Heat maps of differentially expressed transcripts (≥2-fold change, p ≤ 0.05) after hierarchical clustering was performed to visualize up and down-regulated transcripts. The dendrogram shown compares pre-RIT and 1 week timepoints (columns 1 and 2 for each patient) versus 7 and 16 week timepoints (columns 3 and 4 for each patient). Included is a 20 week PBMC sample which was collected and processed for microarray for the first RIT patient only (patient 1, column 5). Overall there were 28 up-regulated transcripts and 16 down-regulated transcripts. In the dendrogram red indicates increased expression relative to the median of all samples, blue indicates decreased expression relative to the median of all samples and yellow indicates the median of all samples.