From: Engineered metal based nanoparticles and innate immunity
NP | Cells | Effect | Dose/Diameter | Ref |
---|---|---|---|---|
CoNP | Monocyte/Macrophages | -Activation of the innate immune response | Â | [26] |
-Release of inflammatory cytokines through TLR-4 | ||||
TiO2NP ZnONP | Human lymphocytes | -No alterations of MDDC phenotype | 10 μg/mL | [30] |
ZnONP | Human lymphocytes | -Down regulation of CD16 on NK-cells | subtoxic | [30] |
AuNP | Macrophages | -Reduction of macrophage response against pathogens | 4-45Â nm | [32] |
-Accumulation of NPs in the lysosomes | ||||
-Inhibition of TRL9 function | ||||
-Inhibition of TNF-α production |