Figure 3

Select up-regulated and down-regulated transcripts. The dendrogram shown highlights the variable expression that was observed at different timepoints for individual patients although collectively many transcripts were coordinately up or down-regulated over the course of the treatment. As above, the heat map is comparing pre-RIT and 1 week timepoints (columns 1 and 2 for each patient) versus 7 and 16 week timepoints (columns 3 and 4 for each patient). The 20 week PBMC sample for the first RIT patient (patient 1, column 5) is also shown. As in Figure 2, red indicates increased expression relative to the median of all samples, blue indicates decreased expression relative to the median of all samples and yellow indicates the median of all samples.