Figure 1
From: IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring
Similar parameters of OVA-induced AAD in wildtype or FcRn deficient mice. Five to 6 week old female C57BL/6J wildtype (B6AAD) or FcRn deficient (FcRn-/- AAD) mice were given two immunizations with OVA-Al(OH)3 followed by challenge for 7 days with 1% aerosolized OVA (daily exposure time 60 min). Parameters of disease severity measured were (A) serum IL-5 concentrations determined 24 hours after the first aerosol exposure; (B and C) serum OVA-specific Ig titers determined 24 hours after the last aerosol exposure; and (D) distribution of airway leukocytes determined by fluorescence flow cytometry as described in the Methods. Numbers of IL-33R+ or OVA-tetramer+ cells were of CD4+ and CD8+ T lymphocytes, respectively. Results expressed as means ± SEM and represent 5-6 mice per group. There were no statistical differences in disease parameters between groups. Similar parameters of disease were obtained in an independent experiment.