Table 1 Outline of additional immune deficiencies encountered in the patient group

#1

Total immunoglobulin G (IgG)

768 mg/dL

791-1643 mg/dL

IgG subclasses

Normal

Robust response to

pneumococcal serotype

6/14

> 8/14

Functional MBL pathway (C3b deposition assay)

2.02

> 5.1

#2

Immunoglobulin and complement levels

Normal

Functional MBL pathway (C3b deposition assay)

2.22

> 5.1

#3

C4 level

Mild deficiency (1 null allele out of 4)

4 functioning alleles

Functional MBL pathway (C3b deposition assay)

2.04

> 5.1

#4

Immunoglobulin and complement levels

Normal

C-reactive protein

10 mg/L

< 6 mg/L

Antinuclear antibody

1/8 (weakly positive)

< 1/8

Functional MBL pathway (C3b deposition assay)

2.10

> 5.1

#5

Immunoglobulin and complement levels

Normal

Functional MBL pathway (C3b deposition assay)

2.18

> 5.1

#6

IgG3

34 mg/dL

41-129 mg/dL

Functional MBL pathway (C3b deposition assay)

Not available