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Table 2 Normal reference values for lymphocyte subsets in healthy adults determined by flow cytometry

From: Relevance of laboratory testing for the diagnosis of primary immunodeficiencies: a review of case-based examples of selected immunodeficiencies

Lymphocyte subset 95% reference values
  18-55 years >55 years
CD45 0.99 - 3.15 thousand/uL 1.00 - 3.33 thousand/uL
CD3 677-2383 cells/μl 617-2254 cells/μl
CD4 424-1509 cells/μl 430-1513 cells/μl
CD8 169-955 cells/μl 101-839 cells/μl
CD19 99-527 cells/μl 31-409 cells/μl
CD16+56+ 101-678 cells/μl 110-657 cells/μl
CD3 59-83% 49-87%
CD4 31-59% 32-67%
CD8 12-38% 8-40%
CD19 6-22% 3-20%
CD16+56+ 6-27% 6-35%
  1. Data derived from 207 healthy adult male and female donors. Pediatric reference ranges for T, B and NK cells [147].