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Table 1 Demographics of children with Alternaria-sensitive moderate-severe asthma compared to Alternaria-sensitive mild asthma.

From: Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma

Study Moderate-Severe
(60)
Mild
(49)
P
Age, years 11 ± 4 10 ± 3  
Sex, % male/female 62/38 64/36  
White/Black/Hispanic, %# 30/70/0 57/36/7 0.0002
Atopic dermatitis, % 33 26  
Medications, %#    
   Omalizumab 28 0 <0.0001
   ICS-H 36 4 <0.0001
   ICS-M 52 18 0.0002
   ICS-L 10 62 <0.0001
   LABA 84 40 <0.0001
   LTRA 77 64  
Immunotherapy, % 4 5  
Pulmonary function*    
   FVC 88 ± 15 98 ± 11 <0.0001
   FEV-1 78 ± 16 94 ± 11 <0.0001
   FEF-25-75 64 ± 23 88 ± 23 <0.0001
   FEV-1/FVC 85 ± 12 93 ± 8 <0.0001
IgE, IU/ml* 469 ×/÷ 3.51 140 ×/÷ 5.01 0.0001
Sensitivites, %#    
   Alternaria 100 100  
   Cladosporium 46 35  
   Helminthosporium 32 28  
   Aspergillus 43 28  
   Der p and/or Der f 52 37  
   Cat 46 28  
   CR 28 22  
   Trees 78 57 0.01
   Grasses 56 54  
   Weeds 68 48 0.04
  1. Abbreviations: ICS-H, inhaled corticosteroid-high dose; ICS-M, -medium dose; ICS-L, -low dose; LABA, long-acting beta agonist; LTRA, leukotriene antagonist; IT, immunotherapy; FVC, forced vital capacity; FEV-1, forced expiratory volume 1 second; FEF, forced expiratory flow; CR, cockroach.
  2. Pulmonary Function data expressed presented as Mean ± SD; IgE data expressed as Geometric Mean×/÷SD; Sensitivities data expressed as percentage of patients.
  3. P value using Mann-Whitney U test* and Fisher's exact test#.