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Table 4 MPO release from neutrophils spontaneously and after C3b-stimulation (at 0 and 20 min) in allergic rhinitis and allergic asthma during pollen season and after nasal and bronchial challenge.

From: Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge

 

Spontaneous degranulation of MPO*

p-value

Stimulated degranulation of MPO*

p-value

 

(median, range)

increase 0-20 min

(median, range)

increase 0-20 min

 

0 min

20 min

 

0 min

20 min

 

Pollen season

      

Allergic rhinitis

2.12

2.45

0.81

2.84

15.9

0.008

 

(1.18 - 6.86)

(1.67 - 5.64)

 

(0.93 - 7.07)

(10.6 - 29.2)

 

Allergic asthma

2.25

2.50

0.74

3.05

17.6

0.018

 

(0.28 - 5.05)

(0.95 - 5.5)

 

(0.37 - 5.20)

(7.48 - 24.0)

 

Nasal challenge

      

Allergic rhinitis

2.61

3.16

0.68

2.93

14.9

0.043

 

(1.42 - 5.64)

(1.68 - 4.1)

 

(1.63 - 5.55)

(12.7 - 21.7)

 

Allergic asthma

2.21

3.31

0.018

2.35

18.4

0.018

 

(1.18 - 5.62)

(2.08 - 7.40)

 

(1.35 - 5.22)

(12.6 - 25.4)

 

Bronchial challenge

      

Allergic rhinitis

2.42

3.43

0.075

3.88

21.6

0.028

 

(2.17 - 2.92)

(2.24 - 4.93)

 

(2.14 - 6.00)

(16.8 - 27.3)

 

Allergic asthma

1.50

1.91

0.018

1.58

16.8

0.018

 

(0.84 - 2.3)

(1.36 - 2.48)

 

(0.71 - 2.96)

(13.1 - 23.3)

 
  1. *release of MPO in % of total cell content