Skip to main content

Table 3 Clinical and laboratory data at the diagnosis

From: Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature

 

P1

P2

P3

P4

P5

P6

Eosinophils (%)

12

39

5.1

4.6

2.3

2.2

Leukocytes (109/L)

34.67

40.23

15.0

16.0

5.6

4.7

Atypical lymphocytes

+

+

GOT/GPT (IU/L)

1034/906

1068/960

56/50

89/63

510/702

503/731

CRP (mg/dL)

9.2

9.6

13.6

11.3

1.1

1.0

LDH (IU/L)

1780

1890

1230

1360

1450

423

HHV-6 infection

+

+

HCV, HBV, CMV, HSV-1 and -2, EBV, HIV infection

HSV-2

 

Blood cultures

Candida albicans

MRSA

Staphylococcus capitis

MRSA

Urine cultures

Enterococcus faecalis

ANA

Skin biopsy

Acantholytic cells, skin detachment, mild lymphocytic infiltration

ND

ND

Apoptotic keratinocytes, spongiosis, subepidermal blister and dermal inflammatory infiltrate

Dermal infiltrate of lymphocytes and monocytes

Apoptotic keratinocytes, epidermal necrosis and dermal infiltrate of lymphocytes

  1. CRP: C-reactive protein, GOT: glutamate oxaloacètique transaminase, GPT: glutamane pyruvate transaminase, LDH: lactate dehydrogenase, ANA: antinuclear antibodies, MRSA: methicillin-resistant Staphylococcus aureus, ND: not done, +: positive, −: negative