Figure 2

Effect of anti-IgE therapy on allergen specific T cell proliferation. (A) Allergen specific CD4 T cell proliferation was measured by calculating the percentage of CFSE^low cells and the results compared both at baseline and at completion of a 16-week trial of omalizumab. (B) Example of an allergen dose response to peanut Ag for subject 2, performed at baseline (circles) and at study completion (squares). (C) The EC₅₀ for allergen proliferation was compared at baseline and at study completion. (D) The precursor frequency of allergen specific T cells was determined by CFSE dye dilution and compared at baseline and at study completion. Each color/symbol combination represents one subject and one allergen; results in A and D include two allergens examined for each subject.