Table 1 Studies assessing the association between HMGB1 and asthma
From: Association between HMGB1 and asthma: a literature review
Authors | Manuscript title | Year | Humans | Animals | Tissue | HMGB1 level | Laboratory test | Functional or imaging test |
|---|---|---|---|---|---|---|---|---|
Watanabe | Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients | 2011 | X | – | Sputum | ≫ | RAGE | Spirometry |
Hou | High mobility group protein B1 (HMGB1) in asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls | 2011 | X | – | Sputum plasma | ≫ | – | Spirometry |
Zhou | HMGB1 and RAGE levels in induced sputum correlate with asthma severity and neutrophil percentage | 2012 | X | – | Sputum | ≫ | RAGE | Spirometry |
Shim | The role of high-mobility group box-1 (HMGB1) in the pathogenesis of asthma | 2012 | X | X | Sputum (human) lung tissue, BAL (animal) | ≫ | IL-4, IL-5, IL-13, and GM-CSF | – |
Sukkar | Soluble RAGE is deficient in neutrophilic asthma and COPD | 2012 | X | – | Sputum serum | ≫ | RAGE; SAA | – |
Lee | Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma | 2013 | – | X | Mediastinal lymph nodes and lungs tissue BAL | ≫ | – | – |
Zhang | Recombinant HMGB1 A box protein inhibits Th17 responses in mice with neutrophilic asthma by suppressing dendritic cell-mediated Th17 polarization | 2014 | – | X | Lung tissue | ≫ | – | Whole-body plethysmography |
Zhang | Anti-HMGB1 neutralizing antibody ameliorates neutrophilic airway inflammation by suppressing dendritic cell-mediated Th17 polarization. | 2014 | – | X | Bone marrow BALF Lung tissue | ≫ | – | – |
Tang | Ethyl pyruvate decreases airway neutrophil infiltration partly through a high mobility group box 1-dependent mechanism in a chemical-induced murine asthma model | 2014 | – | X | BALF Lymphnodes Lung tissue | ≫ | – | Barometric plethysmographic chamber |
Ma | High mobility group box 1: a novel mediator of Th2-type response-induced airway inflammation of acute allergic asthma | 2015 | – | X | BAL Lung tissue | ≫ | IL-4, IL-5, IL-6, IL-8, IL-17, IFN-γ, GATA3 | Measuring airway resistance of lung (RL) and Cdyn via MCh challenge |
Ojo | High-mobility group box 1 promotes extracellular matrix synthesis and wound repair in human bronchial epithelial cells | 2015 | X | – | Cell culture | – | E-cadherin, integrins, extra cellular matrix proteins | – |
Yao | Chicken IgY facilitates allergic airway inflammation in a chemical-induced murine asthma model by potentiating IL-4 release | 2015 | X | Lung tissue | ≫ | IL-4, IgY | – | |
Cuppari | Sputum high mobility group box-1 in asthmatic children: a noninvasive sensitive biomarker reflecting disease status | 2015 | x | – | Sputum | ≫ | Serum total IgE levels | Spirometry |
Qiao | Effect of different 1,25-(OH)2D3 doses on high mobility group box1 and toll-like receptors 4 expression in lung tissue of asthmatic mice | 2015 | – | X | Lung tissue | ≫ | HMGB1 and TLR4 | – |
Liang J | Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model | 2015 | – | X | Lung tissue Lymph node cells BAL | ≫ | Serum IgE | Barometric plethysmo-graphic chamber |
Liang Y | HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2 | 2015 | X | – | Primary culture of human bronchial epithelial cells | ≫ | TNF-a, TSLP, MMP-9, VEGF | – |
Shim | Eosinophils modulate CD4(+) T cell responses via high mobility group box-1 in the pathogenesis of asthma | 2015 | – | X | Lung tissue | ≫ | IL-4 and IL-5 | – |
Hou | HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts | 2015 | – | X | BALF Lung tissue | ≫ | IFN-γ, IL-5, IL-4, IL-13, IL-1β, TNF-α, VEGF, active-TGF-β1, MMP-9 | – |
Ullah | Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation | 2014 | – | X | Lung tissue | ≫ | TLR4-RAGE | – |