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Table 2 IL-4RA and IL-13 polymorphisms in children with Alternaria -sensitive moderate-severe asthma compared to Alternaria -sensitive mild asthma.

From: Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma

Study

Moderate-Severe

(60)

Mild

(49)

P

IL-4RA SNPs

   

   ile75val

83 (0.627)

57 (0.388)

0.005 (0.012)

   glu400ala

61 (0.390)

49 (0.265)

 

   cys431arg

15 (0.102)

22 (0.112)

 

   ser503pro

53 (0.347)

37 (0.214)

 

   gln576arg

75 (0.534)

59 (0.406)

 

IL-13 SNP

   

   arg110gln

31 (0.178)

37 (0.204)

 

75val/576arg

63

38

0.012

75val/110gln

31

17

 

75val/576arg/110gln

22

8

0.07

  1. Abbreviations: IL-4RA, IL-4 receptor alpha chain; SNP single nucleotide polymorphisms.
  2. Data presented as percentage (%) of patients and in parentheses, allele frequency.
  3. P value using Fisher's exact test.
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Clinical and Molecular Allergy

ISSN: 1476-7961

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