Table 1 Double blind randomized trials in seasonal AR

Kuna P et al. [24]

683

14 days

Bilastine 20 mg Cetirizine 10 mg Placebo

The mean TSS-AUC_{0_14} days (score_day) was reduced in bilastine and cetirizine groups to a similar and significantly greater extent, compared with placebo (P < 0.001). Bilastine and cetirizine were comparable and significantly superior to placebo for all secondary outcomes

Significantly fewer patients in the bilastine-treated group experienced somnolence (P < 0.001) and fatigue (P = 0.02) than patients in the cetirizine-treated group.

Bachert C et al. [23]

721

14 days

Bilastine 20 mg Desloratadine 5 mg Placebo

The AUC of TSS was decreased to a significantly greater extent in the bilastine group compared with placebo group (P < 0.001). Total RQLQ score was significantly reduced from baseline by a value of 1.6 (1.2; 1.8–1.4) in the bilastine treated group compared with a value of 1.3 (1.3; 1.5–1.1) in the placebo-treated group (P < 0.005)

Safety profile of bilastine and desloratadine were comparable to placebo.