Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma

Table 1 Demographics of children with ***Alternaria-sensitive moderate-severe asthma compared to Alternaria*-sensitive mild asthma**.

Study	Moderate-Severe (60)	Mild (49)	P
Age, years	11 ± 4	10 ± 3
Sex, % male/female	62/38	64/36
White/Black/Hispanic, %^#	30/70/0	57/36/7	0.0002
Atopic dermatitis, %	33	26
Medications, %^#
Omalizumab	28	0	<0.0001
ICS-H	36	4	<0.0001
ICS-M	52	18	0.0002
ICS-L	10	62	<0.0001
LABA	84	40	<0.0001
LTRA	77	64
Immunotherapy, %	4	5
Pulmonary function*
FVC	88 ± 15	98 ± 11	<0.0001
FEV-1	78 ± 16	94 ± 11	<0.0001
FEF-25-75	64 ± 23	88 ± 23	<0.0001
FEV-1/FVC	85 ± 12	93 ± 8	<0.0001
IgE, IU/ml*	469 ×/÷ 3.51	140 ×/÷ 5.01	0.0001
Sensitivites, %^#
Alternaria	100	100
Cladosporium	46	35
Helminthosporium	32	28
Aspergillus	43	28
Der p and/or Der f	52	37
Cat	46	28
CR	28	22
Trees	78	57	0.01
Grasses	56	54
Weeds	68	48	0.04

Abbreviations: ICS-H, inhaled corticosteroid-high dose; ICS-M, -medium dose; ICS-L, -low dose; LABA, long-acting beta agonist; LTRA, leukotriene antagonist; IT, immunotherapy; FVC, forced vital capacity; FEV-1, forced expiratory volume 1 second; FEF, forced expiratory flow; CR, cockroach.
Pulmonary Function data expressed presented as Mean ± SD; IgE data expressed as Geometric Mean×/÷SD; Sensitivities data expressed as percentage of patients.
P value using Mann-Whitney U test* and Fisher's exact test^#.

ISSN: 1476-7961