Skip to main content

Table 1 Chronologic HIES scoring

From: Case report of a young child with disseminated histoplasmosis and review of hyper immunoglobulin e syndrome (HIES)

Age (mo)
Date
9
June, 2008
20
May, 2009
23
Aug, 2009
33
July, 2010
IgE score (IU/ml) 1 (187) 1 (371) 8 (1,011) 8 (1,106)
Skin abscess 0 0 0 2
Pneumonia 2 4 6 8
Lung anomalies 0 0 8 8
Fractures 4 4 4 8
Eczema 2 2 2 2
URIs/year 2 2 2 2
Candidiasis 1 1 1 1
Serious infections 0 0 0 4
Young age correction 7 5 5 3
NIH Score 19 19 36 46
Pneumonia N/A N/A 6 × 2.5 8 × 2.5
Pathologic fractures N/A N/A 4 × 3.33 8 × 3.33
STAT3 Score N/A N/A 28.32 46.64
  1. NIH score: unlikely, < 20; indeterminate, 20-40; suggestive of AD-HIES, > 40
  2. STAT3 score: possible, > 30+IgE ≥ 1,000 IU/ml, probable: > 30+IgE ≥ 1,000 IU/ml + low Th17 and/or positive F.Hx; definitive, > 30+IgE ≥ 1,000 IU/ml + heterozygous STAT3 mutation