–14 years) with mites sensitization
Staloral® Stallergenes, France D. pteronyssinus + D. farinae extrac Patients aged 6–18 with allergic rhinitis with or without allergic asthma