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Table 3 Clinical and laboratory data at the diagnosis

From: Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature

  P1 P2 P3 P4 P5 P6
Eosinophils (%) 12 39 5.1 4.6 2.3 2.2
Leukocytes (109/L) 34.67 40.23 15.0 16.0 5.6 4.7
Atypical lymphocytes + +
GOT/GPT (IU/L) 1034/906 1068/960 56/50 89/63 510/702 503/731
CRP (mg/dL) 9.2 9.6 13.6 11.3 1.1 1.0
LDH (IU/L) 1780 1890 1230 1360 1450 423
HHV-6 infection + +
HCV, HBV, CMV, HSV-1 and -2, EBV, HIV infection HSV-2  
Blood cultures Candida albicans MRSA Staphylococcus capitis MRSA
Urine cultures Enterococcus faecalis
ANA
Skin biopsy Acantholytic cells, skin detachment, mild lymphocytic infiltration ND ND Apoptotic keratinocytes, spongiosis, subepidermal blister and dermal inflammatory infiltrate Dermal infiltrate of lymphocytes and monocytes Apoptotic keratinocytes, epidermal necrosis and dermal infiltrate of lymphocytes
  1. CRP: C-reactive protein, GOT: glutamate oxaloacètique transaminase, GPT: glutamane pyruvate transaminase, LDH: lactate dehydrogenase, ANA: antinuclear antibodies, MRSA: methicillin-resistant Staphylococcus aureus, ND: not done, +: positive, −: negative