Table 1 Most common culprit drugs in SJS/TEN and EM
Drugs associated with Stevens–Johnson syndrome and toxic epidermal necrolisis | ||||
|---|---|---|---|---|
| Â | Risk a priori | Prevalence in SJS/TEN registries | Extension of employment | Probable/very probable causality in multicenter trials |
Allopurinol | Very high | Very high | Widespread | Frequent |
Anticonvulsants Carbamazepine Lamotrigine Phenobarbital Phenytoin Valproic Acid | Very high | Very high | Widespread | Frequent |
NSAIDs | Variable | High | Widespread | Variable |
Oxicam NSAIDs | Very high | Low | Limited | Frequent |
Sulfonamides Cotrimoxazole Sulfadiazine Sulfasalazine Others | High | High | Widespread | Frequent |
Non-sulfa antibiotics | ||||
Aminopenicillins | Low | Medium | Widespread | Non frequent |
Cephalosporins | Medium | Medium | Widespread | Non frequent |
Quinolones | Medium | Medium | Widespread | Moderately frequent |
Macrolides | Medium | Medium | Widespread | No |
Tetraciclines | Medium | Low | Medium | Frequent |
Nevirapine | High | High | Limited | Frequent |
Pantoprazole | Unknown | Low | Widespread | ND |
Paracetamol | Low | High | Widespread | Non freqeuent |
Furosemide | Low | Variable | Widespread | ND |
Sertraline | High | Low | Medium | Frequent |
Drugs associated with erythema multiforme | ||||
Sulfonamides | ||||
NSAIDs | ||||
Anticonvulsants | ||||
Antibiotics (mainly penicillins) | ||||