Table 1 APS classification criteria, modified from Miyakis et al. [5]
Vascular thrombosis: | ≥1 Clinical episode of arterial, venous or small vessel thrombosis. Thrombosis must be objectively confirmed. For histopathological confirmation, thrombosis must be present without inflammation of the vessel wall |
Pregnancy morbidity: | 1. ≥1 Unexplained death of a morphologically normal fetus ≥10 weeks of gestation 2. ≥1 Premature delivery of a morphologically normal fetus <34 weeks gestation because of: Severe pre-eclampsia or eclampsia defined according to standard definition Recognised features of placental insufficiency 3. ≥3 Unexplained consecutive miscarriages <10 weeks gestation, with maternal and paternal factors (anatomic, hormonal or chromosomal abnormalities) excluded |
Laboratory criteria: | The presence of antiphospholipid antibodies (aPL), on two or more occasions at least 12 weeks apart and no more than 5 years prior to clinical manifestations, as demonstrated by ≥1 of the following Presence of lupus anticoagulant in plasma Medium to high-titre anticardiolipin antibodies (>40 GPL or MPL, or >99th ‰) of IgG or IgM isoforms Anti-β2 glycoprotein-I antibody (anti-β2GPI) of IgG or IgM present in plasma |