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Table 1 Studies assessing the association between HMGB1 and asthma

From: Association between HMGB1 and asthma: a literature review

Authors Manuscript title Year Humans Animals Tissue HMGB1 level Laboratory test Functional or imaging test
Watanabe Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients 2011 X Sputum RAGE Spirometry
Hou High mobility group protein B1 (HMGB1) in asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls 2011 X Sputum plasma Spirometry
Zhou HMGB1 and RAGE levels in induced sputum correlate with asthma severity and neutrophil percentage 2012 X Sputum RAGE Spirometry
Shim The role of high-mobility group box-1 (HMGB1) in the pathogenesis of asthma 2012 X X Sputum (human) lung tissue, BAL (animal) IL-4, IL-5, IL-13, and GM-CSF
Sukkar Soluble RAGE is deficient in neutrophilic asthma and COPD 2012 X Sputum serum RAGE; SAA
Lee Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma 2013 X Mediastinal lymph nodes and lungs tissue BAL
Zhang Recombinant HMGB1 A box protein inhibits Th17 responses in mice with neutrophilic asthma by suppressing dendritic cell-mediated Th17 polarization 2014 X Lung tissue Whole-body plethysmography
Zhang Anti-HMGB1 neutralizing antibody ameliorates neutrophilic airway inflammation by suppressing dendritic cell-mediated Th17 polarization. 2014 X Bone marrow
Lung tissue
Tang Ethyl pyruvate decreases airway neutrophil infiltration partly through a high mobility group box 1-dependent mechanism in a chemical-induced murine asthma model 2014 X BALF
Lung tissue
Barometric plethysmographic chamber
Ma High mobility group box 1: a novel mediator of Th2-type response-induced airway inflammation of acute allergic asthma 2015 X BAL
Lung tissue
IL-4, IL-5, IL-6, IL-8, IL-17, IFN-γ, GATA3 Measuring airway resistance of lung (RL) and Cdyn via MCh challenge
Ojo High-mobility group box 1 promotes extracellular matrix synthesis and wound repair in human bronchial epithelial cells 2015 X Cell culture E-cadherin, integrins, extra cellular matrix proteins
Yao Chicken IgY facilitates allergic airway inflammation in a chemical-induced murine asthma model by potentiating IL-4 release 2015   X Lung tissue IL-4, IgY
Cuppari Sputum high mobility group box-1 in asthmatic children: a noninvasive sensitive biomarker reflecting disease status 2015 x Sputum Serum total IgE levels Spirometry
Qiao Effect of different 1,25-(OH)2D3 doses on high mobility group box1 and toll-like receptors 4 expression in lung tissue of asthmatic mice 2015 X Lung tissue HMGB1 and TLR4
Liang J Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model 2015 X Lung tissue
Lymph node cells
Serum IgE Barometric plethysmo-graphic chamber
Liang Y HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2 2015 X Primary culture of human bronchial epithelial cells TNF-a, TSLP, MMP-9, VEGF
Shim Eosinophils modulate CD4(+) T cell responses via high mobility group box-1 in the pathogenesis of asthma 2015 X Lung tissue IL-4 and IL-5
Hou HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts 2015 X BALF
Lung tissue
IFN-γ, IL-5, IL-4, IL-13, IL-1β, TNF-α, VEGF, active-TGF-β1, MMP-9
Ullah Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation 2014 X Lung tissue TLR4-RAGE